Okajima Tetsuya

オカジマテツヤ | Okajima Tetsuya

Affiliation and department：
Job title： Professor
Other affiliations (4)：

Nagoya University Graduate School of Medicine Professor
Nagoya University Institute of Liberal Arts and Sciences, Headquarters Part-time faculty member
Nagoya University Graduate School of Medicine
Nagoya University

Homepage URL (1)： http://www.med.nagoya-u.ac.jp/seika2/home.html

Research keywords (1)： Protein domain-specific glycans

Research theme for competitive and other funds (14)：

2022 - 2025 糖転移酵素群によるNOTCHタンパク質の分泌・分解の仕分け機構の解明
2020 - 2023 加齢に伴う運動能力低下におけるNotch1上の細胞外O-GlcNAc機能の解明
2019 - 2022 Regulation of Notch signaling in muscle satellite cells by O-glucose glycosylation
2018 - 2019 Notch受容体糖鎖コードの時空間情報解読に向けたin vivoレポーターシステムの構築
2018 - 2019 糖転移酵素EOGTによるNotchシグナルと血管形成の制御機構の解明

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Papers (94)：

Yohei Tsukamoto, Mitsutaka Ogawa, Kentarou Yogi, Yuko Tashima, Hideyuki Takeuchi, Tetsuya Okajima. Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1. Glycobiology. 2022. 32. 7. 616-628
Wang Weiwei, Okajima Tetsuya, Takeuchi Hideyuki. Significant Roles of Notch O-Glycosylation in Cancer. MOLECULES. 2022. 27. 6
Robiul Bhuiyan, Yesmin Farhana, Kondo Yuji, Ohkawa Yuki, Ohmi Yuhsuke, Zhang Pu, Okajima Tetsuya, Furukawa Keiko, Furukawa Koichi. Unique effects of expression of asialo-series ganglioside GD1alpha in human cancer cell lines. CANCER SCIENCE. 2022. 113. 379-379
Farhana Yesmin, Bhuiyan Robiul H, Ohmi Yuhsuke, Horiuchi Momoka, Okajima Tetsuya, Yamamoto Satoko, Furukawa Keiko, Furukawa Koichi. Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. CANCER SCIENCE. 2022. 113. 1104-1104
Haltiwanger RS, Wells L, Freeze HH, Jafar-Nejad H, Okajima T, Stanley P, Varki A, Cummings RD, Esko JD, Stanley P, et al. Other Classes of Eukaryotic Glycans. 2022

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Books (12)：

Glycoscience: Biology and Medicine, Editors: Taniguchi N. et al. Extracellular O-GlcNAcylation
Springer 2015
Handbook of Glycosyltransferases and Related Gene, Editors: Taniguchi N. et al. ST3 β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6)
Springer 2014
Handbook of Glycosyltransferases and Related Gene, Editors: Taniguchi N. et al. ST6 N-acetylgalactosaminide α-2,6-sialyltransferase 5,6 (ST6GALNAC5,6)
Springer 2014
第三の生命鎖糖鎖の機能と疾患編集門松健治ら新たに同定されたO-GlcNAc型ドメイン特異糖鎖と生物学的役割
羊土社 2013
Experimental Glycoscience, Editors: Taniguchi, N. et al. Glycosyltransferases involved in O-fucose glycan synthesis.
Elsevier 2008

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Lectures and oral presentations (11)：

Structure and function of extracellular O-GlcNAc
(10th ACGG Conference 2018)
O-グルコース糖鎖のキシロシル化の Notch シグナルにおける役割の解析
(第91回日本生化学会大会 2018)
Notch受容体糖鎖情報トラジェクトリーの理解に向けた細胞外O-GlcNAc修飾の構造機能解析
(第91回日本生化学会大会 2018)
哺乳動物Notch1の上皮成長因子様リピートを修飾するO-GlcNAc糖鎖の構造多様性
(第37回日本糖質学会年会 2018)
Roles of N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT)-catalyzed Notch1 O-GlcNAcylation and Notch signaling
(2018)

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Work history (14)：

2018/04/01 - 現在 Nagoya University Institute of Liberal Arts and Sciences
2015/11/01 - 現在名古屋大学大学院医学系研究科教授
2015/11/01 - 現在 Nagoya University Graduate School of Medicine Program in Integrated Medicine Biological Chemistry Professor
2015/11/01 - 現在 Nagoya University Graduate School of Medicine Center for Neural Disease and Cancer Division Professor
2016/10/01 - 2019/09/30 Nagoya University Institute for Advanced Research

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Awards (4)：

Association Membership(s) (3)：

日本分子生物学会 , 日本糖質学会 , 日本生化学会

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