Yamanaka Hajime

ヤマナカハジメ | Yamanaka Hajime

Affiliation and department：
Job title： Visiting Researcher

Research field (6)： Neuroscience - general , Neuropathology , Animals: biochemistry, physiology, behavioral science , Laboratory animal science , Medical biochemistry , Molecular biology

Research keywords (13)： depression , Manic-depressive illness (Affective disorder) , primate , serotonin , serotonin 1B receptor (HTR1B) , ketamine , Ventral pallidum , Ventral striatum (Nucleus accumbens) , Basal ganglia , reserpine , PET , spinal cord injury , Parkinson disease

Research theme for competitive and other funds (5)：

2016 - 2020 Verification of the "serotonin 1B receptor hypothesis" using a primate model of depression
2015 - 2020 Elucidation of role of nucleus accumbens for neural circuit reorganization during motor function recovery
2012 - 2016 Elucidation of the role of the nucleus accumbens in motor function recovery after spinal cord injury; neural and molecular basis relating to motivation and plasticity
2009 - 2011 Neuronal and biological bases of the motivation in rehabilitation
2009 - 2011 Pathological mechanism for interferon-induced depression

Papers (21)：

Hajime Yamanaka, Hidetoshi Ishibashi, Katsuki Nakamura. Development of a DSM test battery to determine depression-like marmoset. BioRxiv. 2024
Yu Takata, Hajime Yamanaka, Hiroshi Nakagawa, Masahiko Takada. Morphological changes of large layer V pyramidal neurons in cortical motor-related areas after spinal cord injury in macaque monkeys. Scientific Reports. 2023. 13. 1
Hajime Yamanaka, Yu Takata, Hiroshi Nakagawa, Tomoko Isosaka-Yamanaka, Toshihide Yamashita, Masahiko Takada. An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury. PLOS ONE. 2021. 16. 6. e0252023-e0252023
Yu Takata, Hiroshi Nakagawa, Taihei Ninomiya, Hajime Yamanaka, Masahiko Takada. Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites. Scientific Reports. 2021. 11. 1. 4171
Hajime Yamanaka, Chihiro Yokoyama, Hiroshi Mizuma, Sachi Kurai, Sjoerd J Finnema, Christer Halldin, Hisashi Doi, Hirotaka Onoe. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Translational Psychiatry. 2014. 4. e342

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MISC (21)：

高田裕生, 中川浩, 山中創, 高田昌彦. サル脊髄損傷後の手指機能回復と大脳皮質運動関連領野に分布する巨大錐体細胞の形態について. 理学療法学Supplement. 2020. 47. Suppl.1. B-91_2-B-91_2
高田裕生, 中川浩, 山中創, 高田昌彦. サル脊髄損傷モデルにおける運動機能変化と運動関連領野5層巨大錐体細胞の形態学的変化の関係について. 理学療法学. 2019. 46. Suppl.1. O2-6
高田裕生, 中川浩, 山中創, 高田昌彦. Morphological differences of large layer V pyramidal neurons in the cortical motor-related areas of the primate models of spinal cord injury. 2019
H. Onoe, H. Yamanaka, C. Yokoyama, H. Mizuma, S. J. Finnema, H. Doi, C. Halldin. Increase in 5-HT1B receptors in nucleus accumbens and ventral pallidum by ketamine as its possible mechanism of antidepressant action: PET study with rhesus monkeys. European Journal of Nuclear Medicine and Molecular Imaging. 2014. 41. S215-S215
山中創, 横山ちひろ, 水間広, 大野正裕, 武田千穂, 森智子, Finnema Sjoerd J., Halldin Christer, 土居久志, 尾上浩隆. ケタミンの抗うつ作用メカニズムに側坐核と腹側淡蒼球のセロトニン1Bレセプターが関与する可能性マカクザルを用いたPET研究. JSMI Report. 2014. 7. 2. 94-94

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Lectures and oral presentations (35)：

うつ病研究の現状と新しいうつ病研究の起爆剤
(第 24 回活性アミンに関するワークショップ 2022)
サルを多面的に見つめてうつ病研究を推進するツール
(第5回食欲・食嗜好研究会 2020)
A test battery to assess depression-like behaviours in common marmosets
(2019)
Effect of repetitive transcranial magnetic stimulation combined with anti-RGMa antibody treatment on functional recovery after spinal cord injury in macaques
(2019)
サル脊髄損傷モデルにおける運動機能変化と運動関連領野5層巨大錐体細胞の形態学的変化の関係について
(第23回日本基礎理学療法学会学術大会 2018)

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Education (4)：

1999 - 2003 The Graduate University for Advanced Studies School of Life Science Department of Physiological Sciences
1997 - 1999 国立琉球大学大学院保健学研究科修士課程
1991 - 1996 国立琉球大学医学部保健学科(1996年10月-1997年3月国立琉球大学医学部研究生)
1987 - 1990 愛知県立熱田高校普通科

Professional career (1)：

Doctor of Science (The Graduate University for Advanced Studies, SOKENDAI)

Work history (10)：

2024/10 - 現在 Okinawa Institute of Science and Technology Graduate University Neural Circuit Unit Research Unit Technician
2024/04 - 2024/09 Okinawa Institute of Science and Technology Graduate University (OIST) Neural Circuit Unit Visiting Researcher
2022/12 - 2024/03 Okinawa Institute of Science and Technology Graduate University Neural Computation Research Unit Technician
2022/04 - 2022/11 Okinawa Institute of Science and Technology Graduate University Neural Circuit Unit Visiting Researcher
2016/04 - 2022/03 Kyoto University Primate Research Institute

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Association Membership(s) (3)：

Society for neuroscience , JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY , THE JAPAN NEUROSCIENCE SOCIETY

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