Rchr
J-GLOBAL ID：201101025641155755   Update date: Jan. 31, 2024

Kanao Rie

カナオ リエ | Kanao Rie
Affiliation and department：
Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection

About Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection


Job title： Assistant Professor
Research field  (3)： Molecular biology ,  Environmental effects of chemicals ,  Environmental effects of radiation
Research keywords  (2)： Translesion Synthesis ,  DNA damage tolerance
Research theme for competitive and other funds  (6)：
  • 2021 - 2024 PCNAのユビキチン化で制御される新規DNA損傷トレランス経路の解析
  • 2018 - 2021 Analysis of DNA damage tolerance mediated by multi-modification of PCNA homo-trimer
  • 2014 - 2017 Rescue of arrested replication forks by multiple ubiquitination of PCNA
  • 2013 - 2016 Analysis of mechanisms to tolerate for DNA replication blockage at DNA lesions
  • 2012 - 2015 Biochemical study on the molecular mechanisms of induced mutagenesis and post-replication repair pathways
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Papers (13)：
  • Yohei Sugimoto, Yuji Masuda, Shigenori Iwai, Yumi Miyake, Rie Kanao, Chikahide Masutani. Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans. Nucleic acids research. 2023. 51. 10. 4959-4981
  • Rie Kanao, Hidehiko Kawai, Toshiyasu Taniguchi, Minoru Takata, Chikahide Masutani. RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance. Life science alliance. 2022. 5. 12. e202201584
  • Masuda Y, Kanao R, Kawai H, Kukimoto I, Masutani C. Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates. The Journal of biological chemistry. 2019
  • Masuda Y, Mitsuyuki S, Kanao R, Hishiki A, Hashimoto H, Masutani C. Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway. Nucleic acids research. 2018. 46. 21. 11340-11356
  • Rie Kanao, Chikahide Masutani. Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2017. 803. 82-88
ｍore...
Education (1)：
  • 2006 - 2009 Osaka University
Work history (3)：
  • 2010/11 - 現在 Nagoya University Research Institute of Environmental Medicine Assistant Professor
  • 2010/09 - 2010/10 Nagoya University Research Institute of Environmental Medicine
  • 2009/04 - 2010/08 Osaka University
Association Membership(s) (4)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE CANCER ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  日本放射線影響学会
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