YANAGAWA Toru

2020 - 2022 抗酸化ストレス応答転写因子Nrf2は肥満者におけるサルコペニアの形成を抑止する

2019 - 2022 Analysis of p62 nuclear - cytoplasm shuttling in the carcinogenesis of oral cancer

2018 - 2021 Intestinal dysbiosis increases the risk of hepatocellular carcinoma - the study for protective mechanism against carcinoma using new animal models

2018 - 2021 The characteristic changes of Kupffer cells and hepatic stellate cells after menopause increase the risk of NASH and liver cancer.

2018 - 2021 Periodontal disease increases a risk of hepatocarcinogenesis – Investigation of in vivo defense mechanism in a novel NASH model

2018 - 2021 Intestinal dysbiosis increases the risk of hepatocellular carcinoma - the study for protective mechanism against carcinoma using new animal models

2018 - 2021 The characteristic changes of Kupffer cells and hepatic stellate cells after menopause increase the risk of NASH and liver cancer.

2018 - 2021 Periodontal disease increases a risk of hepatocarcinogenesis – Investigation of in vivo defense mechanism in a novel NASH model

2017 - 2020 Roles of intestinal bacteria and oxidative stress responsive transcription factor Nrf2 in NASH pathogenesis

2017 - 2020 Exercise practice improves Kupffer cell function and reduces a risk of steatohepatitis and hepatic carcinogenesis.

2017 - 2020 Roles of intestinal bacteria and oxidative stress responsive transcription factor Nrf2 in NASH pathogenesis

2016 - 2019 Role of Pin1 in the development of pulmonary hypertension and therapeutic application

2016 - 2019 Exercise improves obesity-related liver disease through a reduction of tissue damaging factor, TWEAK by the activation Nrf2.

2015 - 2018 Functional characterization of oral cancer related microRNA and identification of novel therapeutics

2015 - 2018 Pathophysiological mechanism for the high incidence of overeating-induced obesity, NASH and hepatic carcinogenesis in post-menoposal women

2015 - 2018 Analysis of carcinogenesis in hepatocellular carcinoma using Nrf2-p62 double knock out mouse

2015 - 2017 Analysis and establishment of glossodynia model mouse from the view of the pain memory malformation hypothesis in hippocampal area

2015 - 2017 The role of Nrf2 in development and carcinogenesis of NASH using gene rescue mice

2015 - 2017 Increased risk for sarcopenic obesity in post-menoposal women due to estrogen deficiency and an inhibitory effect of Nrf2 activation on sarcopenic obesity

2014 - 2017 The regulatory role of Nrf2 in pathogenesis and carcinogenesis of NASH using gene rescued mice

2014 - 2017 Nrf2 regulates innate immunity activated by periodontal disease bacteria and prevents onset and progression of obesity-related liver diseases.

2014 - 2017 Elucidation of role of tissue or cellular Nrf2 in regulating NASH onset and progression using genetically modified mice.

2014 - 2016 Prevention of muscle atrophy in aged subjects by transcription factor Nrf2 through the modulation of anti-oxidative stress and autophagy systems.

2013 - 2016 Nrf2 activation inhibits steatohepatitis and liver cancer in overeating-induced obese mice.

2013 - 2016 Development of overeating-induced obese mouse assuming human life style-related diseases and investigation of pathophysiological factors associated with NASH

2013 - 2015 Investigation of novel antiangiogenic therapy against oral cancer targeting synaptic adhesion molecules

2013 - 2015 加速度訓練による高齢肥満者の身体機能および代謝病態の改善, 脂肪性肝疾患の進展予防

2012 - 2015 Analysis of wound healing mechanism in novel metabolic syndrome model mice

2012 - 2014 Iprovement of metabolic and exercise function of skeletal muscles through activation of transcription factor, and prevention of obesity-related liver disease

2012 - 2014 Exercise inhibits progression of obesity-related fatty liver disease through the regulation of activated innate immunity

2011 - 2014 Role of Keap1-Nrf2 system in skin wound healing process

2011 - 2014 Development of novel bio-therapy using hybrid peptide against intrahepatic cholangiocarcinoma

2011 - 2014 Improvement of metabolic and exercise function of skeletal muscles through activation of transcription factor, and prevention of obesity-related liver disease

2011 - 2013 Molecular function of Trim16 in wound healing

2011 - 2012 Analysis of cleft palate signal by using CASK knockout mouse

2010 - 2012 Activation of transcription factor by functional food constituents inhibits the onset and progression of obesity-related liver diseases through attenuating the enhanced innate immunity levels.

2009 - 2011 Analysis of autophagy related protein p62 in carcinogenesis of oral cancer

2009 - 2010 A170欠損マウスを用いた難治性顎骨骨髄炎の修復過程における中枢性骨制御の解析

2009 - 2010 麻酔・周術期の胆汁うっ滞性肝障害-漢方薬の転写因子賦活化による新しい肝保護効果

2008 - 2008 生活習慣病モデルマウスを用いた薬剤効果スクリーニング法の開発

2008 - 2008 A170ノックアウト脂肪肝マウスにおけるアカルボースの脂肪肝改善効果に関する研究

2006 - 2008 Analysis of oral diseases using oxidative stress inducible protein conditional knockout mouse

2006 - 2007 漢方製剤生薬成分の胆汁うっ滞に対する胆汁分泌促進と肝保護の新しい効果と分子機構

2004 - 2006 The analysis of bone related diseases in cranio and oro-maxillofacial region by using A170 gene knockout mouse

2003 - 2005 New evaluation system of cell damage caused by environmental chemicals that effect lifestyle diseases

2003 - 2004 スタチンの骨修復促進薬としての可能性の検討

2003 - 2004 Identification of transcription enhancing fator for PTH receptor and analysis it's mechanism at jaw bone resorption site by oral cancer

2002 - 2004 Analysis of lymph node metastasis of oral cancer by using peroxiredoxin I knockout mouse

2001 - 2003 Development of oral tumor markers by using oxidative stress inducible proteins

2000 - 2002 Analysis of the stress response in oral lesions by using Nrf2 gene knockout mouse

1999 - 2001 Analysis of stress defense mechanism against oral cancer by using A170 gene knockout mouse

Development of Clinical Marker For Oral Cancer

Analysis of oral diseases by using gene knockout mouse

Study on Oxdative stress protein