Rchr
J-GLOBAL ID：200901099543413105
Update date: Jun. 06, 2020
Ohtake Kazuo
オオタケ カズオ | Ohtake Kazuo
Affiliation and department：
Job title：
Assistant Professor,Assistant Professor
Homepage URL (1)：
http://mail.josai.ac.jp/~cdhn/index.htm
Research field (3)：
Metabolism and endocrinology
, Cardiology
, Gastroenterology
Research keywords (5)：
タイトジャンクション
, 一酸化窒素
, 亜硝酸
, タンパク質ニトロソ化
, protein S-nitrosylation nitrite nitric oxide
Research theme for competitive and other funds (7)：
- 2005 - 2010 亜硝酸塩による高血圧改善作用に関する研究
- 2005 - 2008 亜硝酸塩による潰瘍性大腸炎改善作用に関する研究
- 2005 - 2007 Dietary nitrite inhibits early glomerular injury in streptozotocin-induced diabetic nephropathy in rats
- 2004 - 2007 胃粘膜のS-ニトロソ化タンパク質のプロテオミクス解析
- 1996 - 2004 ポリカチオン性物質(キトサン、ポリ-L-アルギニン)による上皮細胞間隙透過性増大機構に関する研究
- 亜硝酸塩による糖尿病性腎症改善作用に関する研究
- 吸収促進剤を利用した水溶性高分子薬物(生理活性ペプチド、ホルモン、ワクチン、DNA)の経鼻薬物送達、特に鼻粘膜上皮細胞の細胞間隙経路(tight junction)からの吸収を高める方法
Show all
MISC (10)：
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Ohtake K, Shimada N, Uchida H, Kobayashi J. Proteomic approach for identification of protein S-nitrosation in mouse gastric mucosa treated with S-nitrosoglutathione. J Proteomics. 2009. 21. 75. 750-760
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Kazuo Ohtake, Yuichi Ishlyama, Hiroyuki Uchida, Etsuko Muraki, Jun Kobayashi. Dietary nitrite inhibits early glomerular injury in streptozotocin-induced diabetic nephropathy in rats. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2007. 17. 2. 75-81
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Poly-L-Arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro. Pharmaceutical Research. 2003. 20, 153-160
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Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium. Pharmaceutical Research. 2003. 20, 1838-45
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Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats. Journal of Controlled Release. 2002. 82, 263-275
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Works (2)：
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ニトロソ化たん白質の新規定量法に関する研究
2004 -
-
鼻粘膜からの高分子薬物の吸収
1999 - 2001
Education (4)：
- - 2000 Josai University Graduate School, Division of Pharmaceutical Sciences
- - 2000 Josai University Graduate School, Division of Pharmaceutical Sciences
- - 1997 Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
- - 1997 Josai University Faculty of Pharmaceutical Science
Professional career (1)：
Awards (1)：
- 1998 - The Nagai Foundation Tokyo CRS Graduate Student Award 1998
Association Membership(s) (4)：
日本NO学会
, 日本潰瘍学会
, 日本栄養・食糧学学会
, 日本薬学会
