Rchr
J-GLOBAL ID:200901098950282949
Update date: Sep. 21, 2024
Takayuki Shibata
シバタ タカユキ | Takayuki Shibata
Affiliation and department:
Job title:
Associate Professor
Homepage URL (2):
http://www.health.gunma-u.ac.jp/unit/4007.html
,
http://www.ph.nagasaki-u.ac.jp/lab/function/index-j.html
Research field (2):
Other
, Pharmaceuticals - chemistry and drug development
Research keywords (7):
臨床検査学
, 核酸化学
, 有機化学
, 分析化学
, Nucleic Acids Chemistry
, Organic Chemistry
, Analytical Chemistry
Research theme for competitive and other funds (13):
- 2020 - 2023 カテコール蛍光誘導体化反応を利用したNADP+の直接測定法の開発
- 2017 - 2018 非放射化学的なジヒドロピリミジンデヒドロゲナーゼ活性の直接測定法
- 2014 - 2017 Development of the anti-AIDS drug using aptamer-siRNA
- 2015 - 2017 慢性閉塞性肺疾患の早期検査法の開発
- 2011 - 2014 抗癌剤の副作用リスクをスクリーニング検査できる新規蛍光誘導体化法の開発
- 2012 - 2013 5-FU代謝異常症のスクリーニング検査法の確立
- 2011 - 2013 Development of the discrimination method for mutation and drug resistance of an AIDS virus
- 2011 - 2012 DPD欠損症のスクリーニング検査を指向した尿中ウラシル定量法の開発
- 2010 - 2011 リン酸化ペプチドの一次配列決定を可能にする次世代エドマン分解法
- 2007 - 2010 Development of a novel detection method for abnormal prion protein
- 2010 - Highthrouput diagnosis of dihydropyrimidine dehydrogenase deficiency
- 2010 - A new generation of Edman degradation that enables amino acid sequencing of phosphorylated peptides.
- 2008 - 2009 人工修飾核酸によるRNA干渉法を応用した新規抗HIV薬の創製
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Papers (50):
-
Yu Mikame, Yui Sakai, Ryo Tahara, Kinuka Doi, Tsuyoshi Yamamoto, Chikara Dohno, Takayuki Shibata, Asako Yamayoshi. Synthesis and Evaluation of Oligonucleotide-Containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools. Chemical and Pharmaceutical Bulletin. 2022. 70. 10. 726-730
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Takayuki Shibata, Ryosuke Shimamura, Yuji Yamamoto, Hiroki Sakurai, Junya Fujita, Asako Yamayoshi, Toshimitsu Nemoto, Tsutomu Kabashima. A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-Specific Fluorescence Derivatization Reaction. Chemical & pharmaceutical bulletin. 2021. 69. 8. 768-772
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Yamayoshi A, Higuchi M, Sakai Y, Kobori A, Yamamoto T, Shibata T, Murakami A. Selective cross-linking behavior of oligodeoxyribonucleotides containing 2'-<i>O</i>-[<i>N</i>-(4,5',8-trimethylpsoralen-4'-ylmethylcarbamoyl)]adenosine to mutant <i>H-ras</i> DNA. Nucleosides, nucleotides & nucleic acids. 2019. 1-12
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Shibata T, Yoshimura H, Yamayoshi A, Tsuda N, Dragusha S. Hydrazide Derivatives of Luminol for Chemiluminescence-labelling of Macromolecules. Chem. Pharm. Bull. 2019. 67. 8. 772-774
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Kabashima T, Tonooka K, TakadaM, Kai M, Shibata T. Simultaneous assay for protease activities of hepatitis C virus and human immunodeficiency virus based on fluorescence detection. Scientific Reports. 2019. 9. 1. 9150-9150
more...
Patents (10):
Lectures and oral presentations (24):
-
4-Trifluorobenzamidoxime as a specific fluorogenic reagent for cytosine
(2012)
-
Inhibition of HIV-1 Protease Expression in T cells Using CD4 aptamer-siRNA Chimeras
(第28回日本薬学会九州支部大会 2011)
-
3-メチルベンズアミドオキシムを用いた尿中ウラシル定量法およびジヒドロピリミジン脱水素酵素欠損症診断への応用
(日本分析化学会第60年会 2011)
-
ウラシル特異的な蛍光反応によるDPD欠損の簡易診断
(第26回 国際バイオEXPO 2011)
-
Inhibition of HIV-1 Protease Expression in T cells Using CD4 aptamer-siRNA Chimeras
(2011)
more...
Works (4):
-
抗癌剤の副作用リスクをスクリーニング検査できる新規蛍光誘導体化法の開発
2011 - 現在
-
ジヒドロピリミジンデヒドロゲナーゼ欠損症のハイスループット診断
2010 - 現在
-
DPD欠損症のスクリーニング検査を指向した尿中ウラシル定量法の開発
2011 - 2012
-
リン酸化ペプチドの一次配列決定を可能にする次世代エドマン分解法
2010 -
Education (4):
- - 2002 Kyushu University
- - 2002 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- - 1997 Kyushu University School of Pharmaceutical Sciences
- - 1997 Kyushu University Faculty of Pharmaceutical Science
Professional career (1):
Work history (8):
- 2018/05 - 現在 Gunma University Graduate School of Health Sciences Associate Professor
- 2007 - 2018 Nagasaki University Graduate School of Biomedical Sciences, Pharmaceutical Sciences Assistant Professor
- 2006 - 2007 Nagasaki University Graduate School of Biomedical Sciences
- 2006 - 2007 Research Associate,Pharmaceutical Sciences,Pharmaceutical Sciences,Graduate School of Biomedical Sciences,Nagasaki University
- 2007 - Nagasaki University Graduate School of Biomedical Sciences
- 2007 - Assistant Professor,Pharmaceutical Sciences,Pharmaceutical Sciences,Graduate School of Biomedical Sciences,Nagasaki University
- 2002 - 2006 シェフィールド大学 研究員
- 2002 - 2006 Researcher,The University of Sheffield
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Committee career (2):
- 2011 - 現在 日本分析化学会 幹事
- 2012/03 - 2013/02 日本分析化学会 会計幹事
Association Membership(s) (4):
日本分析化学会
, 日本薬学会
, The Japan Society for Analytical Chemistry
, The Pharmaceutical Society of Japan
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