Itohara Shigeyoshi

Affiliation and department：
Other affiliations (8)：

日本神経科学会
日本分子生物学会
日本実験動物学会
日本獣医学会
日本神経化学会

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Homepage URL (1)： http://bgshige.brain.riken.jp/index.htm

Research field (3)： Laboratory animal science , Neuroanatomy and physiology , Neuroscience - general

Research keywords (32)：包括脳ネットワーク , 統合脳・分子脳科学 , Gene targeting , 樹状突起 , 癌の増殖と転移 , Secretion , Amyloid precursor protein , 小脳深部核 , netrin-G2 , netrin-G1 , プロテア-ゼ , 分泌酵素 , 膜タンパク質 , 小脳 , アミロイド蛋白質 , Secretase , 軸索 , 運動学習 , ゲラチナ-ゼ , 神経回路 , Mutant mouse , Gelatinase A , 扁桃体 , シナプス , ネトリン , 可塑性 , 瞬目条件反射学習 , 遺伝子 , Alzheimer's disease , Matrix Metalloproteinase 2 , ニューロン , ノックアウトマウス

Research theme for competitive and other funds (15)：

2015 - 2019 視床皮質回路依存的ADHDモデルマウスの樹立
2008 - 2010 Netrin-G/NGL interaction for integrating neuronal information
2008 - 2009 遅延型瞬目条件反射学習の二段階学習機構の解析
2006 - 2007 瞬目条件反射学習における小脳深部核の2峰性遺伝子転写制御の解析
2004 - 2006 Basic Research on Effectiveness of Vibratory Microinjection Method

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Papers (257)：

Zhang Q, Kobayashi Y, Goto H, Itohara S. An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents. 2018. doi: 10.3791/57895.
Masuda A, Kobayashi Y, Itohara S. Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage. J. Vis. Exp. 2018. doi: 10.3791/58009.
Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, et al. Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Communications Biology. 2018. doi: 10.1038/s42003-018-0099-2
Kato TM, Kubota-Sakashita M, Fujimori-Tonou N, Saitow F, Fuke S, Masuda A, Itohara S, Suzuki H, Kato T. Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder. Molecular Psychiatry. 2018
Kuroki S, Yoshida T, Tsutsui H, Iwama M, Ando R, Michikawa T, Miyawaki A, Ohshima T, Itohara S. Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex. Cell Reports. 2018. 22. 11. 2873-2885

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MISC (15)：

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Patents (4)：

Detecting aberrant animal-derived prion gene, by introducing prion gene of an animal into a mouse to produce a prion gene modified mouse and determining whether the prion gene modified mouse exhibits a heart anomaly
Membrane bound type netrin, comprises hydrophobic region which can be combined to cell membrane through glycosylphosphatidylinositol at C-terminal
Novel non-human animal e.g. mouse model for osteoporosis and/or craniosynostosis having defective matrix metalloprotease-2 gene, useful for evaluating effect of test substance as osteoporosis and/or craniosynostosis therapeutic agent
Agent useful for controlling axon extension for treating nerve damage disease e.g. spinal injury, comprises agent e.g. DNA or double-stranded RNA capable of stimulating or suppressing function of alpha-chimerin

Professional career (1)：

Ph.D. (University of Tokyo)

Work history (9)：

2018/04 - 現在 RIKEN Center for Brain Science Laboratory for Behavioral Genetics Team Leader
2007/04 - 2018/03 Department of Life Science and Medical Bio-Science, Waseda University Visiting Professor
1997/12 - 2018/03 理化学研究所行動遺伝学技術開発チームチームリーダー(研究職)
2007/04 - 2017/03 Graduate School of Agricultural and Life Sciences, University of Tokyo Adjunctive Professor
1993/04 - 1997/11 Kyoto University Institute for Virus Research

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