Yamashita Yoshihisa

2020 - 2023 受動喫煙のバイオマーカーとしてのコチニンと幼児・学童のう蝕の関連についての研究

2019 - 2022 Health effects in dental technicians exposed dental indium alloy

2018 - 2021 Oral health and male-female health-survival paradox

2016 - 2021 Molecular epidemiology of virulence of microbiome considering host immune response

2016 - 2020 International comparison study between Japan and Korea aiming at paradigmshift from 8020 to 8028

2016 - 2019 A large-scale survey of tongue microbiota of elderly adults for the development of its maintenance approach

2016 - 2019 Identification of unnamed bacteria species in saliva to elucidate the relationship between oral microbiome and oral health conditions

2015 - 2018 Microbiome analysis of apical periodontitis and cellulitis in oral cavity

2015 - 2017 Research for relationship between oral microboiome and head and neck and digestive organ cancers

2014 - 2017 Development of a novel diagnosis system for periodontal disease by objective biochemical laboratory tests for salivary biomarkers.

2013 - 2016 Exploration of relevant factors of oral microbiome maturation by using molecular approach

2013 - 2016 Reconstruction of oral microflora by riboswitch regulation

2013 - 2016 Elucidation of relationship between the results obtained from comprehesive analysis of oral flora by using a semiconductor sequencer and health condtion

2012 - 2015 Microbial and epidemiological study of aggressive periodontal disease in Moroccan adolescence.

2011 - 2015 Study about causal association between obesity and periodontal disease by athletic epidemiological study using accelerometer

2012 - 2014 Study about changes in oral environment and improvement effects of gum chewing on oral environment in a situation that interrupts routine oral hygiene

2010 - 2014 Study about pathogenic, environmental, and social factors of oral health in adult population by comparing Japan and South Korea

2010 - 2014 A study on analysis of oral microbiota of oral cancer patients and application to management perisurgical period

2013 - 2014 Effect of denture wearing on improving swallowing function in frail elderly people

2010 - 2014 一般住民を対象とする口腔と全身の健康維持との関係に関する総合的研究

2011 - 2013 わが国の健康増進事業の現状把握とその評価および今後のあり方に関する調査研究

2010 - 2013 日本と韓国の国際比較による成人口腔保健に関わる病院・環境および社会背景要因の解明

2011 - 2012 Study of the effect of enteral tube feeding on oral flora

2010 - 2012 The elucidation of the cause of adult caries based on the comprehensive analysis of plaque microbita

2010 - 2012 A retrospective cohort study of the mutual association between periodontal etiology and metabolic syndrome

2009 - 2011 乳酸菌の耐酸性におけるdgk遺伝子の役割

2008 - 2010 Development of periodontal disease-diagnosis kit by nanotechnology and the application for information on health network

2008 - 2010 Investigation of effect of soluble factors from adipose tissue on periodontitis, and development of prophylactic approach with these regulation

2008 - 2010 Study of effect of microflora and moistness of tongue on pyrexia and pneumonia in elderly people who require nursing care

2010 - 摂食機能が高齢者の口腔細菌叢の構成に及ぼす影響の解明

2010 - CATF21Fastの検査結果と歯科臨床症状との関連性に関する研究

2010 - ペチパー抽出物による口臭抑制効果に関する研究

2010 - T-RFLPによる細菌叢分析に関する技術的支援

2009 - 2009 口腔常在細菌の網羅的解析による川崎病特異的口腔フローラの解明

2007 - 2009 Study of effect of oral microflora on oral and general health

2008 - 2008 16S rRNA遺伝子解析によるプラークバイオフィルム形成機序の個体差の解明

2007 - 2008 神経症における歯周炎病態モデルの解明とその予防法の確立

2007 - 2008 Development of Streptococcus mutans eradication therapy with the inhibitor for diacylglycerol kinase activity involved in aciduricity

2007 - 口腔の健康がメタボリックシンドロームに及ぼす影響に関するコホート研究

2007 - ペリオスクリーンによる歯周疾患の診査診断の可能性に関する研究

2006 - 2006 工業生産可能な抗体疑似分子によるバイオフィルムコントロール法の開発

2005 - 2006 Epidemiological studies of the relationships between periodontal diseases and systemic health

2005 - 2006 Binding Affinity of Actinobacillus actinomycetemcomitans for extracellular matrix proteins

2004 - 2006 Establish of clinical evaluation system for measurement of carcinogen (acetaldehyde) derived from oral bacterium

2006 - 乳酸菌飲料の摂取が生活習慣病に及ぼす影響の解明

2005 - 2005 コンビナトリアル・バイオエンジニアリングによるバイオフィルムの形成抑制法の開発

2004 - 2005 Identification of Streptococcus pneumoniae and its antibiotics-resistant gene by using a novel DNA amplification technique

2003 - 2003 口腔局所のアセトアルデヒド(発がん物質)産生因子の解明

2001 - 2003 Study of effect of host nicotine metabolism on progress of periodontitis in smokers

2000 - 2003 Development of new antibiotics targeting cell wall biosynthesis of oral pathogenic bacteria

2003 - 口腔細菌叢と口腔および全身の健康の関連性の解明

2002 - 2002 禁煙支援の効率化を目指した指導指標の確立と要指導者の特定

2001 - 2002 An epidemiological study of the difference of periodontal disease condition in smokers and nonsmokers

2000 - 2000 う蝕細菌のバシトラシン耐性機構の解明

1997 - 2000 Counteractive therapy against the cariogenic bacterium by introduction of antisense-RNA of virulent genes

1995 - 1997 Development of Oral Diagnosis Using Rapid and Simple Quantitative Gene Amplification of Oral Pathogens

1996 - 1996 う蝕細菌の病原因子発現阻害剤によるう蝕予防法の開発

1995 - 1995 う蝕細菌の病原因子遺伝子の発現調節機構に作用するう蝕予防法の開発

1994 - 1994 う蝕細菌の耐酸性因子に対する阻害剤を用いたう蝕予防法の開発

1993 - 1993 齲蝕原性細菌の菌体表層高分子蛋白質を用いた歯面コーティングによる齲蝕予防法の開発

1989 - 1991 mutans streptococciのグルカン合成酵素を用いた齲蝕ワクチンの開発

1990 - 1990 歯周疾患に対するLocal Oxygen Delivery Systemの開発

1987 - 1987 硬組織のアルカリホスファターゼの生理的機能について