Rchr
J-GLOBAL ID：200901099708630610   Update date: Jan. 30, 2024

Hirose Yutaka

ヒロセ ユタカ | Hirose Yutaka
Affiliation and department：
Laboratory of Gene Regulation, Graduate School of Medicine and Pharmaceutical Sciences

About Laboratory of Gene Regulation, Graduate School of Medicine and Pharmaceutical Sciences


Job title： Associate Professor
Research field  (2)： Molecular biology ,  Functional biochemistry
Research theme for competitive and other funds  (24)：
  • 2017 - 2020 Regulation of mRNA metabolism by the transcription-coupled RNA methyltransferase PCIF1
  • 2012 - 2017 Study of transcriptional cycle regulation via in vitro reconstitution
  • 2008 - 2010 Investigation of the mechanism by which novel phosphorylated RNA polymerase II-interacting factors coordinate processes required for gene expression
  • 2005 - 2009 Unified crosstalk of signal transduction, chromatin regulation, and RNA processing by transcription complexes
  • 2005 - 2006 RNAポリメラーゼIICTDリン酸化制御による転写とRNAプロセシングの協調機構
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Papers (31)：
  • Ai Sugita, Soichiro Kuruma, Natsuki Yanagisawa, Hiroyasu Ishiguro, Ryoya Kano, Yoshiaki Ohkuma, Yutaka Hirose. The cap-specific m(6)A methyltransferase, PCIF1/CAPAM, is dynamically recruited to the gene promoter in a transcription-dependent manner. JOURNAL OF BIOCHEMISTRY. 2021. 170. 2. 203-213
  • Yuri A. Zarate, Tomoko Uehara, Kota Abe, Masayuki Oginuma, Sora Harako, Shizuka Ishitani, Anna-Elina Lehesjoki, Tatjana Bierhals, Katja Kloth, Nadja Ehmke, et al. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants. GENETICS IN MEDICINE. 2021. 23. 6. 1050-1057
  • Shinichiro Akichika, Seiichi Hirano, Yuichi Shichino, Takeo Suzuki, Hiroshi Nishimasu, Ryuichiro Ishitani, Ai Sugita, Yutaka Hirose, Shintaro Iwasaki, Osamu Nureki, et al. Cap-specific terminal N-6-methylation of RNA by an RNA polymerase II-associated methyltransferase. SCIENCE. 2019. 363. 6423. 141-141
  • Seiji Yamamoto, Tomoko Hagihara, Yoshiyuki Horiuchi, Akira Okui, Shotaro Wani, Tokuyuki Yoshida, Takao Inoue, Aki Tanaka, Takashi Ito, Yutaka Hirose, et al. Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-B and C/EBP on stimulation of Toll-like receptor 9. GENES TO CELLS. 2017. 22. 3. 265-276
  • Shotaro Wani, Ai Sugita, Yoshiaki Ohkuma, Yutaka Hirose. Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation. JOURNAL OF BIOCHEMISTRY. 2016. 160. 2. 111-120
ｍore...
MISC (5)：
  • 廣瀬 豊. RNAポリメラーゼII-CTDリン酸化による遺伝子発現過程の協調機構. 生化学. 2010. 221-231
  • 広瀬 豊. mRNAの転写伸長・プロセシングのダイナミズム. 化学と生物. 2005. 43. 6. 366-374
  • 広瀬 豊. リン酸化によるRNAポリメラーゼ2の機能制御とヒト神経疾患 (特集 タンパク質リン酸化調節異常と疾患). モレキュラ-メディシン. 2004. 41. 5. 551-559
  • 原田 文夫, 木戸 敬治, 広瀬 豊, 黒木 和之. 4.5S RNA_HとhnRNP A1及びC蛋白質の特異的結合. 日本分子生物学会年会プログラム・講演要旨集. 1996. 19. 36-36
  • 木戸 敬治, 広瀬 豊, 黒木 和之, 原田 文夫. hnRNP A1およびCタンパク質の4.5S RNA_H結合部位. 日本分子生物学会年会プログラム・講演要旨集. 1996. 19. 461-461
Education (4)：
  • - 1989 Kanazawa University
  • - 1989 Kanazawa University Graduate School, Division of Medicine
  • - 1985 Nagoya University School of Science
  • - 1985 Nagoya University Faculty of Science
Professional career (2)：
  • Master of Science (Kanazawa University)
  • Doctor(Medicine) (Kanazawa University)
Work history (4)：
  • 2009/10 - 現在 University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences
  • 2006/04 - 2009/09 University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences
  • 1989/04 - 2006/03 金沢大学がん研究所 生物物理部 助手
  • 1995/05 - 1998/05 米国コロンビア大学 生物学部 Visiting Researcher
Awards (4)：
  • 2006 - 平成18年度細胞科学研究財団研究助成金
  • 2000 - 平成11年度ノバルティス研究奨励金
  • 2000 - 第31回内藤記念科学奨励金
  • 1999 - 第13回 北國がん基金助成
Association Membership(s) (5)：
日本RNA学会 ,  日本分子生物学会 ,  the RNA Society ,  the Pharmaceutical Society of Japan ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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