Research theme for competitive and other funds (9)：
2022 - 2025 Structural optimization of vibsanins with skeletal diversity as protein kinase C activators
2019 - 2022 Structure–activity study and analysis of mechanism of action of vibsanins focused on pro-/anti-inflammatory switching
2017 - 2022 Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
2017 - 2019 非天然型希少リン酸化糖ライブラリの構築と生物活性評価
2015 - 2018 Development of C1 domain ligand with selectivity for non-PKC type C1 domain-containing proteins
2011 - 2016 Development and mechanistic analysis of new PKC ligands as anti-cancer agents
2011 - 2013 Development and mechanism of action of rare sugar derivatives with antiproliferative effect
2011 - 2012 Search for novel PKC ligands as therapeutic seeds for intractable diseases
2008 - 2009 Development of novel anticancer drug based on protein kinase C activator daphnoretin
Show all
Papers (55)：
Kota Seki, Tomoya Tanaka, Emiko Shimoda, Shinji Tanio, Ryo C. Yanagita, Tsugumi Miyazaki, Kento Tokumoto, Toshiaki Tazawa, Kumiko Osaki-Oka, Atsushi Ishihara. Identification of sesquiterpene aldehydes as volatile antifungal compounds in Phaeolepiota aurea culture filtrate. Bioscience, Biotechnology, and Biochemistry. 2024. 88. 12. 1395-1402
Ryo C. Yanagita, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie. Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(-)-carvone-based core. Bioscience, Biotechnology, and Biochemistry. 2024. 88. 9. 992-998
Yusuke Hanaki, Rintaro Abe, Yasunori Sugiyama, Yasumasa Hara, Ryo C. Yanagita. A new labdane-type diterpenoid from leaves of Vitex rotundifolia. Results in Chemistry. 2024. 101512-101512
Jumpei Maki, Yusuke Hanaki, Ryo C Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie. Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 12. 1453-1461
Yusuke Hanaki, Nichika Iwase, Yasunori Sugiyama, Sena Miyoshi, Ryo C. Yanagita. Cell Morphology-Based Screening Identified Vitetrifolin D from Vitex rotundifolia as an Inhibitor of Phorbol Ester-Induced Downregulation of E-Cadherin in HHUA Endometrial Cells. BPB Reports. 2023. 6. 3. 103-107
眞木準平, 花木祐輔, 柳田亮, 菊森将之, 鷲崎彩夏, 塚野千尋, 明里宏文, 入江一浩. LRA activity and pharmacokinetics of phosphate of 10-Me-Aplog-1, a simplified aplysiatoxin analog. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
奥田創元, 塚野千尋, 柳田亮, 入江一浩. Synthesis and PKC binding of a cis-pyran type-simplified analogue of alotaketals. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
眞木準平, 押村亜沙美, 塚野千尋, 柳田亮, 入江一浩. Synthesis and PKC binding of a trans-decalin type-simplified analogue of alotaketals. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
眞木準平, 押村亜沙美, 塚野千尋, 柳田亮, 齋藤裕, 齋藤裕, 榊原康文, 入江一浩. Design, synthesis and PKC surrogate binding of the simplified analogues of alotaketals. 複素環化学討論会講演要旨集. 2022. 51st
Kawamura T, Matsubara K, Otaka H, Tashiro E, Shindo K, Yanagita R, Irie K, Imoto M. Erratum: Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP (Bioorganic and Medicinal Chemistry (2011) 19 (4377-4385)). Bioorganic and Medicinal Chemistry. 2012. 20. 7
