Terawaki Shin-ichi

テラワキシンイチ | Terawaki Shin-ichi

Affiliation and department：
Job title： Senior assistant professor
Homepage URL (1)： https://www.pros.ehime-u.ac.jp/protein-complex/

Research field (1)： Cell biology

Research keywords (6)： Structural biology , X-ray crystallography , クライオ電子顕微鏡 , Signal transduction , Mental disorder , Cancer

Research theme for competitive and other funds (15)：

2022 - 2025 Wntシグナルにおける動的オリゴマー形成に依存した新規なリン酸化制御の構造基盤
2019 - 2022 動的オリゴマー形成因子の分子構造変化によるWntシグナル伝達制御の構造基盤の解明
2016 - 2020 Structural basis for Wnt signaling regulation by dynamic heterooligomer
2013 - 2017 Structural basis of Wnt signaling regulation by dynamic oligomerized proteins
2016 - 2017 Wntシグナル伝達に特異的な動的オリゴマーを標的とするがん治療法の開発

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Papers (29)：

Nobukazu Nameki, Shin-ichi Terawaki, Masayuki Takizawa, Madoka Kitamura, Yutaka Muto, Kanako Kuwasako. Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP. The Journal of Biochemistry. 2023
Carlos Ichiro Kasano-Camones, Masayuki Takizawa, Noriyasu Ohshima, Chinatsu Saito, Wakana Iwasaki, Yuko Nakagawa, Yoshio Fujitani, Ryo Yoshida, Yoshifumi Saito, Takashi Izumi, et al. PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice. The Journal of Biochemistry. 2023. 173. 5. 393-411
Acosta Gonzalez Herik Rodrigo, Nahoko Tomonobu, Haruka Yoneda, Rie Kinoshita, Yosuke Mitsui, Takuya Sadahira, Shin-ichi Terawaki, Yuma Gohara, Ni Luh Gede Yoni Komalasari, Fan Jiang, et al. Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation. Biochemical and Biophysical Research Communications. 2022. 634. 83-91
Kumpei Yamanishi, Marc Fiedler, Shin-Ichi Terawaki, Yoshiki Higuchi, Mariann Bienz, Naoki Shibata. A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to β-catenin. Science signaling. 2019. 12. 611
Kumpei Yamanishi, Yooksil Sin, Shin-ichi Terawaki, Yoshiki Higuchi, Naoki Shibata. High-resolution structure of a Y27W mutant of the Dishevelled2 DIX domain. Acta crystallographica. Section F, Structural biology communications. 2019. 75. Pt 2. 116-122

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Books (1)：

ファルマシア
2016

Lectures and oral presentations (10)：

Axinオリゴマーの構造変化を介したWntシグナル伝達制御の構造基盤
(第95回日本生化学会大会 2022)
Structural basis of the molecular interaction of Axin with Coiled-coil DIX1 by heterotypic oligomerization of DIX domain
(Joint Annual Meeting of 71st JSCB & 19th PSSJ 2019)
Dvl1 DIXドメインによるホモオリゴマー形成機構の構造学的解析
(Wnt研究会2018-2019 2019)
Structural basis for limitation of Ccd1 activity by a unique homomeric interaction in the Wnt pathway
(The 42nd Naito Conference 2016)
Structural basis for limitation of Ccd1 activity by a unique homomeric interaction in the Wnt pathway
(The 42nd Naito Conference 2016)

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Education (3)：

2003 - 2006 Nara Institute of Science and Technology Graduate School of Information Science Department of Bioinformatics and Genomics
2001 - 2003 Nara Institute of Science and Technology Graduate School of Biological Sciences
1997 - 2001 Saga University Faculty of Agriculture Applied Biological Sciences

Professional career (1)：

Ph. D. (Nara Institute of Science and Technology)

Work history (5)：

2022/08 - 現在 Ehime University
2011/04 - 2022/07 Gunma University Graduate School of Science and Technology
2018/03 - 2018/12 Visiting assistant professor, Structural biology, School of Medicine, Stanford university
2008/01 - 2011/03 University of Hyogo
2006/04 - 2007/12 Nara Institute of Science and Technology

Committee career (1)：

2017/04 - 2019/03 日本薬学学会誌ファルマシアトピックス小委員会 D群編集委員

Awards (2)：

2014/09 - 6th Special Neurochemisty Conference Poster Award
2010/04 - リバネス研究費キャリパーライフサイエンス賞微小管依存的な物質輸送を制御するBICDのLabChipGXを活用した構造生物学研究

Association Membership(s) (3)：

日本生化学会 , 日本結晶学会 , 日本蛋白質科学会

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