Research theme for competitive and other funds (21):
2022 - 2025 Transport mechanism of S-adenosyl-L-methionine into vacuole, elucidation of its physiological function and development of its application
2022 - 2025 Elucidation of molecular basis of Streptomyces signaling-molecule-dependent regulatory pathway and activation of silent secondary metabolite biosynthetic genes
2020 - 2023 ケミカルジェネティクスによるミズクラゲの変態制御シグナル分子群の解明
2018 - 2021 Development of synthesis processes of raw material and carbon fiber composite material contributing to environmental conservation
2019 - 2020 Creation and structural redesign of microbial secondary metabolites through rational modification of metabolic pathways
2016 - 2019 Integration of structural basis for secondary metabolite biosynthesis, regulation, and morphological development coded on the Streptomyces genome
2016 - 2018 Engineering phosphorus metabolic pathway for biological containment of genetically modified microorganisms
2017 - 2018 Mechanistic study and biosynthetic redesign of silent secondary metabolites produced by rational modification of metabolic pathway
2016 - 2017 Collective activation of silent biosynthetic pathways for bioactive compounds by small diffusible signaling molecules
2013 - 2015 Analysis of secondary metabolite regulatory system and construction of the biosynthetic platform by multiple regulatory control
Zhang, Mingge, Shuang, Bao, Arakawa, Kenji. Accumulation of lankamycin derivative with a branched-chain sugar from a blocked mutant of chalcose biosynthesis in Streptomyces rochei 7434AN4. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2023. 80
Abul Taher Mohammed Rafiqul Islam, Keita Shinzato, Hiroki Miyaoka, Kenji Komaguchi, Kanae Koike, Kenji Arakawa, Kenji Kitamura, Nobukazu Tanaka. Isolation and characterization of blackish-brown BY2-melanin accumulated in cultured tobacco BY-2 cells. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 4. 395-410
Iwakuni Miyuki, Suzuki Toshihiro, Yamamoto Shouji, Sasaki Hiroaki, Kinashi Haruyasu, Arakawa Kenji. 2P-229 Functional analysis of srrB, a represser gene that negatively regulates antibiotic production in Streptomyces rochei. 2014. 66. 164-164
Kunitake Hirofumi, Hiramatsu Takahiro, Kinashi Haruyasu, Arakawa Kenji. 2P-226 Structural elucidation and biosynthetic pathway of azoxyalkene produced by a multiple gene disruptant of Streptomyces rochei. 2014. 66. 163-163
Cao Zhisheng, Yoshida Ryuhei, Kataoka Yusuke, Kinashi Haruyasu, Arakawa Kenji. 2P-225 Structural elucidation, biosynthesis, and their regulatory system of the secondary metabolites produced by the blocked mutant of lankacidin biosynthesis of Streptomyces rochei. 2014. 66. 163-163
Hadae Nozomi, Tsuda Naoto, Kinashi Haruyasu, Arakawa Kenji. 2P-228 Functional analysis of a P450 enzyme SrrO involved in the biosynthesis of SRB molecule, an inducer of antibiotic production in Streptomyces rochei. 2014. 66. 163-163
Promotion of antibiotics production by the disruption of the gene for tetR type receptor in Streptomyces rochei
Books (3):
Natural Products from Actinomycetes - Diversity, Ecology and Drug Discovery -
Springer Nature 2022 ISBN:9789811661327
応用微生物学 第3版
文永堂出版 2016
Giant Vesicles
John Wiley & Sons Ltd., Sussex, England 1999
Lectures and oral presentations (68):
The butenolide-type Streptomyces signaling molecule; biosynthesis, its dependent regulatory pathway, and biological activity
(Heinz G. Floss Memorial Symposium on Chemical Biology 2023)
Isolation and biosynthesis of hydrazide-alkenes from an azoxy-alkene-producing mutant of Streptomyces rochei 7434AN4 through genome mining approach
(OSU Symposium 2023)
Exploring and extensive utilization of microorganism for sustainable bioactive natural product discovery
(University of San Carlos-Hiroshima University International Biosymposium 2023 2023)
Exploring and extensive utilization of microorganism through various "genome mining" approaches for sustainable bioactive natural product discovery
(International Conference on Sciences, Technology, and Education, 2023 (ICSTE-2023) 2023)
Manipulation of signaling molecule dependent regulatory pathway for genome mining
(50th KMB Annual Meeting & International Symposium 2023)
1997 - 1999 Tokyo Institute of Technology Department of Chemistry Graduate School, Division of Science and Engineering
1997 - 1999 Tokyo Institute of Technology Graduate School, Division of Science and Engineering Department of Chemistry
1995 - 1997 Tokyo Institute of Technology Department of Chemistry Graduate School, Division of Science and Engineering
1995 - 1997 Tokyo Institute of Technology Graduate School, Division of Science and Engineering Department of Chemistry
1991 - 1995 Tokyo Institute of Technology Department of Chemistry Faculty of Science
1991 - 1995 Tokyo Institute of Technology Faculty of Science Department of Chemistry
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Professional career (2):
Doctor of Science (Tokyo Institute of Technology)
Master of Science (Tokyo Institute of Technology)
Work history (9):
2024/04/01 - Hiroshima University Graduate School of Integrated Sciences for Life Professor
2019/04/01 - 2024/03/31 Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor
2010/09/01 - 2019/03/31 Hiroshima University Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter Associate Professor
2007/04/01 - 2010/08/31 Hiroshima University Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter Research Assistant Professor
2002/04/01 - 2007/03/31 Hiroshima University Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter Research Assistant Professor
1999/11/01 - 2002/03/31 University of Washington Department of Chemistry, Faculty of Science Research Associate
1999/10/01 - 1999/10/31 JSPS Research Fellow (PD)
1999/10/01 - 1999/10/31 JSPS Research Fellow (PD)
1999/01/01 - 1999/09/30 JSPS Research Fellow (DC)
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Committee career (21):
2023/04 - 2024/03 Society of Actinomycetes Japan Chair of the 37th Annual Meeting of Society of Actinomycetes Japan
2009/07 - Hamada Award Characterization of the biosynthetic gene clusters located on the Streptomyces linear plasmid
2001/03 - Tejima Doctoral Dissertation Memorial Award Synthesis and characterization of archaeal macrocyclic membrane lipids
Association Membership(s) (5):
American Chemical Society
, The Chemical Society of Japan
, The Society for Actinomycetes Japan
, The Society for Biotechnology, Japan
, Japan Society for Bioscience, Biotechnology, and Agrochemistry