Sugano Eriko

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/70375210

Research field (1)： Ophthalmology

Research keywords (17)：人工網膜チップ , チャネルロドプシン-2 , サル , 神経節細胞 , 一次視覚野 , 人工視覚 , 三次元積層化技術 , 人工網膜 , 網膜変性 , ウサギ , アポトーシス , 網膜色素上皮細胞 , 加齢 , ミトコンドリア , 酸化ストレス , 遺伝子 , 網膜

Research theme for competitive and other funds (29)：

2022 - 2026 オプトジェネティクスと工学技術の融合による視覚野刺激型視覚再建デバイスの開発
2022 - 2025 バイオインフォマティクスによるAAVベクター改変と低侵襲遺伝子導入技術の開発
2021 - 2025 Protection of retinal degenerations by controling neurotrophins secreation via optogenetic technologies
2021 - 2024 人と同じ視野角と情報処理機能を有する極低侵襲ピクセル分散型完全埋植人工網膜の開発
2021 - 2024 視覚再生網膜のレチナール供給機構の解明と視機能の増強

2019 - 2023 Visual properties in rats transuduced newly developed step function opsin

2019 - 2022 Opt-ECoG system development for manipulating the cortical top-down circuit of self-agency

2019 - 2022 Design of new optogenetic genes by a bioinformatic approach

2017 - 2022 Model construction and theorization of intercell interactions

2018 - 2021 To elucidate an enhanced function of Channelrhodopsin and its mechanism

2018 - 2021 Alterations in synaptic stability and trials of their adjustment in autism model marmosets

2018 - 2021 Development of Fully Implantable and Minimally Invasive Flexible Retina Prosthesis for Reconstruction of Wide Field of Vision

2016 - 2019 Optogenetic vector for inhibition of photoreceptor degeneration

2016 - 2019 Regeneration of color vision in blind rats using channelrhodopsin genes having different wavelength properties

2016 - 2018 Changes of function in the visual cortex after blindness and regeneration

2015 - 2018 Development of fully-implantable retinal prosthesis system realizing the same visual information processing as human vision

2014 - 2016 Development of the retinal ON-OFF responses using archeal rhodopsins

2013 - 2016 Control of ganglion cells for producing the On- and Off response using optogenetic tools.

2012 - 2015 Evaluation of restored visual function by using chronically implantable ECoG electrode array.

2010 - 2013 チャネルロドプシン発現神経節細胞の形態学的分類による視機能シミュレーション

2011 - 2012 Replacement Gene Therapy for photoreceptor survival.

2011 - 2012 Artificial sight produced by transducing genes into primary visual cortex

2009 - 2011 Establishment of a method for restoring vision using light-gated ion channels and the promotion of optogenetics

2009 - 2009 Restore vision by transgene of Channelrhodopsin2 on ON-type bipolar cells in genetically blind rat.

2007 - 2008 光感受性遺伝子を用いた新しい神経節細胞の機能評価法の確立

2007 - 2008 Study for the treatment with ALDH2 against age-related retinal degeneration.

2005 - 2007 Basic studies of three dimensionally stacked retinal prosthesis toward for clinical trials

2005 - 2006 サルを用いた人工視覚の行動学的解析

2005 - 2006 網膜色素上皮細胞のアポトーシスにおけるBitlシグナルの解明

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Papers (99)：

Yusaku Chukai, Toru Sudo, Tomokazu Fukuda, Hiroshi Tomita, Eriko Sugano, Taku Ozaki. Proteolysis of mitochondrial calpain-13 in cerebral ischemia-reperfusion injury. Biochemistry and biophysics reports. 2024. 39. 101768-101768
Lanlan Bai, Tetsuya Tani, Takeshi Kobayashi, Ryotaro Nouda, Yuta Kanai, Yusuke Sano, Kazutoshi Takami, Hiroshi Tomita, Eriko Sugano, Taku Ozaki, et al. Egyptian Rousettus bat, immortalized cells, cell cycle regulator, TERT, SV40 large T antigen. FEBS Open Bio. 2024
Lanlan Bai, Tetsuya Tani, Takeshi Kobayashi, Ryotaro Nouda, Yuta Kanai, Yusuke Sano, Kazutoshi Takami, Hiroshi Tomita, Eriko Sugano, Taku Ozaki, et al. Establishment of immortalized Egyptian Rousettus bat cell lines. FEBS Open Bio. 2024
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki. Role of calpain-5 in cerebral ischemia and reperfusion injury. Biochimica et biophysica acta. General subjects. 2024. 1868. 1. 130506-130506
Aya Sekine, Genta Yasunaga, Soichiro Kumamoto, So Fujibayashi, Izzah Munirah, Lanlan Bai, Tetsuya Tani, Eriko Sugano, Hiroshi Tomita, Taku Ozaki, et al. Characterization of Common Minke Whale (Balaenoptera Acutorostrata) Cell Lines Immortalized with the Expression of Cell Cycle Regulators. Advanced Biology. 2023

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MISC (89)：

野口潤, 渡辺恵, 三嶋晶, 中垣慶子, 磯田李紗, 境和久, 菅野江里子, 冨田浩史, 渡我部昭哉, 山森哲雄, et al. マーモセット自閉症モデル大脳皮質樹状突起スパインのin vivo2光子顕微鏡観察. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
Eriko Sugano, Kitako Tabata, Yuko Sakajiri, Yoshito Watanabe, Makoto Tamai, Hiroshi Tomita. Protein structural prediction of modified Volvox channelrhodopsin-1 and the verification by amino acid sequence. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2018. 59. 9
Yoshihiro Takai, Daisuke Mori, Akihisa Sugai, Azusa Sema, Yoko Mitsuguchi, Eriko Sugano, Hiroshi Tomita, Takahiro Kurose, Yoichi Honma. Comparison of neuroprotective effects of oil- and water-soluble fractions of sea buckthorn juice against light-induced retinal degeneration in rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2018. 59. 9
Hiroshi Tomita, Eriko Sugano, Kitako Tabata, Toshiyuki Yamane, Eiichiro Nagasaka, Hidetaka Kudo, Daigo Yoshikawa, Masao Yoshikawa, Fumio Nakazawa, Naomi Kitaura, et al. Induction of local photoreceptor degeneration by a subretinal injection of N-Methyl-N-nitrosourea in rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2018. 59. 9
澁谷仁寿, 澁谷仁寿, 渡邉京祐, 奈良篤樹, 田端希多子, 佐藤美穂, 前野哲輝, 菅野江里子, 田村勝, 冨田浩史, et al. Mitf変異体マウスを用いた眼球におけるメラノサイトの遺伝学的機能解析. 日本遺伝学会大会プログラム・予稿集. 2018. 90th

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Professional career (1)：

博士(生命科学) (東北大学)

Work history (6)：

2016/04 - 現在 Iwate University Faculty of Engineering, Department of Chemistry and Bioengineering
2012/04 - 2016/03 Iwate University Faculty of Engineering, Department of Chemistry and Bioengineering
2007/09 - 2012/03 東北大学国際高等融合領域研究所助教
2007/04 - 2007/08 東北大学先進医工学研究機助教
2006/04 - Tohoku University Biomedical Engineering Research Organization

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