Yamaguchi Yoshiki

ヤマグチヨシキ | Yamaguchi Yoshiki

Affiliation and department：
Job title：教授

Research field (2)： Pharmaceuticals - chemistry and drug development , Pharmaceuticals - analytical and physicochemistry

Research keywords (13)：データベース , 質量分析 , 構造生物学 , レクチン , ダイナミクス , 生物物理 , 脳神経疾患 , 安定同位体標識 , 分子認識 , 糖タンパク質 , 薬学 , NMR , 糖鎖

Research theme for competitive and other funds (39)：

2022 - 2025 Elucidation of molecular mechanism for IgG levels regulated by L-fucose
2019 - 2024 Biology of sugar-alcohol modification in glycan
2019 - 2022 Study on structure and interaction of branched glycans
2018 - 2021 新規リビトールリン酸糖鎖の修飾機序の解明と生理活性の治療応用
2016 - 2021 Chemical Biology of ER Related Glycan Modifications

2018 - 2020 新規リビトールリン酸糖鎖の修飾機序の解明と生理活性の治療応用

2016 - 2019 Structural biology study on the interactions between lectins and branched glycans

2014 - 2019 Development of imaging-based diagnostic procedures for brain protein aging

2015 - 2018 Elucidation of structure, modification mechanism, pathophysiological roles of a novel posttranslational modification, post-phosphoryl sugar chain

2016 - 2018 Structural biology study on the interactions between lectins and branched glycans

2014 - 2018 脳イメージングを基軸としたタンパク質老化モデルの治療評価系の開発

2014 - 2017 Synthesis of chemical probes containing di/oligosialialic acids and their biological evaluation related to innate immunity

2013 - 2017 Structural analysis of asymmetrically branched glycans

2015 - 2017 新型の翻訳後修飾“ポストリン酸糖鎖”の全構造・修飾機序・病態生理的意義の解明

2013 - 2016 Novel regulatory mechanism for intracellular calcium ion concentration by membrane microdomain-localized glycans in sperm

2013 - 2016 Modeling and database development for complex glycans

2013 - 2016 Structural analysis of asymmetrically branched glycans

2013 - 2015 The creation of co-chaperone HOP inhibitor for cancer therapy.

2013 - 2014 Prediction of Protein-Glycan Structure Complex with Low Binding Affinity

2011 - 2014 The synthesis of biologically active oligosaccharides in symbiosis and immunity

2010 - 2012 Expression of novel carbohydrate-specific single chain antibodies in E. coli and analyses of carbohydrate-binding activities of purified antibodies

2010 - 2011 糖鎖が関わる小胞体関連分解の構造生物学的研究

2006 - 2010 Structural analysis of the intracellular proteolytic system

2008 - 2009 NMR構造生物学に基づいた薬物相互作用の解析と神経変性疾患への治療応用

2007 - 2008 Development of structural analysis of oligosaccharides by stable isotope labeling techniques

2006 - 2007 Design of taste-modifying molecules based on the analysis of the structure and function of taste-modifying protein, curculin.

2006 - 2007 Structural basis of the interplay between the carbohydrate recognition and protein ubiquitination systems in the glycoprotein degradation in cells

2006 - 2007 NMR構造生物学による神経変性疾患の発症機構の解析

2005 - 2006 味覚修飾タンパク質クルクリンの機能発現メカニズムの解明とその応用

2005 - 2006 Structural glycomics by NMR

2005 - 2006 NMRと糖鎖ライブラリーを利用した糖タンパク質の細胞内運命の決定機構の研究

2005 - 2005 ユビキチン・プロテアソーム系の破綻に起因する神経変性疾患のNMR構造生物学

2004 - 2005 糖鎖を認識するユビキチンリガーゼの構造生物学的解析

2004 - 2004 糖タンパク質の構造グライコミクスを展開するためのデータベースの拡張と応用

2003 - 2004 タンパク質社会における糖鎖の機能解明を目指したNMR構造生物学

2003 - 2004 糖タンパク質の構造グライコミクスを展開するためのデータベースの構築

2002 - 2003 小胞体分子シャペロン・カルレティキュリンの糖タンパク質認識メカニズムの解明

1998 - 1999 NMRを用いた糖タンパク質の高次構造解析

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Papers (323)：

Shiho Ohno, Noriyoshi Manabe, Jun Uzawa, Yoshiki Yamaguchi. Comparative Conformational Analysis of Acyclic Sugar Alcohols Ribitol, Xylitol and d-Arabitol by Solution NMR and Molecular Dynamics Simulations. Molecules. 2024. 29. 5. 1072-1072
Ryoka Kokubu, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi. Solution NMR Analysis of O-Glycopeptide-Antibody Interaction. Methods in Molecular Biology. 2024. 321-327
Ryoka Kokubu, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi. Molecular Dynamics Simulation and Docking of MUC1 O-Glycopeptide. Methods in Molecular Biology. 2024. 373-379
Shunli Pan, Noriyoshi Manabe, Shiho Ohno, Sachiko Komatsu, Tsutomu Fujimura, Yoshiki Yamaguchi. Each N-glycan on human IgA and J-chain uniquely affects oligomericity and stability. Biochimica et Biophysica Acta (BBA) - General Subjects. 2024. 1868. 2. 130536-130536
Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi. Prediction of protein structure and AI. Journal of Human Genetics. 2024

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MISC (130)：

大野詩歩, 大内陽翔, 齋藤祐希, 真鍋法義, 湯浅徳行, 松崎祐二, 築地信, 川嵜敏祐, 山口芳樹. NMRデータを組み入れた抗糖鎖抗体のドッキングシミュレーション. 構造活性相関シンポジウム講演要旨集. 2022. 50th (CD-ROM)
青木英莉子, 真鍋法義, 大野詩歩, 青木大芽, 古川潤一, 栂谷内晶, 木下聖子, 井ノ口仁一, 黒澤健司, 要匡, et al. A new method for diagnosis and predicting X-linked recessive brachytelephalangic chondrodysplasia punctata: Computational analysis and identification of novel missense mutation. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
要匡, 太田隼人, 柳久美子, 花松久寿, PECORI Federico, 古川潤一, 山口芳樹, 上原朋子, 井ノ口仁一, 木下聖子, et al. Genes to diagnosis and therapy in glycogenomics disorders: The example of GDP-fucose transporter deficiency, a rare disease. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
西原祥子, 木下聖子, 栂谷内晶, 細田正恵, 伊藤和義, 山口芳樹, 真鍋法義, 大野詩歩, 稲森啓一郎, 井ノ口仁一, et al. Comprehensive extraction and analysis of the whole human glycan-related gene variant. 日本糖質学会年会要旨集. 2021. 40th
大野礼一, 田中誠太郎, 伴郁穂, 勝田奈那, 富永悠幹, 谷口直之, 山口芳樹, 伊藤恵実, 永井竜児. 糖尿病ラット水晶体におけるポリオール経路由来新規AGEsの蓄積評価. 日本抗加齢医学会総会プログラム・抄録集. 2020. 20回. 196-196

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Books (19)：

Adv. Chem. Res. : Mannose as a component of glycans : Structure, dynamics and interaction.
2020
Curr Top Microbiol Immunol. : Structural Aspects of Carbohydrate Recognition Mechanisms of C-Type Lectins.
2019
Glycoscience: Basic Science to Applications
2019 ISBN:9789811358555
Glycoscience: Basic Science to Applications
2019 ISBN:9789811358555
Glycoscience: Basic Science to Applications
2019 ISBN:9789811358555

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Work history (7)：

2021/04 - 現在 Tohoku Medical and Pharmaceutical University Division of Structural Glycobiology Professor
2019/04 - 2021/03 Tohoku Medical and Pharmaceutical University Faculty of Pharmaceutical Sciences
2018/04 - 2019/03 理化学研究所伊藤細胞制御化学研究室研究員
2007/10 - 2018/03 理化学研究所糖鎖構造生物学研究チームチームリーダー
2001/06 - 2007/09 Nagoya City University Graduate School of Pharmaceutical Sciences

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Association Membership(s) (11)：

Society for Glycobiology , ASBMB , THE BIOPHYSICAL SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE SPECTROSCOPICAL SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH

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