Rchr
J-GLOBAL ID：200901099336741399   Update date: Jun. 30, 2024

Arakawa Kenji

アラカワ ケンジ | Arakawa Kenji
Affiliation and department：
Hiroshima University .Program of Biotechnology, Graduate School of Integrated Sciences for Life

About Hiroshima University .Program of Biotechnology, Graduate School of Integrated Sciences for Life


Job title： Professor
Research field  (1)： Bioorganic chemistry
Research keywords  (3)： Secondary metabolites ,  Genome mining ,  Regulation of secondary metabolism
Research theme for competitive and other funds  (22)：
  • 2024 - 2027 Establishment of international academic basis for functional enhancement of natural products toward healthy-aging and a treatment against tropical infectious diseases
  • 2022 - 2025 Transport mechanism of S-adenosyl-L-methionine into vacuole, elucidation of its physiological function and development of its application
  • 2022 - 2025 Elucidation of molecular basis of Streptomyces signaling-molecule-dependent regulatory pathway and activation of silent secondary metabolite biosynthetic genes
  • 2020 - 2023 ケミカルジェネティクスによるミズクラゲの変態制御シグナル分子群の解明
  • 2018 - 2021 Development of synthesis processes of raw material and carbon fiber composite material contributing to environmental conservation
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Papers (90)：
  • Awet Alem Teklemichael, Aiko Teshima, Asahi Hirata, Momoko Akimoto, Mayumi Taniguchi, Gholam Khodakaramian, Takashi Fujimura, Fuyuki Tokumasu, Kenji Arakawa, and Shusaku Mizukami. Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library. Tropical Medicine and Health. 2024
  • Rukman Muslimin, Alimuddin Ali, Sho Ogaki, Nurjannah, Ummu Kalsum Alam, Sisun Choi, Eung-Soo Kim, and Kenji Arakawa. Detection of seco-macrotetrolides caused by regiospecific hydrolysis in Indonesian Streptomyces strains isolated at the karst area in Sulawesi Island. Tetrahedron. 2024. 160. 134045-134045
  • Yu Tanaka, Haruka Nagano, Mei Okano, Takuya Kishimoto, Ayaka Tatsukawa, Hirofumi Kunitake, Atsushi Fukumoto, Yojiro Anzai, Kenji Arakawa. Isolation of Hydrazide-alkenes with Different Amino Acid Origins from an Azoxy-alkene-Producing Mutant of Streptomyces rochei 7434AN4. Journal of Natural Products. 2023. 86. 9. 2185-2192
  • Yuya Misaki, Tomomi Hirashima, Karin Fujii, Asahi Hirata, Yutaro Hoshino, Miho Sumiyoshi, Sachiko Masaki, Toshihiro Suzuki, Kuninobu Inada, Hiroki Koyama, et al. 4-Methoxy-2,2′-bipyrrole-5-carbaldehyde, a biosynthetic intermediate of bipyrrole-containing natural products from the Streptomyces culture, arrests the strobilation of moon jellyfish Aurelia coerulea. Frontiers in Marine Science. 2023. 10
  • 手島 愛子, 平田 朝陽, 荒川 賢治. 放線菌の二次代謝誘導を司るブテノライド型シグナル分子の分子基盤と生合成機構. アグリバイオ. 2023. 7. 3. 233-236
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MISC (7)：
  • 山本徹也, 高橋侑椰, 荒川賢治, 住吉美保. カチオン性低分子ポリスチレンが微生物に及ぼす影響. 化学工学会年会研究発表講演要旨集(CD-ROM). 2018. 83rd. ROMBUNNO.O113
  • Iwakuni Miyuki, Suzuki Toshihiro, Yamamoto Shouji, Sasaki Hiroaki, Kinashi Haruyasu, Arakawa Kenji. 2P-229 Functional analysis of srrB, a represser gene that negatively regulates antibiotic production in Streptomyces rochei. 2014. 66. 164-164
  • Kunitake Hirofumi, Hiramatsu Takahiro, Kinashi Haruyasu, Arakawa Kenji. 2P-226 Structural elucidation and biosynthetic pathway of azoxyalkene produced by a multiple gene disruptant of Streptomyces rochei. 2014. 66. 163-163
  • Cao Zhisheng, Yoshida Ryuhei, Kataoka Yusuke, Kinashi Haruyasu, Arakawa Kenji. 2P-225 Structural elucidation, biosynthesis, and their regulatory system of the secondary metabolites produced by the blocked mutant of lankacidin biosynthesis of Streptomyces rochei. 2014. 66. 163-163
  • Hadae Nozomi, Tsuda Naoto, Kinashi Haruyasu, Arakawa Kenji. 2P-228 Functional analysis of a P450 enzyme SrrO involved in the biosynthesis of SRB molecule, an inducer of antibiotic production in Streptomyces rochei. 2014. 66. 163-163
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Patents (1)：
  • Promotion of antibiotics production by the disruption of the gene for tetR type receptor in Streptomyces rochei
Books (3)：
  • Natural Products from Actinomycetes - Diversity, Ecology and Drug Discovery -
    Springer Nature 2022 ISBN:9789811661327
  • 応用微生物学 第3版
    文永堂出版 2016
  • Giant Vesicles
    John Wiley & Sons Ltd., Sussex, England 1999
Lectures and oral presentations  (75)：
  • Manipulation of signaling-molecule-dependent regulatory pathway for genome mining and concept for international cooperation
    (International Seminar 2024 on Sciences and Technology 2024)
  • Discovery and biosynthetic investigation of hydrazide-alkenes from an azoxy-alkene-producing mutant of Streptomyces rochei 7434AN4 through genome mining approach
    (2024 Annual Meeting & International Symposium, The Korean Society for Microbiology and Biotechnology 2024)
  • Overview of biosynthetic machinery, structural redesign, regulatory network, genome mining, and natural product discovery in Actinomycetes
    (1st Japan-Korea Actinomycetes Symposium 2024)
  • Natural products discovery through microbial genome mining approaches and extensive investigation of their biosynthetic machineries and biological activities
    (Guest Lecture 2023)
  • Overview of biosynthetic machinery, structural redesign, regulatory network, and genome mining in Actinomycetes
    (Hiroshima University-Inha University International Biosymposium 2023 2023)
ｍore...
Education (6)：
  • 1997 - 1999 Tokyo Institute of Technology Department of Chemistry Graduate School, Division of Science and Engineering
  • 1997 - 1999 Tokyo Institute of Technology Graduate School, Division of Science and Engineering Department of Chemistry
  • 1995 - 1997 Tokyo Institute of Technology Department of Chemistry Graduate School, Division of Science and Engineering
  • 1995 - 1997 Tokyo Institute of Technology Graduate School, Division of Science and Engineering Department of Chemistry
  • 1991 - 1995 Tokyo Institute of Technology Department of Chemistry Faculty of Science
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Professional career (2)：
  • Doctor of Science (Tokyo Institute of Technology)
  • Master of Science (Tokyo Institute of Technology)
Work history (9)：
  • 2024/04/01 - Hiroshima University Graduate School of Integrated Sciences for Life Professor
  • 2019/04/01 - 2024/03/31 Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor
  • 2010/09/01 - 2019/03/31 Hiroshima University Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter Associate Professor
  • 2007/04/01 - 2010/08/31 Hiroshima University Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter Research Assistant Professor
  • 2002/04/01 - 2007/03/31 Hiroshima University Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter Research Assistant Professor
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Committee career (21)：
  • 2023/04 - 2024/03 Society of Actinomycetes Japan Chair of the 37th Annual Meeting of Society of Actinomycetes Japan
  • 2021/05 - 2023/05 日本農芸化学会 日本農芸化学会中四国支部 支部会計幹事
  • 2022/04 - 日本放線菌学会 日本放線菌学会第17期理事
  • 2022/04 - 日本放線菌学会 日本放線菌学会・副会長
  • 2017/06 - 2019/05 公益社団法人 日本生物工学会 英文誌編集委員会委員
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Awards (5)：
  • 2016/04 - 公益財団法人長瀬科学技術振興財団 公益財団法人長瀬科学技術振興財団・長瀬研究振興賞 放線菌ゲノムマイニングにて取得したアゾキシアルケン化合物の特異な分子骨格形成機構の解明
  • 2015/10/14 - 一般財団法人バイオインダストリー協会 2015年度 発酵と代謝研究奨励賞 放線菌二次代謝生合成・制御遺伝子の分子基盤解析および有用物質発酵生産への応用
  • 2013/03/24 - 公益社団法人日本農芸化学会会長 2013年度農芸化学奨励賞
  • 2009/07 - Hamada Award Characterization of the biosynthetic gene clusters located on the Streptomyces linear plasmid
  • 2001/03 - Tejima Doctoral Dissertation Memorial Award Synthesis and characterization of archaeal macrocyclic membrane lipids
Association Membership(s) (5)：
American Chemical Society ,  The Chemical Society of Japan ,  The Society for Actinomycetes Japan ,  The Society for Biotechnology, Japan ,  Japan Society for Bioscience, Biotechnology, and Agrochemistry
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