Shimada Akira

シマダアキラ | Shimada Akira

Affiliation and department：
Job title： Professor

Research field (1)： Fetal medicine/Pediatrics

Research keywords (5)：感染免疫学 , 血液腫瘍学 , 小児科 , hematology/oncology. immunology/infectious disease , Pediatrics

Research theme for competitive and other funds (6)：

2020 - 2023 Molecular analysis of pediatric acute megakaryoblastic leukemia without Down syndrome
2015 - 2019 Molecular analysis of pediatric MDS/AML
2014 - 2015 Establishment of new system for genomic analysis for AML using by desk-top next generation sequencer
2012 - 2015 Development of novel molecular targeted therapy for juvenile myelomonocytic leukemia
2011 - 2013 Analysis of the resistant mechanism of AML stem cells for tyrosine kinase inhibitor in bone marrow microenvironment

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Papers (169)：

Genki Yamato, Yusuke Tsumura, Hideki Muramatsu, Akira Shimada, Takahiro Imaizumi, Hiroyuki Tsukagoshi, Taeko Kaburagi, Norio Shiba, Yoshiyuki Yamada, Takao Deguchi, et al. Cytokine profiling in 128 patients with transient abnormal myelopoiesis: a report from the JPLSG TAM-10 trial. Blood advances. 2024
Takahiro Aoki, Norio Shiba, Shinichi Tsujimoto, Genki Yamato, Yusuke Hara, Shota Kato, Kenichi Yoshida, Seishi Ogawa, Yasuhide Hayashi, Shotaro Iwamoto, et al. High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor. Pediatric blood & cancer. 2023. e30803
Yusuke Hara, Norio Shiba, Kenichi Yoshida, Genki Yamato, Taeko Kaburagi, Yuichi Shiraishi, Kentaro Ohki, Yusuke Shiozawa, Machiko Kawamura, Hirohide Kawasaki, et al. TP53 and RB1 alterations characterize poor prognostic subgroups in pediatric acute myeloid leukemia. Genes, chromosomes & cancer. 2023. 62. 7. 412-422
Genki Yamato, Tomoko Kawai, Norio Shiba, Junji Ikeda, Yusuke Hara, Kentaro Ohki, Shin-Ichi Tsujimoto, Taeko Kaburagi, Kenichi Yoshida, Yuichi Shiraishi, et al. Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia. Blood advances. 2022. 6. 11. 3207-3219
Takashi Taga, Shiro Tanaka, Daisuke Hasegawa, Kiminori Terui, Tsutomu Toki, Shotaro Iwamoto, Hidefumi Hiramatsu, Takako Miyamura, Yoshiko Hashii, Hiroshi Moritake, et al. Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome (Leukemia, (2021), 35, 9, (2508-2516), 10.1038/s41375-021-01157-w). Leukemia. 2021. 35. 12. 3622-3624

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MISC (94)：

Genki Yamato, Tomoko Kawai, Norio Shiba, Yusuke Hara, Kentaro Ohki, Taeko Kaburagi, Etsuko Ishikita, Hirohide Kawasaki, Kenichi Yoshida, Yuichi Shiraishi, et al. Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study. BLOOD. 2022. 140. 9134-9135
坪井伸成, 黒住和彦, 中野嘉子, 鷲尾佳奈, 嶋田明, 吉田朗彦, 河野隆志, 市村幸一, 柳井広之, 伊達勲. ARHGEF2-NTRK1融合遺伝子を有する高悪性度グリア神経細胞腫瘍の1例. Brain Tumor Pathology (Web). 2020. 37. Supplement
Takahiro Aoki, Hiroyuki Takahashi, Shiro Tanaka, Norio Shiba, Daiichiro Hasegawa, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, et al. Predisposition to Prolonged Neutropenia After Chemotherapy was Associated With Better Prognosis in Patients With Acute Myeloid Leukemia. PEDIATRIC BLOOD & CANCER. 2019. 66. S21-S21
Shimada Akira, Hasegawa Daiichiro, Imamura Toshihiko, Kaneda Makoto, Yagi Keiko, Takahashi Yoshihiro, Usami Ikuya, Suenobu Souichi, Nishimura Shinichiro, Hashii Keiko, et al. JACLS ALL02研究におけるAcute Mixed Leukemiaの遺伝子変異(Genetic Alterations in Acute Mixed Leukemia, Result of JACLS-ALL02 study). 日本小児血液・がん学会雑誌. 2019. 56. 4. 194-194
Hara Yusuke, Taki Tomohiko, Yamato Genki, Yoshida Kenichi, Shiba Norio, Kaburagi Taeko, Shiraishi Yuichi, Ohki Kentaro, Kawamura Machiko, Sotomatsu Manabu, et al. TP53遺伝子異常を伴う小児急性骨髄性白血病の臨床像と分子生物学異常の解析(Clinical and molecular characterization of pediatric acute myeloid leukemia with TP53 alterations). 日本小児血液・がん学会雑誌. 2019. 56. 4. 192-192

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Lectures and oral presentations (20)：

Panel-based NGS Identifies Prognostic and Actionable Genes in Childhood Acute Lymphoblastic Leukemia and Suits for Clinical Sequence.
(109th Annual Meeting of American Association of Cancer Research 2018)
Aberrant Methylation of Tumor Suppressor Genes in Pediatric Myelodysplastic Syndrome / Acute Myeloid Leukemia.
(109th Annual Meeting of American Association of Cancer Research 2018)
The challenge of risk-reclassification of Pediatric AML with FLT3 wild type - JPLSG AML05 study,
(Annual Meeting of International BFM study group 2016)
Poor prognosis with different induction rate was observed in children with acute myeloid leukemia and FLT3-ITD according to the ITD/WT allelic ratio: a result from the Japanese Pediatric Leukemia/Lymphoma Study Group
(米国血液学会 2013)
末梢血中WT1mRNA定量とFCM-MRDが再発の早期発見に有効であったAML-M7の一例
(日本小児血液がん学会 2013)

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Education (4)：

- 1999 Tottori University
- 1999 Tottori University Graduate School, Division of Medicine
- 1992 Tottori University Faculty of Medicine
- 1992 Tottori University Faculty of Medicine

Professional career (1)：

MD., PhD (Tottori University)

Work history (7)：

2021/06 - 現在 Jichi Medical University Department of Pediatrics Professor
2016/07 - 2021/05 Okayama University Department of Pediatric Hematology?Oncology Associate Professor
2012/04 - 2016/06 Okayama University Department of Pediatrics Assistant Professor
2009/10 - 2012/03 Nagoya University Department of Pediatrics
2007/08 - 2009/08 St.Jude Children's Research Hospital Department of Pharmacology Post.Doc fellow

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Awards (1)：

2011 - クレディセゾン賞

Association Membership(s) (11)：

日本臨床腫瘍学会 , 日本家族性腫瘍学会 , 日本人類遺伝学会 , 日本造血細胞移植学会 , 日本小児血液がん学会 , アメリカ癌学会 , 日本血液学会 , 米国血液学会 , 日本小児科学会 , American Association of Cancer Research , Japan Pediatric Society

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