Rchr
J-GLOBAL ID：200901099805236005   Update date: Dec. 10, 2024

Takahama Yousuke

タカハマ ヨウスケ | Takahama Yousuke
Affiliation and department：
National Cancer Institute, NIH Experimental Immunology Branch

About National Cancer Institute, NIH Experimental Immunology Branch


Job title： Senior Investigator
Homepage URL  (1)： https://ccr.cancer.gov/staff-directory/yousuke-takahama
Research field  (1)： Immunology
Research keywords  (3)： Immune System ,  Thymus ,  T lymphocyte
Research theme for competitive and other funds  (45)：
  • 2016 - 2019 Positive selection of T cells in the thymic cortex
  • 2014 - 2017 Positive selection dictates T cell-mediated body defense
  • 2012 - 2017 Development and function of thymic microenvironments
  • 2012 - 2017 Analysis and Synthesis of Multidimensional Immune Organ Network
  • 2011 - 2014 Molecular basis for the thymic microenvironments that characterize the immune system
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Papers (80)：
  • Graham Anderson, Emilie J Cosway, Kieran D James, Izumi Ohigashi, Yousuke Takahama. Generation and repair of thymic epithelial cells. The Journal of experimental medicine. 2024. 221. 10
  • Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C Kelly, Naozumi Ishimaru, Yousuke Takahama. Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance. Cell Reports. 2024. 43. 4. 114072-114072
  • Izumi Ohigashi, Andrea J White, Mei-Ting Yang, Sayumi Fujimori, Yu Tanaka, Alison Jacques, Hiroshi Kiyonari, Yosuke Matsushita, Sevilay Turan, Michael C Kelly, et al. Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium. eLife. 2024. 12
  • Ryonosuke Fujie, Kaoru Kurowarabe, Yuki Yamada, Kakeru Fujiwara, Hayato Nakatani, Kenta Tsutsumi, Ryota Hayashi, Hinami Kawahata, Megumi Miyamoto, Madoka Ozawa, et al. Endogenous CCL21-Ser deficiency reduces B16-F10 melanoma growth by enhanced antitumor immunity. Heliyon. 2023. 9. 8. e19215-e19215
  • Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M Taketo, Yousuke Takahama, Shinji Takada. Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development. eLife. 2022. 11. e69088
ｍore...
MISC (47)：
  • Yousuke Takahama. The thymoproteasome in shaping the CD8+ T-cell repertoire. Current Opinion in Immunology. 2023. 83. 102336-102336
  • 牛尾綾, LENNIKOV Mami, 大塚邦紘, 常松貴明, 石丸直澄, 高濱洋介. The layer protection of heterogeneous medullary thymic epithelial cells for autoimmune disease. 日本病理学会会誌. 2023. 112. 1. 243-243
  • Izumi Ohigashi, Mami Matsuda-Lennikov, Yousuke Takahama. Large-Scale Isolation of Mouse Thymic Epithelial Cells. Methods in Molecular Biology (Clifton, N.J.). 2023. 2580. 189-197
  • Mami Matsuda-Lennikov, Izumi Ohigashi, Yousuke Takahama. Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells. Current Opinion in Immunology. 2022. 77. 102217-102217
  • Yousuke Takahama. mTEC damage risks immune recovery. Journal of Experimental Medicine. 2022. 219. 2
ｍore...
Books (3)：
  • Synthetic Immunology
    Springer 2016 ISBN:4431560254
  • Thymic development and selection of T lymphocytes
    Springer 2014 ISBN:9783642402517
  • Your amazing immune system
    Japanese Society for Immunology and European Federation of Immunological Societies 2008
Education (2)：
  • - 1988 Osaka University Graduate School of Medicine
  • - 1982 Tokyo Institute of Technology School of Science Department of Chemistry
Professional career (1)：
  • Doctor of Philosophy in Medical Science (Osaka University)
Work history (9)：
  • 2018 - NCI, NIH Senior Investigator
  • 2016 - The University of Tokushima Institute of Advanced Medical Sciences Director and Professor
  • 2008 - The University of Tokushima Institute for Genome Research Director and Professor
  • 1999 - The University of Tokushima Institute for Genome Research Professor
  • 1997 - JST PRESTO Scientist
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Committee career (6)：
  • 2004 - 現在 Global Thymus Network Founding Organizer
  • 2016 - 2019 International Union of Immunological Societies Council
  • 2016 - 2018 MEXT Science Adviser
  • 2015 - 2018 Federation of Immunological Societies of Asia-Oceania Treasurer
  • 2008 - 2018 Japanese Society for Immunology Board
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Awards (1)：
  • 2000 - Japanese Society for Immunology Award
Association Membership(s) (3)：
American Association of Immunologists ,  Molecular Biology Society of Japan ,  Japanese Society for Immunology
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