Yamashita Motozou

ヤマシタモトゾウ | Yamashita Motozou

Affiliation and department：
Job title： Associate Professor

Research field (5)： Conservative dentistry and endodontics , Regenerative dentistry and dental engineering , Cell biology , Molecular biology , Immunology

Research keywords (14)：歯周病学 , 歯根膜 , Chronic inflammation , 細胞老化 , TGF-beta , 老化 , 歯周組織再生 , オートファジー , ユビキチン , 分子生物学 , 細胞生物学 , Endodontology , 保存修復学 , Periodontal Medicine

Research theme for competitive and other funds (28)：

2023 - 2026 Regulation of Periodontal Tissue Aging - A Novel Strategy for Overcoming Periodontal Disease and Diabetes in the Elderly-
2022 - 2025 歯根膜コラーゲンのプロテオスタシス制御に基づく新規歯周治療法の開発
2022 - 2025 CXCR4/SDF-1 axis ameliorates the impaired wound healing and tissue regeneration in aged periodontal tissue
2023 - 2025 分子接着剤を用いた超効率的な組織再生誘導
2022 - 2024 Longitudinal study of oral health and systemic disease in older identical twins

2021 - 2023 ラマン分光sortingの導入による歯根膜シングルセル解析の高機能化

2019 - 2023 統合オミクス解析に基づく侵襲性歯周炎の病態理解

2020 - 2022 Creation of neo-epigenetic periodontal therapy targeting DNA twist

2019 - 2022 Nano-level multimodal analysis of matrix vesicle-mediated biomineralization

2019 - 2022 Analysis of cellular hierarchy in the periodontal ligament

2019 - 2021 Role of interorganelle communication in mineralization

2018 - 2021 Challenge to the development of new treatments applying the enhancement of periodontal tissue regeneration by controlling stem cell aging

2018 - 2020 Extension of healthy longevity in body and periodontal tissue by NMN supplementation and senolytic treatment

2018 - 2020 Analysis of stem-cell aging by targeting miR-34a-SATB2 axis

2017 - 2020 Development of time controlled therapy for aged periodontal tissue.

2015 - 2019 Identification of genetic risk factors of aggressive periodontitis by genome wide approach

2016 - 2018 Analysis of micro RNA-34a in senescent periodontal ligament cells.

2016 - 2018 Feasible research for novel periodontal regeneration therapeutics by CRISPR/Cas9

2015 - 2018 Effects of cathepsin A on the regeneration of periodontal ligament tissue

2014 - 2017 The effect of cell-derived microparticles on the homeostasis of periodontal tissue

2013 - 2015 Analysis of SASP in chronic periodontal disease

2012 - 2015 Asymmetric stem cell division in the homeostasis and the disease onset of periodontal tissue

2012 - 2015 On demand regulation of tissue regenerative environment at the recipient site of transplantation therapy and dental implant

2011 - 2015 Development of predictive periodontology based on molecular epidemiological study

2011 - 2014 A Challenge to the expansion of indications in periodontal tissue regeneration using FGF-2 by analyzing cross talk between signal molecules

2011 - 2012 Passive smoking-induced epigenetic regulation in tooth・periodontal tissue-associated genes.

2011 - 2012 Defective autophagy in aged periodontal tissue

2009 - 2011 Ubiquitin-proteasome system regulates cytokine signal crosstalk in periodontal stem cells

Show all

Papers (46)：

Motozo Yamashita, Kuniko Ikegami, Tomomi, Nakamura. Regulation of cellular senescence in periodontal tissue. 2024. Vol. 50. 404-405
Koji Miki, Noboru Takeshita, Motozo Yamashita, Masahiro Kitamura, Shinya Murakami. Calcitonin gene-related peptide regulates periodontal tissue regeneration. Scientific reports. 2024. 14. 1. 1344-1344
北垣次郎太, 松本昌大, 藤原千春, 阪下裕美, 平井麻絵, 山下元三, 北村正博, 村上伸也. 歯根膜細胞の骨芽細胞分化におけるカテプシンAの影響. 日本歯科保存学雑誌. 2023. 66. 4. 214-223
Kuniko Ikegami, Motozo Yamashita, Mio Suzuki, Tomomi Nakamura, Koki Hashimoto, Jirouta Kitagaki, Manabu Yanagita, Masahiro Kitamura, Shinya Murakami. Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue. Aging. 2023
Masahiro Kitamura, Motozo Yamashita, Koji Miki, Kuniko Ikegami, Masahide Takedachi, Yoichiro Kashiwagi, Takenori Nozaki, Katsuyuki Yamanaka, Hijiri Masuda, Yoko Ishihara, et al. An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects. Regenerative Therapy. 2022. 21. 104-113

ｍore...

MISC (70)：

北村正博, 山下元三, 三木康史, 池上久仁子, 竹立匡秀, 柏木陽一郎, 野崎剛徳, 増田聖, 石原容子, 山中克之, et al. 特定臨床研究歯周炎を対象とした歯周組織再生剤(REGROTH)と人工骨(Cytrans Granules)の併用療法の安全性及び有効性の評価. 日本歯周病学会会誌. 2021. 63. 秋季特別. 122-122
増田聖, 石原容子, 山中克之, 北村正博, 山下元三, 三木康史, 池上久仁子, 竹立匡秀, 柏木陽一郎, 野崎剛徳, et al. 特定臨床研究歯周炎を対象とした歯周組織再生剤(リグロス)と骨補填材(サイトランスグラニュール)の併用投与に関する安全性評価. 日本歯周病学会会誌. 2021. 63. 秋季特別. 141-141
増田聖, 石原容子, 山中克之, 北村正博, 山下元三, 三木康史, 池上久仁子, 竹立匡秀, 柏木陽一郎, 野崎剛徳, et al. 特定臨床研究:歯周炎を対象とした歯周組織再生剤(リグロス)と骨補填材(サイトランスグラニュール)の併用投与に関する安全性評価. 日本歯周病学会会誌(Web). 2021. 63
Kuniko Ikegami, Motozo Yamashita, Koji Miki, Arisa Nishikawa, Kouki Hashimoto, Tatsuya Morikawa, Noboru Takeshita, Kazunori Ikebe, Masahiro Kitamura, Shinya Murakami. Genetic and Environmental Factors on Periodontitis in Elderly Twins. 第106回アメリカ歯周病学会共催日本歯周学会・日本臨床歯周病学会2020年大会. 2020
西川有彩, 山下元三, 鈴木美麻, 池上久仁子, 中村友美, 橋本康樹, 森川竜也, 北村正博, 村上伸也. ヒト歯根膜細胞のコラーゲン代謝におけるHeat-Shock Proteinsの役割. 日本歯周病学会会誌. 2020. 62. 春季特別. 129-129

ｍore...

Education (2)：

1999 - 現在 Osaka University Graduate School of Dentistry
1995 - 現在 Osaka University School of Dentistry

Work history (10)：

2024/07 - 現在 Osaka University Graduate School of Dentistry
2017/04 - 現在 Osaka University Dental Hospital
2016/10 - 2017/03 Osaka University Graduate School of Dentistry
2009/04 - 2016/09 Osaka University Dental Hospital
2008/05 - 2009/03 Osaka University Dental Hospital

Show all

Committee career (2)：

2022/04 - 現在日本歯周病学会評議員
2017/10 - 現在日本歯科保存学会評議員

Awards (2)：

2015/04 - 大阪大学総長奨励賞
2014/04 - 大阪大学総長奨励賞

Association Membership(s) (6)：

大阪大学歯学会 , IADR , 日本再生医療学会 , 日本分子生物学会 , 日本歯科保存学会 , 日本歯周病学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page