Rchr
J-GLOBAL ID：201001091345419220
Update date: Sep. 10, 2024
Takata Fuyuko
タカタ フユコ | Takata Fuyuko
Affiliation and department：
Research field (3)：
Pharmaceuticals - health and biochemistry
, Pharmacology
, Clinical pharmacy
Research keywords (8)：
diabetes mellitus
, obesity
, brain inflammation
, posttraumatic brain epilepsy
, パーキンソン病
, traumatic brain injury
, blood brain barrier
, brain pericyte
Research theme for competitive and other funds (14)：
- 2023 - 2026 Chronotherapeutic strategy for Parkinson's disease by intranasal administration of human iPS-derived brain pericytes
- 2022 - 2026 Novel Therapeutic Strategies through Pericyte Modulation and Apoptosis Prevention in Acute Encephalopathy
- 2021 - 2024 病変型脳ペリサイトのαシヌクレイン処理能障害による頭部外傷後のパーキンソン病発症
- 2019 - 2022 Involvement of activated brain pericytes induced by inflammatory bowel disease in the increased aggregation of alpha-synuclein in the brain.
- 2018 - 2021 The role of pericytes in the development of epileptogenesis after traumatic brain injury
- 2016 - 2019 Involvement of brain pericytes in alpha-synuclein-induced dysfunction of the blood-brain barrier and dopaminergic neurons
- 2016 - 2019 The brain pericytes-induced blood-brain barrier dysfunction and the central adverse effects in the chronic obstructive pulmonary disease
- 2014 - 2018 A key role of the brain pericytes in the induction and development of brain inflammation under the pathophysiological conditions of obesity-associated diabetes.
- 2013 - 2016 Adverse effects of varenicline on the neurovascular unit
- 2011 - 2013 Involvement of pericytes-derived cyclophilin A in the development of insulin resistanse in the brain
- 2010 - 2012 Identification of predictive biomarkers for pathological alterations of BBBfunctions.
- 2009 - 2010 Involvement of brain pericytes in the development of obesity
- 2006 - 2007 高脂血症の血液脳関門病態化における脳ペリサイトの役割
- 2005 - 2006 後期糖化反応生成物特異的受容体を介した血液脳関門病態の解明
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Papers (58)：
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Lihong Cheng, Mitsuru Tanaka, Atsuko Yoshino, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu, Toshiro Matsui. A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration. Scientific Reports. 2023. 13. 16908
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Yusuke Watanabe, Gaku Yamanaka, Shinichiro Morichi, Kanako Hayashi, Shinji Suzuki, Mika Takeshita, Natsumi Morishita, Yu Ishida, Shingo Oana, Fuyuko Takata, et al. Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome. Brain & development. 2023
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Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yuki Goto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains. Biochemical and biophysical research communications. 2023. 645. 154-163
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Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice. PloS one. 2023. 18. 2. e0281946
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αシヌクレインによる血液脳関門障害. 2022. 40. 12. 1599-1601
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MISC (4)：
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高橋諒, 森地振一郎, 渡邊由祐, 林佳奈子, 高松朋子, 鈴木慎二, 石田悠, 小穴信吾, 高田芙友子, 山中岳. Investigation of serum pericyte markers in childhood refractory epilepsy. てんかん研究. 2023. 41. 2. 394-394
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Kousuke Matsumoto, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Natsuko Ichiki, Sayaka Tao, Haruki Miyaji, Tsuyoshi Nishioku, Hideki Shuto, Atsushi Yamauchi, et al. Reactive oxygen species (ROS)-mediated regulation of MMP-9 expression in the brain pericytes. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 189P-189P
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Koji Sueishi, Kayoko Fujishita, Kaoru Nasu-Tada, Fuyuko Takata, Yasufumi Kataoka, Schuichi Koizumi. Release of matrix metalloproteinase-9 from pericytes via ATP/P2 receptor-mediated signals. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2007. 103. 192P-192P
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小泉修一, 藤下加代子, 末石浩二, 末石浩二, 道具伸也, 高田芙友子, DELI Maria A., DELI Maria A., 井上和秀, 片岡泰文, et al. 血液脳関門(BBB)を標的とした創薬 ATP. 生体機能と創薬シンポジウム. 2006. 2006
Books (2)：
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Inflammatory Mediators Released by Brain Pericytes as Sensors and Effectors in Blood-Brain Barrier Dysfunction
Humana Press 2021
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Biochemical Approaches for Glutamatergic Neurotransmission Measurement of Astrocytic Glutamate Release Using Genetically Encoded Probe Combined with TIRF Microscopy
Humana Press 2018 ISBN:9781493972272
Lectures and oral presentations (188)：
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炎症性腸疾患モデルマウスにおける脳内α-シヌクレイン単量体の増加
(NEURO2024 2024)
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マンナン感受性輸送担体を介した単量体αシヌクレインの血液脳関門透過
(NEURO2024 2024)
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A vascular endothelial cell-derived factor enhances the ability of iPSC-derived brain pericytes to degrade α-Synuclein
(ISSCR2024 2024)
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Noggin投与によるBMP4阻害は頭部外傷後の血液脳関門障害を改善する
(日本薬学会第144年会 2024)
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脳血管内皮細胞のバリア機能に対する BMP-9 の影響
(日本薬学会第144年会 2024)
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Education (1)：
- 2004 - 2007 Fukuoka University Graduate School, Division of Pharmaceutical Sciences
Professional career (1)：
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