Rchr
J-GLOBAL ID：200901097280753264
Update date: Nov. 04, 2024
Kira Junichi
吉良 潤一 | Kira Junichi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.med.kyushu-u.ac.jp/neuro/
Research field (1)：
Neurology
Research keywords (2)：
神経病態免疫学
, clinical neuroimmunology
Research theme for competitive and other funds (58)：
- 2023 - 2026 ヘミチャネル阻害薬を用いたαシヌクレイン伝播阻止による多系統萎縮症の治療法開発
- 2023 - 2025 Elucidation of glia inflammation mechanisms common to degeneration and demyelination by novel pathogenic microglia
- 2022 - 2025 単一細胞RNA解析による多系統萎縮症増悪性ミクログリア亜群の同定と同細胞標的療法
- 2022 - 2025 毒性ターンAβ42含有エキソソームによるアルツハイマー病早期診断と病態伝搬の解明
- 2022 - 2025 Mechanisms and therapy of autoimmune nodopathy type central and peripheral demyelination by newly discovered anti-nodal antibodies
- 2022 - 2025 中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立
- 2021 - 2024 グリアコネキシン低分子量イソフォーム発現エキソソームによる脱髄炎の悪化と治療開発
- 2020 - 2023 A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression
- 2020 - 2023 活性化グリア細胞制御による進行性多発性硬化症および多系統萎縮症の画期的治療法開発
- 2020 - 2023 Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channel
- 2019 - 2022 Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system
- 2019 - 2022 Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
- 2018 - 2021 Parent-of-origin effect in multiple sclerosis susceptibility
- 2016 - 2020 A Study of improving treatment efficiency of acute stroke care by revamping acute phase protocol
- 2017 - 2019 Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.
- 2016 - 2019 Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.
- 2015 - 2018 Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange
- 2015 - 2018 Retro-element insertion polymorphism in pathogenic Th17 cells specific for multiple sclerosis and its action
- 2013 - 2018 Glial assembly:a new regulatory machinery of brain function and disorders
- 2015 - 2017 Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.
- 2013 - 2017 Elucidasion of functional contribution of glial dysturbances in pathomechanisms of demyelinating diseases and schizophrenia and development of new therapeutic options
- 2013 - 2016 Investigation of the role of TRPV4 in acute ischemic stroke
- 2013 - 2015 To generate and analyze new Parkinson's disease mice model with increased oxidative stress
- 2013 - 2015 connexin cytopathy in the pathogenesis of demyelinating disorders
- 2013 - 2014 Developing a cell transplantation therapy for chronic multiple sclerosis by using Schwann cells induced from mesenchymal stem cells
- 2011 - 2012 Connexin astrocytopathy in the pathogenesis of demyelination in concentric sclerosis and multiple sclerosis
- 2010 - 2012 The influence of genetic polymorphism on preoperative platelet function testing in patients undergoing Carotid Artery Stenting
- 2010 - 2012 Development of molecular targeted therapy of multiple sclerosis on the basis of membrane protein microarray analysis and gene interactions
- 2008 - 2009 軸索型ギラン・バレー症候群先行感染菌由来蛋白の軸索膜ポア形成による傷害とその治療
- 2006 - 2008 Role of IL-17 producing T cells in opticospinal multiple sclerosis
- 2006 - 2007 筋萎縮性側索硬化症に対するG-CSF療法の開発
- 2002 - 2007 多発性硬化症の神経免疫学的研究
- 2002 - 2007 Neuroimmunological study on multiple sclerosis
- 2005 - 2006 HLA class II polymorphism and worldwide susceptibility to optico-spinal multiple sclerosis.
- 2002 - 2004 Development and pharmacological analysis of therapeutic drugs for conformation diseases and prion diseases
- 2002 - 2003 Analysis of the effect with the, expanded CTG repeat for cell toxicity, especially tauopathy in the central nervous system in patietnt of myotonic dystrophy type 1 (DM 1)
- 2002 - 2003 Development of an animal model of opticospinal form of multiple sclerosis using the HLA-DP5 transgenic mice.
- 2002 - 2002 アトピー素因を伴う脊髄炎・ミエロパチーにおける疾患感受性遺伝子の検索
- 2001 - 2002 STUDY OF ALLERGIC REACTION IN PATHOGENESIS OF MYASTHENIA GRAVIS
- 2000 - 2002 Detection of prion infectivity of vibrinogen in human blood
- 2000 - 2001 Identification of a specific autoantigen in opticospinal form of multiple sclerosis based on the HLA-DPB1 binding motif
- 2000 - 2001 MOLECULAR AND PATHOLOGICAL ANALYSIS OF SPINAL CORD EOSINOPHILIC LESIONS IN ATOPIC MYELITIS
- 1999 - 2001 Analysis of TCR/HLA/ peptide interaction and investigation of etiology of autoimmune diseases
- 1999 - 2001 THE DIVESITY IN ANTIGEN RECOGNITION AND RESPONSE OF ANTIGEN-SPECIFIC HUMAN CD4^+ T-CELL CLONES
- 2000 - 2000 アトピー性疾患に伴う脊髄前角運動ニューロン傷害の発生機序に関する分子免疫学的研究
- 1999 - 2000 アジア型多発性硬化症特異的なHLA-DPB1*0501拘束性T細胞株の樹立と対応する脳自己抗原の同定
- 1998 - 2000 アストロサイト由来の自己反応性T細胞抑制因子の解明と遺伝子クローニング
- 1999 - 1999 HIV-1のヒト正常リンパ球ーの潜伏感染機構の解明
- 1999 - 1999 アトピー性皮膚炎自然発症マウスを用いたアトピー性脊髄炎動物モデルの作製
- 1998 - 1999 Establishment of a polyreactive T cell clone from Asian type multiple sclerosis patients and identification of the responsible antigens
- 1998 - 1999 Induction of chronic inflammatory myelopathy in rats infected with recombinant HTLV-I
- 1998 - 1998 日本人の自己免疫疾患に特有のHLAクラスII・自己抗原ペプチド複合体の解析
- 1998 - 1998 ダニ抗原特異的なアトピーを特徴とする脊髄炎におけるTh2タイプT細胞応答の解析
- 1996 - 1997 Analysis of T cell epitope in Asian type multiple sclerosis
- 1994 - 1994 HTLV-1に対するペプチドワクチンの開発
- 1993 - 1994 The presence of mutant HTLV-I in the central nervous system
- 1991 - 1992 神経親和性ヒトレトロウイルスによる神経障害機構の分子遺伝学的及び細胞生物学的解析
- 1988 - 1990 Study of Immunomechanisms in HTLV-I-Associated Myelopathy(HAM)
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Papers (1,191)：
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Mitsuru Watanabe, Noriko Isobe, Masaaki Niino, Ichiro Nakashima, Takuya Matsushita, Yasunari Sakai, Jin Nakahara, Izumi Kawachi, Hirofumi Ochi, Yuji Nakatsuji, et al. Prevalence of, and Disability Due to, Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder in Japan by the Fifth Nationwide Survey. Neurology. 2024. 103. 10
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Eizo Tanaka, Ryo Yamasaki, Ban-Yu Saitoh, Amina Abdelhadi, Satoshi Nagata, Sato Yoshidomi, Yuka Inoue, Koichiro Matsumoto, Jun-Ichi Kira, Noriko Isobe. Postnatal Allergic Inhalation Induces Glial Inflammation in the Olfactory Bulb and Leads to Autism-Like Traits in Mice. International journal of molecular sciences. 2024. 25. 19
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Akira Yokote, Ken-Ichiro Yamashita, Ayako Sakoda, Yasutaka Iwanaga, Yuri Nakamura, Keiko Haro, Yasuhiro Kanamoto, Naoko Matsubara, Jun-Ichi Kira. Zoster Sine Herpete Affecting Multiple Lower Cranial Nerves Presenting Severe Dysphagia in a Patient with Parkinson's Disease. Internal medicine (Tokyo, Japan). 2024
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Hiroo Yamaguchi, Yuji Nishimura, Dai Matsuse, Hiroaki Sekiya, Katsuhisa Masaki, Tatsunori Tanaka, Toru Saiga, Masaya Harada, Yuu-Ichi Kira, Dennis W Dickson, et al. A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates. Brain, behavior, and immunity. 2024. 121. 122-141
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Ezgi Ozdemir Takase, Ryo Yamasaki, Satoshi Nagata, Mitsuru Watanabe, Katsuhisa Masaki, Hiroo Yamaguchi, Jun-Ichi Kira, Hideyuki Takeuchi, Noriko Isobe. Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model. Scientific reports. 2024. 14. 1. 10877-10877
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MISC (962)：
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磯部紀子, 渡邉充, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 河内泉, 越智博文, et al. 神経免疫疾患の診断・重症度分類・ガイドラインの妥当性検証・改定と全国調査による患者QOLの改善の検証 第5回全国調査からみた多発性硬化症の重症度に寄与する因子の検討. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 令和3年度 総括・分担研究報告書(Web). 2022
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新野正明, 福元尚子, 奥野龍禎, 三條伸夫, 深浦彦彰, 森雅裕, 大橋高志, 竹内英之, 清水優子, 藤盛寿一, et al. 日本人多発性硬化症患者における認知機能とQOL,疲労,抑うつとの相関. 日本神経学会学術大会プログラム・抄録集. 2022. 63rd
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吉良潤一, 吉良潤一, 磯部紀子, 渡邉充, 松下拓也, 福元尚子, 林史恵, 新野正明, 宮崎雄生, 中島一郎, et al. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 第5回多発性硬化症・視神経脊髄炎全国臨床疫学調査結果 第2報. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 令和2年度 総括・分担研究報告書(Web). 2021
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岩永育貴, 齋藤万有, 迫田礼子, 柳原由記, 中村優理, 山下謙一郎, 飛松省三, 緒方英紀, 吉良潤一. 抗Contactin-1抗体陽性CIDPの一例. 臨床神経学(Web). 2021. 61. 11
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Jun-ichi Kira, Noriko Isobe, Masaaki Niino, Takuya Matsushita, Yuri Nakamura, Ichiro Nakashima, Mitsuru Watanabe, Yasunari Sakai, Ayako Sakoda, Jin Nakahara, et al. Continued Increase of Multiple Sclerosis and Neuromyelitis Optica in Japan: Updates from the 5th Nationwide Survey. ANNALS OF NEUROLOGY. 2020. 88. S199-S200
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Books (25)：
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神経内科研修ノート : neurology
診断と治療社 2015 ISBN:9784787820792
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MS FRONTIER 3ー2-多発性硬化症の先端情報誌 座談会多発性硬化症の環境因子をめぐって
メディカルレビュー社 2014 ISBN:4779213878
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今日の神経疾患治療指針 第2版 (今日の治療指針シリーズ)
医学書院 2013 ISBN:4260016210
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今日の神経疾患治療指針
医学書院 2013 ISBN:9784260016216
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最新アプローチ 多発性硬化症と視神経脊髄炎 (アクチュアル 脳・神経疾患の臨床)
中山書店 2012 ISBN:4521734413
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