Rchr
J-GLOBAL ID:201101024180670923   Update date: Nov. 16, 2024

Yamaguchi Yoshiki

ヤマグチ ヨシキ | Yamaguchi Yoshiki
Affiliation and department:
Job title: 教授
Research field  (2): Pharmaceuticals - chemistry and drug development ,  Pharmaceuticals - analytical and physicochemistry
Research keywords  (13): データベース ,  質量分析 ,  構造生物学 ,  レクチン ,  ダイナミクス ,  生物物理 ,  脳神経疾患 ,  安定同位体標識 ,  分子認識 ,  糖タンパク質 ,  薬学 ,  NMR ,  糖鎖
Research theme for competitive and other funds  (40):
  • 2024 - 2027 細胞表面糖鎖クラスターの構造-機能相関と予測基盤の開発
  • 2022 - 2025 Elucidation of molecular mechanism for IgG levels regulated by L-fucose
  • 2019 - 2024 Biology of sugar-alcohol modification in glycan
  • 2019 - 2022 Study on structure and interaction of branched glycans
  • 2018 - 2021 新規リビトールリン酸糖鎖の修飾機序の解明と生理活性の治療応用
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Papers (331):
  • Xiao Xu, Noriyoshi Manabe, Shiho Ohno, Sachiko Komatsu, Tsutomu Fujimura, Yoshiki Yamaguchi. 3D structural insights into the effect of N-glycosylation in human chitotriosidase variant G102S. Biochimica et Biophysica Acta (BBA) - General Subjects. 2025. 1869. 1. 130730-130730
  • Shino Manabe, Shogo Iwamoto, Satoru Nagatoishi, Asako Hoshinoo, Ai Mitani, Wataru Sumiyoshi, Takashi Kinoshita, Yoshiki Yamaguchi, Kouhei Tsumoto. Systematic Preparation of a 66-IgG Library with Symmetric and Asymmetric Homogeneous Glycans and Their Functional Evaluation. Journal of the American Chemical Society. 2024
  • Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, et al. Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases. Neuron. 2024
  • 稲森 啓一郎, 宍戸 史, 許 家甄, 永福 正和, 新田 昂大, 中村 勝哉, 土田 奈緒美, 池田 淳司, 小平 農, 栂谷内 晶, et al. 神経変性症患者および一般住民に見出された新規B4GALNT1(GM2合成酵素)バリアントの機能解析. 脂質生化学研究. 2024. 66. 238-240
  • Shiho Ohno, Noriyoshi Manabe, Jun Uzawa, Yoshiki Yamaguchi. Comparative Conformational Analysis of Acyclic Sugar Alcohols Ribitol, Xylitol and d-Arabitol by Solution NMR and Molecular Dynamics Simulations. Molecules. 2024. 29. 5. 1072-1072
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MISC (131):
  • 中村 勝哉, 土田 奈緒美, 井ノ口 仁一, 小島 朋美, 池田 淳司, 小平 農, 稲森 啓一郎, 永福 正和, 新田 昂大, 真鍋 法義, et al. 本邦初のB4GALNT1関連神経変性症の臨床的特徴. 臨床神経学. 2022. 62. Suppl. S208-S208
  • 大野詩歩, 大内陽翔, 齋藤祐希, 真鍋法義, 湯浅徳行, 松崎祐二, 築地信, 川嵜敏祐, 山口芳樹. NMRデータを組み入れた抗糖鎖抗体のドッキングシミュレーション. 構造活性相関シンポジウム講演要旨集. 2022. 50th (CD-ROM)
  • 青木英莉子, 真鍋法義, 大野詩歩, 青木大芽, 古川潤一, 栂谷内晶, 木下聖子, 井ノ口仁一, 黒澤健司, 要匡, et al. A new method for diagnosis and predicting X-linked recessive brachytelephalangic chondrodysplasia punctata: Computational analysis and identification of novel missense mutation. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 要匡, 太田隼人, 柳久美子, 花松久寿, PECORI Federico, 古川潤一, 山口芳樹, 上原朋子, 井ノ口仁一, 木下聖子, et al. Genes to diagnosis and therapy in glycogenomics disorders: The example of GDP-fucose transporter deficiency, a rare disease. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 西原祥子, 木下聖子, 栂谷内晶, 細田正恵, 伊藤和義, 山口芳樹, 真鍋法義, 大野詩歩, 稲森啓一郎, 井ノ口仁一, et al. Comprehensive extraction and analysis of the whole human glycan-related gene variant. 日本糖質学会年会要旨集. 2021. 40th
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Books (19):
  • Adv. Chem. Res. : Mannose as a component of glycans : Structure, dynamics and interaction.
    2020
  • Curr Top Microbiol Immunol. : Structural Aspects of Carbohydrate Recognition Mechanisms of C-Type Lectins.
    2019
  • Glycoscience: Basic Science to Applications
    2019 ISBN:9789811358555
  • Glycoscience: Basic Science to Applications
    2019 ISBN:9789811358555
  • Glycoscience: Basic Science to Applications
    2019 ISBN:9789811358555
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Work history (7):
  • 2021/04 - 現在 Tohoku Medical and Pharmaceutical University Division of Structural Glycobiology Professor
  • 2019/04 - 2021/03 Tohoku Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences
  • 2018/04 - 2019/03 理化学研究所 伊藤細胞制御化学研究室 研究員
  • 2007/10 - 2018/03 理化学研究所 糖鎖構造生物学研究チーム チームリーダー
  • 2001/06 - 2007/09 Nagoya City University Graduate School of Pharmaceutical Sciences
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Association Membership(s) (11):
Society for Glycobiology ,  ASBMB ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  THE SPECTROSCOPICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH
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