Rchr
J-GLOBAL ID：201001083137128545   Update date: Feb. 01, 2024

Uchida Yasuo

ウチダ ヤスオ | Uchida Yasuo
Affiliation and department：
Hiroshima University Graduate School of Biomedical and Health Sciences

About Hiroshima University Graduate School of Biomedical and Health Sciences


Job title： Professor
Homepage URL  (2)： https://www.hiroshima-u.ac.jp/pharm/research/lab/Pharmaceutics_and_Therapeutics ,  https://www.hiroshima-u.ac.jp/en/pharm/research/lab/Pharmaceutics_and_Therapeutics
Research field  (5)： Internal medicine - General ,  Biomedical engineering ,  Nanobioscience ,  Pharmacology ,  Clinical pharmacy
Research keywords  (16)： バリア制御学 ,  脳型超越分子システム ,  ECM定量プロテオミクス ,  パラフィン切片プロテオタイピング ,  バリアシステム生物学 ,  中枢関門を介した薬物・内因性物質の輸送 ,  血液脳脊髄液関門 ,  血液脊髄関門 ,  血液クモ膜関門 ,  Pressure Cycling Technology (PCT) ,  SWATH(次世代型定量プロテオミクス) ,  Quantitative Absolute Proteomics ,  Transporters ,  Blood-brain barrier ,  ADME ,  Pharmacoproteomics
Research theme for competitive and other funds  (31)：
  • 2022 - 2026 Molecular basis of blood biomarkers inducing fundamental innovation in glioblastoma medicine
  • 2023 - 2026 血液脳関門・クモ膜関門・脳脊髄液関門による脳内薬物動態の時・空間的制御機構の解明
  • 2023 - 2026 血液脳関門の輸送機構では説明できない中枢薬物動態の機構解明
  • 2022 - 2024 高分子医薬の脳へのデリバリーの突破口を拓く脳型ナノ粒子のボトムアップ構築
  • 2022 - 2024 ヒト脳内金属動態における血液脳関門・血液クモ膜関門・血液脳脊髄液関門の役割の解明
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Papers (64)：
  • Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, et al. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. Journal of Medicinal Chemistry. 2023. 66. 8. 5453-5464
  • Yi Wang, Maki Sakaguchi, Hemragul Sabit, Sho Tamai, Toshiya Ichinose, Shingo Tanaka, Masashi Kinoshita, Yasuo Uchida, Sumio Ohtsuki, Mitsutoshi Nakada. COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion. Journal of Neurosurgery. 2023. 138. 3. 639-648
  • Hiromu Ishiguro, Tadahaya Mizuno, Yasuo Uchida, Risa Sato, Hayate Sasaki, Shumpei Nemoto, Tetsuya Terasaki, Hiroyuki Kusuhara. Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method. NAR Genomics and Bioinformatics. 2023. 5. 1
  • Marie-Pierre Dehouck, Masanori Tachikawa, Yutaro Hoshi, Kotaro Omori, Claude-Alain Maurage, Guillaume Strecker, Lucie Dehouck, Marie-Christine Boucau, Yasuo Uchida, Fabien Gosselet, et al. Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells. Cells. 2022. 11. 24. 3963-3963
  • Takumi Handa, Hayate Sasaki, Masaki Takao, Mitsutoshi Tano, Yasuo Uchida. Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method. Fluids and Barriers of the CNS. 2022. 19. 1
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MISC (30)：
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Books (5)：
  • Blood-arachnoid barrier as a dynamic physiological and pharmacological interface between cerebrospinal fluid and blood
    2022
  • Recent progress in blood-brain barrier and blood-CSF barrier transport research: Pharmaceutical relevance for drug delivery to the brain. IN Drug Delivery to the Brain - Physiological Concepts, Methodologies and Approaches, Margareta Hammarlund-Udenaes, E
    Springer, pp 23-62 2014
  • Chapter 10 Pharmacoproteomics. IN Essential Manual for Pharmaceutical Experiment, Y Watanabe, Y Deguchi and K Ito (Ed.)
    Nankodo Co., Ltd. Tokyo, pp312-324 2014
  • Blood-brain barrier (BBB) pharmacoproteomics: a new research field opened up by quantitative targeted absolute proteomics (QTAP). IN Drug Delivery to the Brain - Physiological Concepts, Methodologies and Approaches, Margareta Hammarlund-Udenaes, Elizabeth
    Springer, pp 63-100 2014
  • The role of drug transporters at blood-brain barrier. IN The World of Transportsome -From Headstream of Membrane Transport Research to the Future-, Y Kanai, H Takeshima, Y Mori and Y Kubo (Ed.)
    Kyoto Hirokawa Publishing Inc. Tokyo, pp282-290 2011
Lectures and oral presentations  (43)：
  • 日本が誇るブレインバンクのヒト脳組織を活用した病態プロテオミクス研究
    (日本薬学会第144年会 2024)
  • Next Generation Quantitative Proteomicsによって拓かれる中枢関門研究の新展開
    (第149 回 日本薬学会中四国支部例会 2024)
  • 膜タンパク質定量プロテオミクスによる中枢組織の輸送分子機構の解明
    (日本膜学会「第45年会」・「膜シンポジウム2023」合同大会 2023)
  • くすりは飲んだ後、体の中をどう動いていく?くすりの生体内運命と最先端の新薬開発研究
    (三原高等学校学問体験講座 2023)
  • Next generation quantitative proteomics opens up the new fields of central nervous system barrier studies
    (Korean Society of Applied Pharmacology (KSAP) annual meeting 2023 2023)
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Education (2)：
  • - 2010 Tohoku University Graduate School, Division of Pharmaceutical Sciences 医療薬科学専攻
  • - 2006 Tohoku University Faculty of Pharmaceutical Science 総合薬学科
Professional career (1)：
  • Ph.D. (Tohoku University)
Work history (7)：
  • 2023/04 - 現在 Graduate School of Biomedical and Health Sciences, Hiroshima University Professor
  • 2023/03 - 2023/03 Graduate School of Pharmaceutical Sciences Associate Professor
  • 2018/09 - 2023/02 Graduate School of Pharmaceutical Sciences lecturer
  • 2012/02 - 2018/08 Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University Assistant Professor
  • 2014/04 - 2016/03 Institute of Molecular Systems Biology, ETH Zurich (Prof Ruedi Aebersold group) (JSPS postdoctoral fellow for research abroad) JSPS postdoctoral fellow for research abroad Visiting Scientist
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Committee career (9)：
  • 2008/04 - 現在 トランスポーター研究会 幹事
  • - 現在 日本薬剤学会 代議員
  • - 現在 Journal of Neurochemistry Editor
  • - 現在 Molecular Pharmaceutics Editorial Advisory Board
  • - 現在 Journal of Pharmaceutical Sciences Editorial Advisory Board
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Awards (17)：
  • 2023/04 - The Young Scientists’ Award, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
  • 2022/04 - CREST細胞外微粒子Young Innovator Award
  • 2020/11 - Journal of Pharmaceutical Sciences Top reviewer award
  • 2020/03 - 日本薬学会 2020年度日本薬学会奨励賞 「定量プロテオミクスに基づく血液脳関門の輸送機能および病態変動機構の解明」
  • 2018/07 - 平成30年度東北大学大学院薬学研究科長賞
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Association Membership(s) (9)：
Japan Transporter Research Association ,  The Pharmaceutical Society of Japan ,  The Academy of Pharmaceutical Science and Technology, Japan ,  The Japanese Society for the Study of Xenobiotics ,  Human Proteome Organization ,  International Society for the Study of Xenobiotics ,  American Association of Pharmaceutical Scientists ,  International Brain Barriers Society ,  International Society for Neurochemistry
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