Yagi Maho

ヤギマホ | Yagi Maho

Affiliation and department：
Job title： Assistant Professor
Other affiliations (1)：

National Institutes of Natural Sciences Exploratory Research Center on Life and Living Systems (ExCELLS) Associate Professor (adjunct)

Homepage URL (2)： https://nrid.nii.ac.jp/ja/nrid/1000040608999/ , https://nrid.nii.ac.jp/en/nrid/1000040608999/

Research field (3)： Pharmaceuticals - analytical and physicochemistry , Structural biochemistry , Biophysics

Research keywords (7)： amyloid fibril , ganglioside , Neurodegenerative disease , glycosphingolipid , NMR , amyloid β , Alzheimer's disease

Research theme for competitive and other funds (18)：

2022 - 2025 アッセンブリー補助によるタンパク質の配置制御
2022 - 2024 クマムシ由来非ドメインタンパク質の分子ネットワークの実体解明
2019 - 2024 Protein Encapsulation by Synthetic Cages for Functional Control and Structure Determi nation
2019 - 2023 Elucidation of the functional mechanisms associated with structural dynamics of antibodies by integration of cutting-edge measurement approaches
2018 - 2023 新世代中性子構造生物学の開拓

2019 - 2022 タンパク質分子を取り巻く環境を考慮した構造解析によるアミロイド形成機構の解明

2018 - 2019 細胞再現系での蛋白質の構造・ダイナミクスの解明

2017 - 2019 Understanding of polymerization mechanism based on three-dimensional structural information of extension end of amyloid fibril toward to drug discovery

2015 - 2019 Elucidation of the proteasome formation mechanisms through multilateral structural biology approach toward drug discovery

2017 - 2019 アミロイド線維の伸長末端の3次元構造情報に基づく重合機構の理解および創薬展開

2013 - 2018 Exploration of micro-macro relationships in dynamic ordering of biomolecular systems and their underlying design principles

2015 - 2017 Structural characterization of conformational transition of amyloid beta peptide promoted on ganglioside clusters

2015 - 2017 ガングリオシド糖脂質クラスター上におけるアミロイドβの構造転換の精密解析

2012 - 2015 Elucidation of structural basis of glycoconjugate functions and its application for molecular design toward developing drugs targeting the carbohydrate recognition systems

2012 - 2014 Identification and structural-functional analysis of shuttle-type proteasome activator exhibiting molecular chaperone activity

2011 - 2012 Characterization of conformational dynamics of the active end of amyloid fibril to elucidate mechanisms underlying the fibril elongation

2009 - 2010 糖脂質クラスターを舞台とする生体認識現象への分子構造論的アプローチ

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Papers (99)：

Maho Yagi-Utsumi, Yui Kanaoka, Shogo Miyajima, Satoru G. Itoh, Katsuhiko Yanagisawa, Hisashi Okumura, Takayuki Uchihashi, Koichi Kato. Single-Molecule Kinetic Observation of Antibody Interactions with Growing Amyloid β Fibrils. Journal of the american chemical society. 2024
Satoshi Nakagawa, Hiroyuki D Sakai, Shigeru Shimamura, Yoshiki Takamatsu, Shingo Kato, Hirokazu Yagi, Saeko Yanaka, Maho Yagi-Utsumi, Norio Kurosawa, Moriya Ohkuma, et al. N-linked protein glycosylation in Nanobdellati (formerly DPANN) archaea and their hosts. Journal of bacteriology. 2024. e0020524
Tadashi Satoh, Maho Yagi-Utsumi, Nozomi Ishii, Tsunehiro Mizushima, Hirokazu Yagi, Ryuichi Kato, Yuriko Tachida, Hiroaki Tateno, Ichiro Matsuo, Koichi Kato, et al. Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase involved in NGLY1 deficiency. FEBS letters. 2024
Satoshi Nakagawa, Hiroyuki Imachi, Shigeru Shimamura, Saeko Yanaka, Hirokazu Yagi, Maho Yagi-Utsumi, Hiroyuki Sakai, Shingo Kato, Moriya Ohkuma, Koichi Kato, et al. Characterization of protein glycosylation in an Asgard archaeon. BBA advances. 2024. 6. 100118-100118
Supaphorn Seetaha, Nuntaporn Kamonsutthipaijit, Maho Yagi-Utsumi, Yanaka Seako, Takumi Yamaguchi, Supa Hannongbua, Koichi Kato, Kiattawee Choowongkomon. Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors. The protein journal. 2023

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MISC (31)：

田所美璃, 中間貴寛, LIU Hongkun, 矢木真穂, 矢木真穂, 加藤晃一, 加藤晃一, 藤田誠, 藤田誠, 藤田誠. NMR structural analysis of protein-lipid interactions by confinement within isolated space of metallo-cages. 日本化学会春季年会講演予稿集(Web). 2024. 104th
小野寺悠太, 竹内絵里奈, 中間貴寛, 矢木真穂, 藤田大士, 加藤晃一, 藤田誠, 藤田誠, 藤田誠. NMR analysis of dimerization of amyloid β hydrophobic fragments by encapsulation in a giant spherical metallo-cage. 日本化学会春季年会講演予稿集(Web). 2024. 104th
海老原梨沙, 中間貴寛, 守島健, 杉山正明, 矢木真穂, 藤田誠, 藤田誠, 藤田誠. Single protein encapsulation in well-defined cavities of spherical complexes. 日本化学会春季年会講演予稿集(Web). 2024. 104th
伊藤暁, 矢木真穂, 加藤晃一, 奥村久士. アミロイドベータペプチドの凝集初期過程の分子シミュレーション-Molecular simulation on the early aggregation process of amyloid-β peptides. 細胞. 2023. 55. 10. 784-788
中間貴寛, ANOUK Rossen, 海老原梨沙, 矢木真穂, 矢木真穂, 藤田大士, 加藤晃一, 加藤晃一, 藤田誠, 藤田誠. Hysteretic unfolding-refolding of a protein confined in M₁₂L₂₄ spherical cages. ホスト-ゲスト・超分子化学シンポジウム講演要旨集. 2023. 20th

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Lectures and oral presentations (14)：

アミロイドβ線維の形成促進および形成阻害の分子機構の解明
(日本蛋白質科学会年会プログラム・要旨集 2023)
アミロイドβタンパク質の構造変化と分子集合
(日本生化学会大会(Web) 2023)
溶液内ミクロ環境の揺らぎを考慮したアミロイドβの構造解析
(日本薬学会年会要旨集 2022)
ガングリオシド膜上におけるアミロイドβの構造転移
(日本生化学会大会(Web) 2020)
ガングリオシド膜上におけるアミロイドβの固体NMR構造解析
(Abstracts. Annual Meeting of the NMR Society of Japan 2019)

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Education (3)：

2007 - 2010 Nagoya City University Graduate School of Pharmaceutical Sciences ph.D. course
2005 - 2007 Nagoya City University Graduate School of Parmaceutical Sciences Master course
2001 - 2005 Nagoya City University Pharmaceutical Sciences

Professional career (1)：

Ph.D. (Nagoya City University)

Work history (8)：

2022 - 現在 National Institutes of Natural Sciences Exploratory Research Center on Life and Living Systems (ExCELLS) Associate Professor (Adjunct)
2022 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences Assistant Professor
2018 - 2022 Exploratory Research Center on Life and Living Systems (ExCELLS) Assistant Professor
2015 - 2018 Institute for Molecular Science Life and Coordination-Complex Molecular Science Assistant Professor
2014 - Okazaki Institute for Integrative Bioscience Research Assistant Professor

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Awards (12)：

2024/10 - 名古屋市立大学令和6年度名古屋市立大学理事長賞研究B
2024/10 - 名古屋市立大学大学院薬学研究科令和5年度名古屋市立大学大学院薬学研究科教員個人評価優秀賞
2020/07 - National Institutes of Natural Sciences The 10th Young Researcher Award from National Institutes of Natural Sciences Molecular assemblies of amyloidogenic proteins
2018/03 - The Pharmaceutical Society of Japan The PSJ Award for Young Scientists
2011/06 - the Protein Science Society of Japan Young Scientist Award

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Association Membership(s) (6)：

THE NUCLEAR MAGNETIC RESONANCE SOCIET Y OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , PROTEIN SCIENCE SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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