Mukai Hideyuki

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://bioupdate.jp

Research field (8)： Molecular biology , Dermatology , Neurology , Structural biochemistry , Pathobiochemistry , Molecular biochemistry , Cell biology , Functional biochemistry

Research keywords (32)： substrate specificity , SH3 protein , two-hybrid system , small GTPase , RhoB , RhoA , 蛋白質燐酸化酵素 , PKN beta , ストレス , 長期増強(long term potentiation) , 長期抑圧(long term depression) , 海馬 , actinin , CKAR , FRET , YFP , PRK2 , PKN1 , Golgi , small GTPase Rho , ノックアウトマウス , 細胞内局在 , CFP , PKN family , polyproline sequence , knockout mouse , NKAR , protein kinase , Rho , PKN , 包括脳ネットワーク , 統合脳・分子脳科学

Research theme for competitive and other funds (27)：

2021 - 2024 不安を緩衝する腹側海馬神経回路の探索
2018 - 2023 ストレス誘発性不安緩衝における海馬歯状回抑制性細胞の重要性
2017 - 2020 Analysis on the suppression of cancer metastasis by PKN3 inhibition
2014 - 2018 Involvement of glutamate transporters in central stress response
2011 - 2015 タウ蛋白とリン酸化酵素複合体の相互作用を介した認知症脳神経細胞死の病態解析

2011 - 2015 PKN1 regulates metaplasticity in hippocampus

2014 - 2015 タウ蛋白リン酸化シグナル巨大複合体を介する変性認知症の神経細胞死に関する病態解析

2011 - 2013 Functional analysis of separase and its novel substrate in the licensing of centrosome duplication

2010 - 2012 Pharmacogenomic study on the drug-sensitive genes using model organisms

2008 - 2010 Pathological study for a protein anchoring tau kinases and tau phosphatases in Alzheimer brain tissues

2008 - 2010 Regulation of the maturation of cerebellar synapses by PKN

2006 - 2007 Research of signal transduction to neuronal degeneration mediated by tau-kinases complex in dementia

2006 - 2007 An analysis of the role of protein kinase PKN3 in the progress of cancer and a development of new anticancer agent

2006 - 2007 蛋白質リン酸化酵素PKN1ノックアウトマウスを用いた記憶・学習機構の解析

2005 - 2007 Functional regulation of centrosome and Golgi apparatus by signal-anchoring proteins.

2004 - 2005 Research of signal transduction to neuronal degeneration mediated by tau phorphorylation in dementia

2003 - 2004 Role of β isoform of protein kinase C in hepatocyte growth factor-induced signal transduction in pigment cells

2003 - 2004 To clarify the mechanism of activation of PKN and the interaction with target molecules in vivo

2002 - 2003 Study of signal transduction to neuronal death through tau phosphorylation

2001 - 2002 Study of the role of protein kinase C-phosphoipase D signaling pathway in pigment cells.

1999 - 2000 PKNファミリーの細胞内伝達機構における機能解析

1997 - 2000 細胞内情報伝達機構網の研究

1997 - 1998 Study on the stress-induced signaling pathway of PKN

1997 - 1997 細胞内増殖機構における蛋白質リン酸化酵素PKNの機能に関する研究

1996 - 1997 Studies on the structure and function of protein kinase PKN

1996 - 1996 細胞内増殖機構における蛋白質リン酸化酵素PKNの機能に関する研究

1996 - 1996 蛋白質燐酸化酵素PKNと相互作用する蛋白因子の同定

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Papers (93)：

Shunsuke Uehara, Hideyuki Mukai, Teruhito Yamashita, Masanori Koide, Kohei Murakami, Nobuyuki Udagawa, Yasuhiro Kobayashi. Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice. Journal of Bone and Mineral Metabolism. 2022. 40. 2. 251-261
Atsushi Kawase, Hideyuki Mukai, Shunsuke Tateishi, Shintaro Kuroda, Akira Kazaoka, Ryosuke Satoh, Hiroaki Shimada, Reiko Sugiura, Masahiro Iwaki. Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice. The Journal of pharmacology and experimental therapeutics. 2021. 379. 1. 53-63
Koji Kubouchi, Hideyuki Mukai. PKN2 is involved in aggregation and spheroid formation of fibroblasts in suspension culture by regulating cell motility and N-cadherin expression. Biochemistry and Biophysics Reports. 2021. 25. 100895-100895
Hiroki Yasuda, Hikaru Yamamoto, Kenji Hanamura, Mona Mehruba, Toshio Kawamata, Hiromi Morisaki, Masaaki Miyamoto, Shinji Takada, Tomoaki Shirao, Yoshitaka Ono, et al. PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Communications Biology. 2020. 3. 1
上原俊介, 山下照仁, 村上康平, 小出雅則, 宇田川信之, 小林泰浩, 向井秀幸. プロテインキナーゼN3(Pkn3)阻害剤は、卵巣切除に伴う骨量減少を骨吸収抑制により軽減する. 日本骨代謝学会学術集会プログラム抄録集. 2020. 38回. 128-128

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MISC (25)：

窪内康二, 團野紗莉, 野町昭, 平田多佳子, 松尾一彦, 中山隆志, 佐藤亮介, 杉浦麗子, 阿部学, 崎村建司, et al. PKN1はリンパ球の細胞運動・トラフィッキングを制御する. 生命科学系学会合同年次大会. 2017. 2017年度. [1P-0369]
上原俊介, 山下照仁, 中村貴, 加藤茂明, 宇田川信之, 高橋直之, 小林泰浩, 西田満, 南康博, 向井秀幸, et al. Wnt5a-Ror2シグナルによる骨吸収活性調節の病態モデルにおける役割. 日本骨代謝学会学術集会プログラム抄録集. 2017. 35回. 158-158
Sally Danno, Koji Kubouchi, Mona Mehruba, Manabu Abe, Rie Natsume, Kenji Sakimura, Satoshi Eguchi, Masahiro Oka, Takeshi Fukumoto, Masanori Hirashima, et al. PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts (vol 22, pg 220, 2017). GENES TO CELLS. 2017. 22. 3. 328-328
Hiroki Yasuda, Yoshitaka Ono, Hideyuki Mukai. Synaptic maturation by PKN during development. NEUROSCIENCE RESEARCH. 2009. 65. S82-S82
中川泰介, 菅田陽怜, 松尾和彦, 高橋美樹子, 向井秀幸, 小野功貴, 前田潔, 秋山治彦, 川又敏男. アルツハイマー病におけるPDK1活性化の検討. Dement Jpn. 2008. 22. 2. 171

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Patents (1)：

PKN1ノックアウト動物、および向精神薬開発法

Books (13)：

Neuromethods:Protein kinase technologies
2012
Protein kinase Technologies
Springer-Verlag 2012
Welcome to ゲノムワールドゲノム創薬科学最前線
京都廣川書店 2010
Methods in Enzymology:Regulators and Effectors of Small GTPases: Rho Family
Elsevier 2006
Protein kinase C Protocols
Humana Press 2003

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Lectures and oral presentations (1)：

PKN Interacting Proteins
(International Conference on Molecular Biology Transcription/Replication Factors and Signal Transduction 1999)

Professional career (1)：

M.D., Ph.D.

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