Tano Keizo

タノケイゾウ | Tano Keizo

Affiliation and department：

Research field (1)： Cell biology

Research keywords (3)：放射線影響 , 環境変異原 , DNA修復

Research theme for competitive and other funds (21)：

2024 - 2027 Biguanide系薬剤Metforminの腫瘍内環境特性による細胞致死と抗腫瘍免疫誘導の解析
2019 - 2022 Interrelationship analysis of the characteristics of quiescent tumor cells with tumor heterogeneity and cancer stem cell nature, referring to application to cancer therapy
2018 - 2021 Analyses of selective cytotoxicity of the anti-diabetic biguanide drug, Metformin, in solid tumor specific microenvironment
2015 - 2019 Analysis of neoplastic cell-specific fatal effects with reactive oxygen species abnormality derived from compound from plant species, piperlongumine
2015 - 2018 An attempt to achieve both controlling local tumors and repressing distant metastases through exploiting analytical findings concerning characteristics of intratumor microenvironment

2014 - 2017 An attempt to improve the possibilities of controlling local tumors through taking it into account to increase the sensitivity of oxic quiescent tumor cells

2012 - 2016 Biological impact Mechanism maintenance and assessment of biological impact of intracellular reactive oxygen species produced by normal physiological reaction

2011 - 2014 Exploration and exploit of intratumor microenvironment for both controlling local tumors and reducing distant metastatic potential

2008 - 2010 Characterization and biological assessment of DNA-Protein crosslink repair in vertebrate cells

2008 - 2010 Analyzing and exploiting the characteristics of intratumor quiescent cells in search of the potential as a cancer stem cell

2006 - 2007 Analysis of the effect of reduced dose rate and fractionated irradiation, including the effectoniniraturnor quiescent cells

2005 - 2006 Bio-imaging of DNA repair machinery

2003 - 2004 Analysis of error-prone polymerases in vertebrate cells

2003 - 2003 LET増加に伴うRBEの上昇はDNA二重鎖切断のエラー修復で説明できるか

2002 - 2003 Role of DNA double-strand break repair on low dose rate effects

2001 - 2001 低線量放射線と酸化的代謝による傷害とは同じか違うか

1999 - 2001 DNA repair research using DNA double-strand break repair-gene knockout mutants

1997 - 1998 Mutational Specificity of Photosynthetic Organism, Cyanobacterium Synechococcus at Molecular Level

1996 - 1997 Establishment and Characterization of Hypocatalasemic Mouse Cell

1996 - 1997 Trial manufacture of the automatic and remote-controlled apparatus for the mass production of ^<195>mpt radiolabeled compounds

1995 - 1995 環境要因により生じる多様なDNA塩基損傷を除去する酵素の研究

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Papers (83)：

Toshiaki Nakano, Takahito Moriwaki, Masataka Tsuda, Misa Miyakawa, Yuto Hanaichi, Hiroyuki Sasanuma, Kouji Hirota, Masanobu Kawanishi, Hiroshi Ide, Keizo Tano, et al. SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2′-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line. Chemical Research in Toxicology. 2022. 33. 11. 2059-2067
Takahito Moriwaki, Akari Yoshimura, Yuki Tamari, Hiroyuki Sasanuma, Shunichi Takeda, Masayuki Seki, Keizo Tano. PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40. Genes and environment. 2021. 43. 1. 35
Shin-Ichiro Masunaga, Yu Sanada, Keizo Tano, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Koji Ono. An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness. Journal of radiation research. 2020. 61. 6. 876-885
Toshiaki Nakano, Mahmoud I. Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Kouji Hirota, Minoru Takata, Shin-ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, et al. Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells. PLOS ONE. 2020. 15. 6. e0234859-e0234859
Shin-Ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Yu Sanada, Keizo Tano, Akira Maruhashi, Koji Ono. Usefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential. International journal of radiation biology. 2019. 95. 12. 1708-1717

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MISC (184)：

中野敏彰, 笹沼博之, 津田雅貴, 廣田耕志, 赤松憲, 川西優喜, 武田俊一, 井出博, 田野恵三. DNAタンパク質クロスリンク損傷修復におけるSPRTNの関与. 第43回日本分子生物学会年会. 2020
中野敏彰, 笹沼博之, 津田雅貴, 廣田耕志, 赤松憲, 川西優喜, 武田俊一, 井出博, 田野恵三. SPRTNはazadCによって導入されたDPCの修復機構に関与している. 日本環境変異原学会第49回大会. 2020
真田悠生, 高田卓志, 田中浩基, 櫻井良憲, 田野恵三, 増永慎一郎. Hif-1α遺伝子欠損がBNCTの殺細胞効果を増強する. KURNS-EKR (Web). 2020. 6
Toshiaki Nakano, Mahmoud Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Shin-ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, Keizo Tano. How does TDP1 exert in DNA-protein cross-links repair mechanism?. ACEM/JEMS 2019. 2019
藤池春奈, Mahmoud Shoulkamy, Amir Salem, 津田雅貴, 笹沼博之, 増永慎一郎, 武田俊一, 井出博, 田野恵三. 脊椎動物細胞におけるDNA-タンパク質クロスリンク損傷修復へのTDP1, TDP2 遺伝子産物の関与. 第41 回日本分子生物学会年会. 2018

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Books (1)：

DNA Repair mechanisms : proceedings of the Alfred Benzon Symposium 35 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, 9-13 August 1992
1993 ISBN:8716110765

Lectures and oral presentations (2)：

Optimization of intracellular reactive oxygen species levels by antioxidant peoteins in vertebrate cells
(The Sugahara Memorial International Symposium 2012 2012)
酸化ストレス下におけるFlap-endonuclease1のlong-patch塩基除去修復及びDNA複製フォーク伸長維持への働き
(日本放射線影響学会第49回大会, 酸化的塩基損傷と塩基除去修復ワークショップ 2006)

Education (3)：

1981 - 1985 Nara Medical University
1978 - 1980 Osaka City University
1974 - 1978 Nara University of Education

Professional career (1)：

Doctor of Medical Science (Nara Medical University)

Work history (9)：

2022/04 - 現在 Osaka Metropolitan University Graduate School of Science Department of Biological Chemistry
2020/04 - 2022/03 Osaka Prefecture University Graduate School of Science Department of Biological Science
2018/04 - 2020/03 京都大学複合原子力科学研究所准教授
2007/04 - 2018/03 京都大学原子炉実験所准教授
1996/08 - 2007/04 京都大学原子炉実験所助教授

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Association Membership(s) (2)：

The Japanese Environmental Mutagen Society , The Molecular Biology Society of Japan

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