Rchr
J-GLOBAL ID：201001052769304710   Update date: Oct. 01, 2024

Shimura Takaya

シムラ タカヤ | Shimura Takaya
Affiliation and department：
Nagoya City University Graduate School of Medical Sciences Department of Gastroenterology and Metabolism

About Nagoya City University Graduate School of Medical Sciences Department of Gastroenterology and Metabolism


Job title： Associate Professor
Research field  (3)： Tumor biology ,  Tumor diagnostics and therapeutics ,  Gastroenterology
Research keywords  (1)： バイオマーカー、尿、タンパク、マイクロRNA、エクソソーム、血管新生、微小環境、脂肪細胞、胃癌、大腸癌、食道癌、十二指腸腫瘍、内視鏡、閉塞性大腸癌
Research theme for competitive and other funds  (27)：
  • 2021 - 2024 Novel therapeutic approach for scirrhous gastric cancer targeting complex microenvironment surrounding preadipocytes
  • 2022 - 2024 食道表在癌に対する最適な治療法選択のための革新的血清バイオマーカーの検証
  • 2022 - 2023 尿中タンパクバイオマーカーによる革新的大腸癌スクリーニング診断法の開発
  • 2020 - 2023 胆汁を用いたリキッドバイオプシー研究;エクソソーム解析による胆道疾患の新規解明
  • 2020 - 2023 Urinary circular RNA: novel biomarker for early detection of colorectal cancer
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Papers (199)：
  • Yusuke Okuda, Takaya Shimura, Yuichi Abe, Hiroyasu Iwasaki, Ruriko Nishigaki, Shigeki Fukusada, Naomi Sugimura, Mika Kitagawa, Tamaki Yamada, Ayumu Taguchi, et al. Correction: Urinary dipeptidase 1 and trefoil factor 1 are promising biomarkers for early diagnosis of colorectal cancer. Journal of gastroenterology. 2024. 59. 9. 883-885
  • Peng Zhang, Changjuan Tao, Ye Lu, Peijing Li, Xing Wang, Yujie Dai, Yun Xi, Takaya Shimura, Xinfang Li, Jianmin Fang, et al. Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024. 11. 30. e2400203
  • Makiko Sasaki, Takaya Shimura, Hirotada Nishie, Keita Kuroyanagi, Takuya Kanno, Shigeki Fukusada, Naomi Sugimura, Yusuke Mizuno, Takayuki Nukui, Konomu Uno, et al. BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report. World journal of gastrointestinal oncology. 2024. 16. 7. 3357-3363
  • Yusuke Okuda, Takaya Shimura, Yuichi Abe, Hiroyasu Iwasaki, Ruriko Nishigaki, Shigeki Fukusada, Naomi Sugimura, Mika Kitagawa, Tamaki Yamada, Ayumu Taguchi, et al. Urinary dipeptidase 1 and trefoil factor 1 are promising biomarkers for early diagnosis of colorectal cancer. Journal of gastroenterology. 2024
  • Daigaku Nakamura, Takeshi Yanagita, Yoshiaki Fujii, Kaori Watanabe, Takuya Suzuki, Hajime Ushigome, Ruriko Nishigaki, Naomi Sugimura, Mamoru Tanaka, Ryo Ogawa, et al. Unanticipated pathological clearance in two cases of clinical T4b dMMR/MSI-h advanced colorectal cancer: the potential of immune checkpoint inhibitors despite positive positron-emission tomography results. Surgical case reports. 2024. 10. 1. 105-105
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MISC (73)：
  • Masato Nakamura, Akihito Tsuji, Yoshihiro Okita, Toshihiko Matsumoto, Tamotsu Sagawa, Takanori Watanabe, Kozo Kataoka, Dai Manaka, Kazuhiro Shiraishi, Naoya Akazawa, et al. A multicenter phase 2 trial of ramucirumab plus FOLFIRI as second-line treatment for patients with RAS wild-type metastatic colorectal cancer previously treated with combination chemotherapy with anti-EGFR antibody: JACCRO CC-16. JOURNAL OF CLINICAL ONCOLOGY. 2022. 40. 4
  • 夏目まこと, 志村貴也, 林香月, 片岡洋望. 大網脂肪中のCXCL2を標的とした胃癌腹膜転移に対する新たな分子標的治療法の可能性. 日本消化器病学会雑誌(Web). 2021. 118
  • 志村貴也, 奥田悠介, 岩崎弘靖, 片岡洋望. 消化器癌に対する尿中診断バイオマーカーの現況と将来展望. 消化器・肝臓内科. 2020. 7. 2. 128-135
  • 谷田諭史, 谷田諭史, 尾関啓司, 溝下勤, 福定繁紀, 佐々木槙子, 奥田悠介, 杉村直美, 鈴木健人, 岩崎弘靖, et al. 難治性潰瘍性大腸炎に対するtofacitinib・顆粒球除去強化療法の寛解導入効果の有効性. 日本消化管学会雑誌. 2020. 4. Supplement
  • 志村貴也. 十二指腸腫瘍に対する内視鏡治療 ー表在性非乳頭部十二指腸上皮性腫瘍を中心にー. 第30回日本消化器内視鏡学会東海セミナー. 2020. 29-34
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Patents (6)：
  • 大腸がんバイオマーカーおよびその用途
  • 食道癌の内視鏡治療の適応の判断を補助する方法、診断キット
  • 抗体およびその使用
  • 大腸癌診断用マーカー、大腸癌の診断を補助する方法、大腸癌の診断のためにデータを収集する方法、大腸癌の診断用キット
  • 食道癌バイオマーカー及びその用途
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Lectures and oral presentations  (25)：
  • 胃癌に対するラムシルマブ療法の効果予測因子の同定
    (日本消化器病学会雑誌 2019)
  • The Almost All Colorectal Endoscopic Submucosal Dissection Related Late Local Peritonitis Can Treat Conservatively Without Operation
    (GASTROINTESTINAL ENDOSCOPY 2017)
  • Long-term outcome of transanal colorectal tube for distal stage II/III colorectal cancer with acute colorectal obstruction
    (JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 2016)
  • Urinary ADAM12 and MMP-9/NGAL Complex Detect the Presence of Gastric Cancer
    (GASTROENTEROLOGY 2015)
  • C-reactive protein as an independent prognostic factor for metastatic gastric cancer
    (JOURNAL OF CLINICAL ONCOLOGY 2013)
ｍore...
Professional career (1)：
  • 医学博士
Committee career (2)：
  • 2021/07 - 現在 The Japanese Society of Gastroenterology Associate Editor, Journal of Gastroenterology
  • 2020/10 - 2021/12 Cancers Guest Editor
Awards (3)：
  • 2014/03 - The Surgical Research Council’s, 10th Annual Symposium in Cellular, Molecular, and Clinical Research in Surgery. The Winner Potential of urinary MMP-9/NGAL complex as a novel non-invasive biomarker for the early detection of gastric cancer
  • 2009/02 - 日本消化管学会 日本消化管学会学会賞最優秀賞(基礎部門) Suppression of proHB-EGF Carboxy-terminal Fragment Nuclear Translocation: A New Molecular Target Therapy for Gastric Cancer
  • 2008/12 - 名古屋市立大学医学会 名古屋市立大学医学会賞 HB-EGF-CTFを標的とした新規胃癌分子標的治療の可能性
Association Membership(s) (11)：
日本消化器癌発生学会:代議員 ,  日本癌治療学会 ,  日本癌学会 ,  American Society of Clinical Oncology(ASCO):Active Member ,  American Association for Cancer Research (AACR):Active member ,  日本消化管学会:認定医・専門医・代議員 ,  日本がん治療認定医機構:がん治療認定医 ,  日本臨床腫瘍学会:がん薬物療法専門医・指導医 ,  日本消化器内視鏡学会:専門医・指導医・学会評議員 ,  日本消化器病学会:専門医・指導医・学会評議員 ,  日本内科学会:認定医・専門医
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