Research keywords (3):
Neural organoids
, Neuronal development
, RNA
Research theme for competitive and other funds (9):
2020 - 2024 機能する培養ヒト神経回路組織の構築
2020 - 2023 柔軟な神経らしさを作り出すパラメトリック翻訳制御の解明
2018 - 2020 In vitro model tissue of interregional cortical connections
2017 - 2019 神経の発生と疾患における新生鎖の生成機構と機能
2016 - 2019 Electrical TFT platform for fundamental understanding of neuromuscular communication in the aim of neuroprosthesis.
2015 - 2017 神経発生を司るmTORシグナル伝達経路依存的新生鎖合成制御機構の解析
2015 - 2017 Development of genetically encoded protein synthesis activity reporter
2014 - 2015 神経におけるタンパク質合成制御と自閉症の発症機構の解析
2004 - 2006 リボヌクレオーム解析によるRNA修飾酵素遺伝子の網羅的探索
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Papers (78):
Catarina Martins-Costa, Andrea Wiegers, Vincent A Pham, Jaydeep Sidhaye, Balint Doleschall, Maria Novatchkova, Thomas Lendl, Marielle Piber, Angela Peer, Paul Möseneder, et al. ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum. Cell stem cell. 2024
Tatsuya Osaki, Tomoya Duenki, Siu Yu A. Chow, Yasuhiro Ikegami, Romain Beaubois, Timothée Levi, Nao Nakagawa-Tamagawa, Yoji Hirano, Yoshiho Ikeuchi. Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons. Nature Communications. 2024. 15. 2945
Antonios Apostolopoulos, Naohiro Kawamoto, Siu Yu A Chow, Hitomi Tsuiji, Yoshiho Ikeuchi, Yuichi Shichino, Shintaro Iwasaki. dCas13-mediated translational repression for accurate gene silencing in mammalian cells. Nature communications. 2024. 15. 1. 2205-2205
Yasuhiro Ikegami, Tomoya Duenki, Ikuma Arakaki, Ryo Sakai, Tatsuya Osaki, Satoshi Ashihara, Tsuyoshi Furushima, Yoshiho Ikeuchi. A simple and inexpensive laser dissection of fasciculated axons from motor nerve organoids. Frontiers in Bioengineering and Biotechnology. 2024. 12
Sabin A Nettles, Yoshiho Ikeuchi, Katheryn B Lefton, Ladan Abbasi, Alyssa Erickson, Chibueze Agwu, Thomas Papouin, Azad Bonni, Harrison W Gabel. MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes. Cell reports. 2023. 42. 12. 113538-113538