Research field (5):
Cell biology
, Pharmaceuticals - chemistry and drug development
, Pharmacology
, Pharmaceuticals - health and biochemistry
, Clinical pharmacy
Research keywords (3):
分化
, 肝細胞
, ヒトiPS細胞
Research theme for competitive and other funds (41):
2019 - 2023 Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms
2019 - 2022 Creation of pharmacokinetics and toxicity prediction model system using human iPS cell-derived small intestinal cells and tissues
2019 - 2022 Factors involved in the efficacy and safety of biopharmaceuticals
2017 - 2020 The construction of a blood-brain barrier model using novel human iPS cell-derived endothelial progenitor cells
2016 - 2020 Generation and accumulation of intracellular toxic advanced glycation end-products due to modern dietary habits and elucidation of relevant cytotoxic mechanisms
2016 - 2019 Biofabrication of functional 3D tissues
2016 - 2019 Study of the infusion reaction by rituximab
2016 - 2019 Monitoring of transplanted hepatocytes and analysis of immune rejection responses in the hepatocyte chimeric mouse system.
2016 - 2018 Construction of a model for intestinal toxicity test using human and monkey iPS cells and search for toxic biomarker
2014 - 2017 Differentiation of human iPS cells into hepatocytes and enterocytes: Development of first pass effect assessment model
2014 - 2017 Elucidating the mechanism of vascular dysfunction to achieve gender-specific medicine
2014 - 2016 Establishment of induced pluripotent stem cells from glycogen storage disease type Ib patient and making disease models
2013 - 2016 Development and clinical evaluation of hepatitis onset model of chimeric mice with iPS-derived human hepatocytes
2013 - 2016 Investigation of the infusion reaction development coursed by molecular target medicine prescription
2011 - 2014 Generation of Monkey/Mouse Chimera with Monkey Liver by Interspecific Blastocyst Injection of Monkey induced Pluripotent Stem Cells
2011 - 2013 Mechanism of vascular dysfunction with continuous hyperglicemia or postprandial hyperglycemia and development of treatment strategy
2010 - 2012 Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development study
2010 - 2012 Chemopreventive effects of vitamin K cycle using human iPS cells
2008 - 2010 ヒト胎児肝細胞におけるCYP3A分子種の発現変動要因の解明
2006 - 2007 妊娠と薬:胎児における薬物動態変動因子の解明
2005 - 2006 サル胚性幹細胞の肝細胞への分化と胎児薬物動態予測モデルの構築
2004 - 2005 Basic Study for Regenerative Medicine : Differentiate of Human Fetal Liver Cells and Application for Drug Pharmacokinetic Experiments
2003 - 2005 Basic Study for Regenerative Medicine : Differentiate of Embryonic Stem Cells to Hepatocytes and Expressions of Cytochrome P450 in the Differentiating Cells
1998 - 1999 Structures and Function of Novel Esterase and Amidohydrolase
1998 - 1999 Structure and Function of NAD/NADP Requirement Microsomal Alcohol Dehydrogensase
1989 - 1990 Nobel Mechanism in Xenobiotic Metabolism-Oxygenation of Aldehydes to Carboxylic Acids
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Papers (192):
Takumi Yago, Naoki Yuda, Miyuki Tanaka, Takahiro Iwao, Tamihide Matsunaga. Evaluating intestinal absorption of peptide Met-Lys-Pro in casein hydrolysate using Caco-2 and human iPS cell-derived small intestinal epithelial cells. Food research international (Ottawa, Ont.). 2024. 193. 114831-114831
竹内正義, 逆井(坂井)亜紀子, 高田尊信, 郡山恵樹, 古川絢子, 瀧野純一, 長嶺憲太郎, 堀隆光, 菊池千草, 堀英生, et al. Effects of toxic AGEs (TAGE) on human health. 日本薬学会年会要旨集(Web). 2023. 143rd
佐藤寛之, 山下美紗季, 坡下真大, 岩尾岳洋, 松永民秀. The functional evaluation of blood-brain barrier model using human iPS cells-derived brain microvascular endothelial cells. 日本薬学会年会要旨集(Web). 2023. 143rd
今井優里, 小川勇, 岩尾岳洋, 岩尾岳洋, 松永民秀, 松永民秀. Development of a co-culture system between lactic acid bacteria and human iPS cell-derived intestinal cells. 日本薬学会年会要旨集(Web). 2023. 143rd
竹内規晃, 山下美紗季, 坡下真大, 坡下真大, 岩尾岳洋, 岩尾岳洋, 常喜祥子, 広瀬賢一, 山中誠, 小柳博, et al. Development of BBB-on-a-chip using human iPS cell-derived brain microvascular endothelial cells. 日本薬学会年会要旨集(Web). 2023. 143rd