Rchr
J-GLOBAL ID:200901097440247794
Update date: Feb. 14, 2024
Makino Keisuke
マキノ ケイスケ | Makino Keisuke
Affiliation and department:
Job title:
Executive Director,Director
Research field (1):
Molecular biochemistry
Research keywords (2):
生物化学
, Biochemistry
Research theme for competitive and other funds (8):
- 2002 - 5員環糖資化酵素遺伝子組み換え酵母作成とバイオインフォーマティクスおよびタンパク質工学を基盤とした酵素補酵素特異性の変換・調整
- 2002 - Development of pentose-fermenting Saccharomyces cerevisiae by introducing the genes of other organisms and by manipulating their coenzyme specificity based on bioinformatics data and protein-engineering technology
- 1998 - 遺伝子診断システム開発
- 1998 - Development of gene analysis systems
- 1995 - 対虚血再灌流傷害活性および抗癌作用を持ったプテリン誘導体の開発と医薬としての応用
- 1995 - 一酸化窒素と遺伝子の直接反応とその生物学的意義
- 1995 - Development of puterin derivatives which have anti-reperfusion-ischemia-injury and anti-cancer activities and their application
- 1995 - Direct Reaction of Nitric Oxide with Gene and Its Biological Implication
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MISC (326):
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Protein-engineering of dehydrogenase; complete reversal of coenzyme specificity and increased thermostability by introduction of new-structural zinc. J. Biol. Chem. 2005. in Press
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K Kanaori, S Sakamoto, H Yoshida, P Guga, W Stec, K Tajima, K Makino. Effect of phosphorothioate chirality on i-motif structure and stability. BIOCHEMISTRY. 2004. 43. 19. 5672-5679
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K Sugimoto, M Nishida, M Otsuka, K Makino, K Ohkubo, Y Mori, T Morii. Novel real-time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate production in intact cells. CHEMISTRY & BIOLOGY. 2004. 11. 4. 475-485
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ZG Cui, T Kondo, R Ogawa, LB Feril, QL Zhao, S Wada, T Arai, K Makino. Enhancement of radiation-induced apoptosis by 6-formylpterin. FREE RADICAL RESEARCH. 2004. 38. 4. 363-373
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T Arai, H Yamada, T Namba, H Mori, H Ishii, K Yamashita, M Sasada, K Makino, K Fukuda. Effects of intracellular reactive oxygen species generated by 6-formylpterin on T cell functions. BIOCHEMICAL PHARMACOLOGY. 2004. 67. 6. 1185-1193
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Patents (15):
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変異型キシリトールデヒドロゲナーゼ酵素、これを生産する微生物、該酵素または微生物を用いたキシリトールをキシロースに変換する方法
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プテリン誘導体を含有する放射線増感剤
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プテリン誘導体を含有する免疫抑制剤
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プテリン誘導体含有白血球殺菌活性増強剤
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プテリン誘導体含有アポトーシス抑制剤
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Books (26):
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京大人気講義シリーズ エネルギー・環境・社会 現代技術社会論「第6章 環境ホルモンの科学」
丸善 2004
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Sequence-specific DNA binding by short peptides.
Advances in DNA Sequence -specific Agents, Vol 4, ed G. B. Jones, Elsevier Science B.V. 2002
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超臨界クロマトグラフィー
(牧野圭祐編、訳書、R.M.Smith著、廣川書店) 2001
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バイオマスからの環境ホルモン
(坂志朗編「バイオマス・エネルギー・環境」,アイピーシー) 2001
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Redox behavior of 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO) as studies by electrochemical-ESR measurement (Ed. C. Z. Rudowich, "Modern Applications of EPR/ESR")
Springer 1998
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Education (4):
- - 1970 Kyoto University
- - 1970 Kyoto University Graduate School, Division of Engineering
- - 1968 Kyoto University Faculty of Engineering
- - 1968 Kyoto University Faculty of Engineering Department of Fuclchemistry
Professional career (2):
- Doctor of Science (Kyoto University)
- Master of Engineering (Kyoto University)
Work history (23):
- 1996 - 2001 Kyoto University Institute of Advanced Energy
- 1996 - 2001 ┣DBProfessor(/)-┫DB,
- 2001 - - 京都大学国際融合創造センター教授
- 2001 - - ┣DBProfessor(/)-┫DB,
- 1988 - 1996 Kyoto Institute of Technology
- 1988 - 1996 ┣DBProfessor(/)-┫DB,
- 1982 - 1988 Kyoto Institute of Technology
- 1982 - 1988 ┣DBAssociate Professor(/)-┫DB,
- 1980 - 1982 米国国立衛生研究所外国人研究員
- 1980 - 1982 ┣DBVisiting Fellow(/)-┫DB,
- 1978 - 1980 Kyoto University Faculty of Science
- 1978 - 1980 ┣DBResearch Fellow(/)-┫DB,
- 1970 - 1978 鐘紡(株)研究員
- 1970 - 1978 ┣DBResearcher(/)-┫DB, Kanebo Ltd. , Osaka.
- Department of Chemistry, Faculty of Science,
- National Institutes of Health, USA.
- National Cancer Institute,
- Kyoto Institute of Technology
- Department of Polymer Science and Engineering,
- Kyoto University,
- Institute of Advanced Energy,
- Kyoto University
- International Innovation Center,
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Committee career (2):
- 2002 - 現在 電子スピンサイエンス学会 理事、評議員
- 1994 - 現在 日本生化学会 評議員
Awards (1):
- 2004 - 日本神経病理学会 平成16年度学会賞
Association Membership(s) (8):
ニューヨークアカデミーオブサイエンス
, 電子スピンサイエンス学会
, 高分子学会
, アメリカ化学会
, 日本生化学会
, 日本化学会
, New York Academy of Sciences
, American Chemical Society
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