Research keywords (6)：
癌免疫学
, 肝臓病学
, 消化器内科学
, Cancer Immunology
, Hepatology
, Gatsroenterology
Research theme for competitive and other funds (37)：
2021 - 2024 ドライバー遺伝子異常に基づいた肝がん個別化薬物療法の構築
2021 - 2024 Elucidation of hepatic progenitor cell-derived carcinogenic mechanism via p53 activation in hepatocytes
2020 - 2023 The effect of elevated TNF-alfa on the pathogenesis of chronic pancreatitis
2020 - 2023 Elucidation of regulatory mechanism of cancer microenvironment through stromal cell autophagy in hepatocellular carcinoma
2020 - 2023 Intracellular transport in the progress of chronic liver disease
2017 - 2020 The effect of insulin insufficiency and/or insulin resistance on pancreatic carcinogenesis and progression
2017 - 2020 Intracellular trafficking in liver disease
2017 - 2020 Elucidation of the effect of mitochondrial DNA release by Bak/Bax activation on chronic liver disease
2017 - 2020 Discovery of HCC progression-related cancer genes through in vivo forward genetic screen
2017 - 2020 Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy
2016 - 2018 Examination of the mechanisms of which radiation induces liver disorder for expanding radiation therapy
2016 - 2018 Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes
2014 - 2018 The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis
2015 - 2017 Development of a liver carcinogenesis model using human hepatocytes and searching suitable anti-cancer drugs considering mutated genes.
2014 - 2017 Intracellular trafficking in the liver
2014 - 2016 Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression
2013 - 2016 The role of NK cell in the patients with hepatitis C virus infection; analysis focusing on NK cell receptor and IFN signal transducer
2013 - 2015 肥満に伴う慢性肝疾患NAFLDにおける免疫の関与とその制御に関する解析
2012 - 2015 Regulation of liver innate immunnity in human hepatocellular carcinoma
2012 - 2015 Continuous hepatocyte apoptosis induces HCC in the liver
2012 - 2014 Molecular mechanisms of acinar cell injury in acute pancreatitis
2011 - 2014 Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.
2012 - 2012 肝細胞CTGFによる肝線維化・肝発癌制御機構の解明
2009 - 2011 Bcl-2 network and regulation of cell death in non-alcoholic steatohepatitis
2009 - 2011 Immunological analysis of liver cancer stem cells and immunotherapy
2008 - 2010 Mechanisms for hepatitis B virus replication and mutagenesis : investigations using virus-expressing mouse system.
2008 - 2010 Molecular mechanism of the ectodomain shedding of the NKG2D ligand MHC class I-related chain A in hepatocellular carcinoma and its therapeutic implication
2005 - 2006 CTL immuno-monitoring in chronic hepatitis C
2005 - 2006 Molecular analysis of dendritic cell based vaccines against liver cancer
2004 - 2005 Natural killer receptor-mediated regulation of dendritic cell functions in chronic hepatitis C
2000 - 2001 Therapeutic strategy for hepatocellular carcinoma by dendritic cell-based tumor vaccination
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Papers (352)：
Shusuke Kumazaki, Hayato Hikita, Yuki Tahata, Ji Hyun Sung, Kenji Fukumoto, Yuta Myojin, Sadatsugu Sakane, Kazuhiro Murai, Yoichi Sasaki, Kumiko Shirai, et al. Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis. Alimentary pharmacology & therapeutics. 2024
Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Tatsuya Sakamoto, Ryohei Narumi, Jun Adachi, Naruyasu Kakita, Yukinori Yamada, Hidenori Toyoda, Hirokazu Takahashi, et al. Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatology communications. 2024. 8. 6
Katsuhiko Sato, Hayato Hikita, Minoru Shigekawa, Kazumasa Soma, Ryohei Yamauchi, Jihyun Sung, Seiya Kato, Yoichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, et al. The serum tenascin C level is a marker of metabolic disorder-related inflammation affecting pancreatic cancer prognosis. Scientific reports. 2024. 14. 1. 12028-12028
Kazuhiro Murai, Hayato Hikita, Takahiro Kodama, Masaki Kaibori, Yuki Nishimura, Tomohide Tatsumi, Tomomi Yamada, Tatsuya Kanto, Satoshi Mochida, Tetsuo Takehara. The impact of the COVID-19 pandemic on hepatocellular carcinoma diagnosis and treatment in Japan: A multicenter collaborative observational study. Hepatology research : the official journal of the Japan Society of Hepatology. 2024. 54. 5. 439-450
Makoto Fukuoka, Takahiro Kodama, Kazuhiro Murai, Hayato Hikita, Emi Sometani, Jihyun Sung, Akiyoshi Shimoda, Satoshi Shigeno, Daisuke Motooka, Akira Nishio, et al. Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells. Cancer science. 2024. 115. 3. 859-870
1986 - 1992 Osaka University Faculty of Medicine Medical School
Professional career (2)：
MD (大阪大学)
PhD (大阪大学)
Committee career (5)：
2012/12 - 現在 日本内科学会近畿支部 評議員
2012/06 - 現在 日本肝臓学会 評議員
2012/01 - 現在 日本消化器病学会 学会評議員
2007/12 - 現在 日本肝臓学会西部会 評議員
2007/01 - 現在 日本消化器病学会近畿支部 評議員
Awards (7)：
2010 - 日本肝臓学会 第3回「CHUGAI Award」
2010 - The Japan Society of Hepatology 「CHUGAI Award」3rd
2006 - 平成17年度財団法人ウイルス肝炎研究財団研究奨励金
2005 - (財)大阪対ガン協会平成16年度ガン研究助成
2004 - (財)大阪対ガン協会平成15年度ガン研究助成
2000 - 第8回浜名湖シンポジウム研究奨励賞
2000 - The 8th Hamanako Sypojium Research Award
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Association Membership(s) (5)：
日本癌学会
, JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY
, The Japan Society of Hepatology
, The Japanese Society of Gastroenterology
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
