Rchr
J-GLOBAL ID：201101008781193426   Update date: Sep. 22, 2024

Kiyonaka Shigeki

キヨナカ シゲキ | Kiyonaka Shigeki
Affiliation and department：
Nagoya University Graduate School of Engineering

About Nagoya University Graduate School of Engineering


Research field  (2)： Biochemistry ,  Neuroscience - general
Research keywords  (13)： 包括脳ネットワーク ,  統合脳・分子脳科学 ,  バイオセンサー ,  アセチルコリン受容体 ,  光アフィニティーラベル化 ,  アフィニティーラベル ,  TlpA ,  拮抗剤 ,  センサー ,  TRPチャネル ,  温度センサー ,  コイルドコイル ,  GFP
Research theme for competitive and other funds  (16)：
  • 2024 - 2029 デザイナーリガンドで制御可能な受容体の創成および生成的デザイン
  • 2019 - 2024 タンパク質の非平衡状態構造解析を可能にするケミカル光制御法の開発
  • 2020 - 2023 Reverse structural biology of conformational dynamics and signal transduction mechanisms of taste receptors
  • 2020 - 2023 Development of a novel chemogenetic tool for in vivo regulation of the target GPCR
  • 2016 - 2019 Development of novel methods for allosteric activation of receptor subtypes on cell surface
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Papers (161)：
  • Rohit M Vaidya, Jiahao Zhang, Duncan Nall, Yongjae Lee, Eung Chang Kim, Donghan Ma, Fang Huang, Hiroshi Nonaka, Shigeki Kiyonaka, Itaru Hamachi, et al. Nanoscale organization is changed in native, surface AMPARs by mouse brain region and tauopathy. bioRxiv : the preprint server for biology. 2024
  • Hiroshi Nonaka, Seiji Sakamoto, Kazuki Shiraiwa, Mamoru Ishikawa, Tomonori Tamura, Kyohei Okuno, Takumi Kondo, Shigeki Kiyonaka, Etsuo A Susaki, Chika Shimizu, et al. Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 6. e2313887121
  • Hiroshi Nonaka, Takeharu Mino, Seiji Sakamoto, Jae Hoon Oh, Yu Watanabe, Mamoru Ishikawa, Akihiro Tsushima, Kazuma Amaike, Shigeki Kiyonaka, Tomonori Tamura, et al. Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes. Chem. 2023. 9. 2. 523-540
  • Kento Ojima, Wataru Kakegawa, Tokiwa Yamasaki, Yuta Miura, Masayuki Itoh, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Eriko Miura, Hiroshi Nonaka, et al. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Nature communications. 2022. 13. 1. 3167-3167
  • Yuta Miura, Akinobu Senoo, Tomohiro Doura, Shigeki Kiyonaka. Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches. RSC Chemical Biology. 2022
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MISC (47)：
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Books (1)：
  • Chapter21 Receptor Signaling Integration by TRP Channelsomes
    Springer Science 十Business Media B.V. 2011
Professional career (1)：
  • 博士(工学) (九州大学)
Work history (4)：
  • 2019/03 - 現在 Nagoya University Graduate School of Engineering
  • 2010/08 - 2019/02 Kyoto University Graduate School of Engineering
  • 2011/04 - 2016/03 Kyoto University Hall of Global Environmental Research
  • 2005/10 - 2010/07 Kyoto University Graduate School of Engineering
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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