Okada Atsushi

2022 - 2025 尿路結石の組成・構造の高分解イメージング: 結石成長を加速する結晶相転移現象解明

2021 - 2024 抗酸化遺伝子Nntによる尿路結石抑制機構を用いた予防治療への検討

2020 - 2023 分子生物学・鉱物学・隕石学の融合による尿路結石の形成機序解明と新規予防法の創設

2020 - 2023 メタボリックシンドロームにおける細胞接着分子の発現と腎結石促進機序の解明

2020 - 2023 尿路結石マトリックス蛋白オステオポンチンを標的としたマクロファージ貪食機序の解明

2019 - 2023 Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms

2019 - 2022 酸化ストレス活性化転写因子Nrf2をターゲットとした尿路結石症予防法の開発

2019 - 2022 酸素ナノバブル水による腎結石形成の抑制機序の解明と予防法の開発

2018 - 2022 Development of medication for urolithiasis via selective autophagy

2018 - 2022 Development of a new preventive drug for urinary calculus focusing on the anti-metabolic syndrome effect of beige cells

2018 - 2022 Development of urinary stone prevention method targeting mitochondrial cyclophilin D

2018 - 2022 Elucidation of the suppression mechanism and application to preventive treatment by the novel related gene Nnt of urolithiasis

2018 - 2021 Establishment of a novel biomarker for renal calculi

2017 - 2020 Elucidation of the mechanism of the kidney stone formation related by kidney differentiation inducing factor and its application to treatment

2017 - 2020 Elucidation and clinical application of a novel method for preventing urolithiasis focusing on the antioxidant effect of estrogen

2016 - 2019 Development of the biomaker of kidney stone formation

2016 - 2019 Omics analysis of macrophage-related molecules for urolithiasis dissolution therapy

2016 - 2019 Elucidation of suppression mechanism for kidney stone formation by oxygen nano bubble water and application to the prevention method

2016 - 2019 Identification of factors involved in formation and elimination of urinary stones and development of new risk diagnosis and prevention methods

2016 - 2019 Basic research for urolithiasis preventive drug development focused on the function of polymerized OPN and autophagy

2015 - 2018 Elucidation of the mechanism of urinary stone formation in metabolic syndrome and its application to molecular target treatment

2015 - 2018 A comprehensive study of the establishment of urolithiasis prophylaxis from both genetic factors and environmental factors

2015 - 2018 Elucidation of the pathology of mitochondrial injury during urinary calculi formation and development of prevention.

2015 - 2018 The role of the cleaved osteopintin in stone formation

2014 - 2017 Establishment of diagnostic markers for recuccent stone disease by genome-wide associated analysis.

2013 - 2016 Investigation of the effect of anti-osteopontin antibody on renal crystal formation

2013 - 2016 Effects of atherosclerosis-related factors on renal crystal formation in a mouse model of metabolic syndrome

2013 - 2016 Functional analysis of urinary stone formation to target the mitochondrial membrane and its application to prophylaxis

2013 - 2016 Elucidation of the inhibiting mechanism of the urolithiasis using the antioxidant effect of the female hormone and the clinical application

2013 - 2016 Prevention of urolithiasis using anti-NF-kB drugs

2013 - 2016 Establishment of the new concept, 'spontaneous elimination of kidney stones' and application to development of the dissolution therapy

2012 - 2015 A new treatment agent determining renal calcium crystallization through cyclophilin D activation.

2012 - 2015 Biomolecular mechanism of urinary stone formation, and development of medicine

2012 - 2015 The functional analysis of kidney stone-phagocytosis activity by the macrophages and the application to dissolution therapy.

2012 - 2015 The antiapoptosis effect of the heat receptor (TRPV1)-promoter for the prevention of kidney stone.

2011 - 2015 Integrated elucidation of the urinary stone formation mechanism considered from heredity and environment factors, and development of the new therapeutic medicines

2011 - 2013 Cross sectional study from gene and environmental factor towards

2011 - 2013 Development of prophylaxis by the elucidation of the pathogenesis in the initial urinary stone formation

2010 - 2012 Anti-NF-kB reagents for prevention of urinary stone

2009 - 2011 The role of macrophages for prevention of kidney stone formation

2009 - 2010 The elucidation of the kidney stone formation mechanism from a microstructural change and the oxidative stress of the renal tubular epithelial cell.

2008 - 2010 Research for establishment of prevention for urolithiasis by considering metabolic syndrome

2008 - 2010 Evaluation of urinary stone formation with respect to oxidative stress and analysis of osteopontin function using transgenic mice.

2008 - 2009 ゲノム情報を用いた尿路結石形成機序の解明と遺伝子診断・予防法の開発

2007 - 2008 Analysis of the functional domains of osteopontin (OPN) on renal stone formation using OPN-transgenic and OPN-knockout mice

2007 - 2008 腎結石形成・消失現象に関わる遺伝子群の同定とマクロファージ機能の解明