Matsunaga Tamihide

マツナガタミヒデ | Matsunaga Tamihide

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www2.phar.nagoya-cu.ac.jp/research_course_/res_course20.html

Research field (5)： Cell biology , Pharmaceuticals - chemistry and drug development , Pharmacology , Pharmaceuticals - health and biochemistry , Clinical pharmacy

Research keywords (3)：分化 , 肝細胞 , ヒトiPS細胞

Research theme for competitive and other funds (40)：

2022 - 2026 生体内免疫応答と修復機構の統合的解析による尿路結石の病態解明と溶解療法への展開
2021 - 2026 疾患iPS細胞由来腎オルガノイドの樹立による新規腎結石モデルと結石溶解療法の開発
2022 - 2025 転写因子KLFファミリーの機能から紐解く腸管炎症制御と線維化メカニズム
2022 - 2025 灌流型小腸-肝臓2臓器連結デバイスを用いた胆汁鬱滞肝毒性評価系の展開
2022 - 2025 Study on proper use of oral anticoagulants combined with 5-fluorouracil

2022 - 2025 腸と肝臓の臓器間相互作用(腸肝軸)in vitroモデルの構築とその評価

2021 - 2025 生活習慣病の新規概念「毒性終末糖化産物(Toxic AGEs)原因説」の確立

2020 - 2023 ALS患者iPS細胞由来ミクログリアを用いた炎症反応模倣BBB評価系の構築

2020 - 2023 尿路結石マトリックス蛋白オステオポンチンを標的としたマクロファージ貪食機序の解明

2019 - 2023 Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms

2019 - 2022 Creation of pharmacokinetics and toxicity prediction model system using human iPS cell-derived small intestinal cells and tissues

2019 - 2022 Factors involved in the efficacy and safety of biopharmaceuticals

2017 - 2020 The construction of a blood-brain barrier model using novel human iPS cell-derived endothelial progenitor cells

2016 - 2020 Generation and accumulation of intracellular toxic advanced glycation end-products due to modern dietary habits and elucidation of relevant cytotoxic mechanisms

2016 - 2019 Biofabrication of functional 3D tissues

2016 - 2019 Study of the infusion reaction by rituximab

2016 - 2019 Monitoring of transplanted hepatocytes and analysis of immune rejection responses in the hepatocyte chimeric mouse system.

2016 - 2018 Construction of a model for intestinal toxicity test using human and monkey iPS cells and search for toxic biomarker

2014 - 2017 Differentiation of human iPS cells into hepatocytes and enterocytes: Development of first pass effect assessment model

2014 - 2017 Elucidating the mechanism of vascular dysfunction to achieve gender-specific medicine

2014 - 2016 Establishment of induced pluripotent stem cells from glycogen storage disease type Ib patient and making disease models

2013 - 2016 Development and clinical evaluation of hepatitis onset model of chimeric mice with iPS-derived human hepatocytes

2013 - 2016 Investigation of the infusion reaction development coursed by molecular target medicine prescription

2011 - 2014 Generation of Monkey/Mouse Chimera with Monkey Liver by Interspecific Blastocyst Injection of Monkey induced Pluripotent Stem Cells

2011 - 2013 Mechanism of vascular dysfunction with continuous hyperglicemia or postprandial hyperglycemia and development of treatment strategy

2010 - 2012 Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development study

2010 - 2012 Chemopreventive effects of vitamin K cycle using human iPS cells

2008 - 2010 ヒト胎児肝細胞におけるCYP3A分子種の発現変動要因の解明

2006 - 2007 妊娠と薬:胎児における薬物動態変動因子の解明

2005 - 2006 サル胚性幹細胞の肝細胞への分化と胎児薬物動態予測モデルの構築

2004 - 2005 Basic Study for Regenerative Medicine : Differentiate of Human Fetal Liver Cells and Application for Drug Pharmacokinetic Experiments

2003 - 2005 Basic Study for Regenerative Medicine : Differentiate of Embryonic Stem Cells to Hepatocytes and Expressions of Cytochrome P450 in the Differentiating Cells

1998 - 1999 Structures and Function of Novel Esterase and Amidohydrolase

1998 - 1999 Structure and Function of NAD/NADP Requirement Microsomal Alcohol Dehydrogensase

1995 - 1995 アルコールをケトン体へ酸化する新規P450のcDNAクローニングと反応機構解析

1994 - 1995 Analyzes of Structure and Function of Novel Carbonyl Metabolic Enzymes : MALDO and MALCO

1994 - 1995 新規アイソザイムP450MUT-2(MALDO)の役割とその反応機構解明

1991 - 1992 新規シトクロムP450アイソザイムMALDOの分子レベルにおける反応機構解析

1990 - 1990 異物アルデヒドからカルボン酸への酸化を触媒するP-450分子種の構造と発見調節

1989 - 1990 Nobel Mechanism in Xenobiotic Metabolism-Oxygenation of Aldehydes to Carboxylic Acids

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Papers (187)：

Tomoki Okada, Atsushi Okada, Hiromasa Aoki, Daichi Onozato, Taiki Kato, Hiroshi Takase, Shigeru Ohshima, Teruaki Sugino, Rei Unno, Kazumi Taguchi, et al. Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages. Urolithiasis. 2024. 52. 1
Yuki Imakura, Shinji Mima, Nao Yamazaki, Akira Inomata, Seiichi Mochizuki, Takahiro Iwao, Tamihide Matsunaga. Utility of human induced pluripotent stem cell-derived small intestinal epithelial cells for pharmacokinetic, toxicological, and immunological studies. Biochemical and Biophysical Research Communications. 2024. 692
Yuki Imakura, Shinji Mima, Nao Yamazaki, Akira Inomata, Seiichi Mochizuki, Takahiro Iwao, Tamihide Matsunaga. Utility of human induced pluripotent stem cell-derived small intestinal epithelial cells for pharmacokinetic, toxicological, and immunological studies. Biochemical and biophysical research communications. 2024. 692. 149356-149356
Masato Noda, Chigusa Kikuchi, Eisei Hori, Takahiro Iwao, Chie Nagami, Masayoshi Takeuchi, Tamihide Matsunaga. Effect of Anagliptin on Vascular Injury in the Femoral Artery of Type 2 Diabetic Rats. Biological & pharmaceutical bulletin. 2024. 47. 1. 204-212
Shota Mizuno, Yumi Jinnoh, Ayaka Arita, Shimeng Qiu, Tadahiro Hashita, Eisei Hori, Takahiro Iwao, Tamihide Matsunaga. New Maintenance Culture Method for Intestinal Stem Cells Derived from Human Induced Pluripotent Stem Cells. Biological & pharmaceutical bulletin. 2024. 47. 1. 120-129

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MISC (338)：

竹内正義, 逆井(坂井)亜紀子, 高田尊信, 郡山恵樹, 古川絢子, 瀧野純一, 長嶺憲太郎, 堀隆光, 菊池千草, 堀英生, et al. Effects of toxic AGEs (TAGE) on human health. 日本薬学会年会要旨集(Web). 2023. 143rd
佐藤寛之, 山下美紗季, 坡下真大, 岩尾岳洋, 松永民秀. The functional evaluation of blood-brain barrier model using human iPS cells-derived brain microvascular endothelial cells. 日本薬学会年会要旨集(Web). 2023. 143rd
今井優里, 小川勇, 岩尾岳洋, 岩尾岳洋, 松永民秀, 松永民秀. Development of a co-culture system between lactic acid bacteria and human iPS cell-derived intestinal cells. 日本薬学会年会要旨集(Web). 2023. 143rd
竹内規晃, 山下美紗季, 坡下真大, 坡下真大, 岩尾岳洋, 岩尾岳洋, 常喜祥子, 広瀬賢一, 山中誠, 小柳博, et al. Development of BBB-on-a-chip using human iPS cell-derived brain microvascular endothelial cells. 日本薬学会年会要旨集(Web). 2023. 143rd
蓑輪華子, 白井晃太郎, 岩尾岳洋, 岩尾岳洋, 松永民秀, 松永民秀. Improvement of differentiation method of human iPS cell-derived small intestinal epithelial cells for pharmacokinetic evaluation. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (12)：

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Books (2)：

臓器チップの技術と開発動向
シーエムシー出版 2018
薬剤学実験法必携マニュアル -Pharmaceutical Scientistのために-
日本薬剤学会,南江堂 2014

Professional career (1)：

九州大学大学院薬学研究科衛生化学・裁判化学/博士(薬学)

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