morinobu shigeru

Research field (1)： Psychiatry

Research keywords (32)：包括脳ネットワーク , 統合脳・病態脳 , 電気けいれん治療 , アセチル化 , forskolin , phosdhodiesterase , 転写因子 , Phrsphodiesterasc , ATF-2 , c-Jun N-terminal kinase (JNK) , phosphodiesterase , 探索行動 , p38 , バルプロ酸 , ストレス性精神障害 , JNK interacting protein (JIP) , うつ病モデル , c-Jun NH2-terminal Kinase (JNK) , 母子分離ストレス , trk B , 拘束ストレス , ヒストン・アセチル化 , うつ病 , Trk-B , 抗うつ薬 , GDNF , 難治性うっ病 , 海馬 , リン酸化 , BDNF , ストレス , 母子分離

Research theme for competitive and other funds (28)：

2022 - 2025 DNAメチル化障害とその量的形質遺伝子座を用いた健康支援研究のモデル開発
2022 - 2025 Elucidation of the involvement of RNA methylation in impairment of fear memory extinction in PTSD and development of a new therapy
2018 - 2022 Combination treatment of stem cell and exercise therapies in a Wistar Kyoto rat model of traumatic brain injury
2018 - 2021 Development of newer animal model, biomarker, and treatment of depression by regulation of BDNFgene methylation using genome editing
2017 - 2020 Driving assessment in DLB

2015 - 2018 A longitudinal study of epigenetic epidemiology for the primary and secondary prevention of elderly depression

2015 - 2018 Development of the therapeutic biomarker in bipolar disorder using CNV and methylation of target genes of mood stabilizers

2013 - 2016 Screening and development of drugs that can contribute to the treatment of intractable neuropsychiatric disease by regulating membrane trafficking and lysosomal degradation.

2011 - 2016 Integrating molecular and psychosocial approach for assisting adolescent mind development and self-regulation

2013 - 2015 エピジェネティクスと組織化学的手法によるPTSDの病態解明と予防法の開発

2012 - 2015 A study on brain mechanisms of emotional control and restoring mechanisms to their disturbance

2012 - 2015 Epidemiologic study on epigenetics related to BDNF for primary and secondary prevention of depression in the elderly

2011 - 2013 Can exercise maintain and/or improve age-related changes in function and morphology of nervous system responsible for postural and locomotor control?

2011 - 2013 Development of the biomarker for suicide prediction using the methylation at the gene promoters

2009 - 2010 The role of pro-domain BDNF in depression

2008 - 2009 Elucidation of pathophysiology of refractory depression and development of newer treatment based on the disturbance of spine dynamics

2008 - 2009 エピジェネティクスと大脳白質微細構造によるうつ病発症・難治化の機序解明

2008 - 2009 クロマチン・リモデニングからみた新たなうつ病の病態解明と治療法開発の糸口発見

2006 - 2008 The study of vulnerability for PTSD and the development of newer treatment using PTSD model rats

2006 - 2007 エピジェネティクスによるうつ病発症・難治化の機序解明

2005 - 2007 Elucidation of the epigenetic mechanism of stress-related mental disorders-Identification of the transcriptional dysfunction in response to early environments and development of a new therapeutic strategy-

2002 - 2004 Study on Emotional Neuroplasticity in the Pathophysiology of Affective Disorders

2002 - 2004 Research for the involvement of the JNKs/c-Jun axis in the pathogenesis of stress-related psychiatric disorders

2001 - 2003 Analysis of signal transduction mediated by neurosteroids as molecular mechanisms of emotion

1998 - 2001 The involvement of the dysfunction of transcrption factor in the pathogenesis of stress-related psychiatric disorders

1995 - 1997 The involvement of the BDNF signal transduction to the pathogenesis of ssstress-related psychiatric disorders

1992 - 1994 加齡による中枢神経伝達機能の変化とコリン作動薬の作用に関する研究

1988 - 1989 ACETYLCHOLINESTERASE INHIBITOR TREATMENT OF PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE

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Papers (124)：

Yoshikazu Maeno, Manabu Fuchikami, Koichiro Fujimaki, Israel Liberzon, Shigeru Morinobu. Long-term mental health and resilience of the first responders in Japanese ground self-defense forces engaging body recovery after the great east Japan earthquake. Journal of psychiatric research. 2024. 173. 381-386
Yukiko Masumoto, Shigeru Morinobu, Koichiro Fujimaki, Keiko Kasagi. Important factors in the observation dimensions of high school Yogo teachers to detect prodromal symptoms of mental health issues in adolescents. Journal of Affective Disorders Reports. 2021. 5. 100173-100173
Jun Omura, Manabu Fuchikami, Motoaki Araki, Tatsuhiro Miyagi, Yasumasa Okamoto, Shigeru Morinobu. Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2021. 108. 110090-110090
Kouichi Hashimoto, Yosuke Yamawaki, Kenji Yamaoka, Takayuki Yoshida, Kana Okada, Wanqin Tan, Miwako Yamasaki, Yoshiko Matsumoto-Makidono, Reika Kubo, Hisako Nakayama, et al. Spike firing attenuation of serotonin neurons in learned helplessness rats is reversed by ketamine. Brain communications. 2021. 3. 4. fcab285
Motoaki Araki, Manabu Fuchikami, Jun Omura, Tatsuhiro Miyagi, Nobuyuki Nagashima, Yasumasa Okamoto, Shigeru Morinobu. The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumatic stress disorder. Psychopharmacology. 2020. 237. 7. 2125-2137

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MISC (276)：

Tatsuo Akechi, Tadashi Kato, Norio Watanabe, Shiro Tanaka, Toshi A. Furukawa, Toshi A. Furukawa, Tatsuo Akechi, Shinji Shimodera, Mitsuhiko Yamada, Masatoshi Inagaki, et al. Predictors of hypomanic and/or manic switch among patients initially diagnosed with unipolar major depression during acute-phase antidepressants treatment. PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2019. 73. 2. 90-91
須賀楓介, 土居江里奈, 赤松正規, 森信繁. 難治性うつ病として治療されていたPTSDの1例. 精神神経学雑誌. 2018. 120. 2. 147-147
中村京子, 上村直人, 今城由里子, 森澤陽子, 古谷博和, 下寺信次, 森信繁. 大学病院における基幹型認知症疾患医療センターの役割と課題(1). 精神神経学雑誌. 2018. 120. 2. 150-150
上村直人, 中村京子, 今城由里子, 森澤陽子, 古谷博和, 下寺信次, 森信繁. 大学病院における基幹型認知症疾患医療センターの役割と課題受診目的からの分析と傾向. 精神神経学雑誌. 2018. 120. 2. 150-150
高村祥吾, 赤松正規, 上村直人, 下寺信次, 森信繁, 宮本由賀, 古谷博和. 妄想を伴った神経核内封入体病の1例. 精神神経学雑誌. 2018. 120. 2. 153-153

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Professional career (1)：

医学博士 (山形大学)

Work history (15)：

2017/04 - 現在 Kibi International University School of Health Science and Social Welfare
2013/09 - 2017/03 Kochi University Medical School
2011/04 - 2013/08 広島大学大学院医歯薬学研究院精神神経医科学特任教授
2008 - 2011 広島大学医歯薬学総合研究科准教授
2004 - 2007 広島大学医歯薬学総合研究科助教授

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