Ueki Takatoshi

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/60317328

Research field (4)： Anatomy , Metabolism and endocrinology , Basic brain sciences , Neuroscience - general

Research keywords (18)：包括脳ネットワーク , 神経幹細胞 , 神経細胞死 , 虚血 , 骨形成因子 , Fra-2 , EGF , 幹細胞療法 , PD98059 , in vivoイメージング , PET , 神経新生 , ギャップ結合 , bFGF , MAPキナーゼ , connexin-43 , 精神・神経疾患 , アストロサイト

Research theme for competitive and other funds (22)：

2021 - 2026 脳血流量の変化を指標とした慢性疼痛患者の脳機能評価
2019 - 2023 Effect and mechanisms of rehabilitative exercise on depression
2019 - 2022 Establish of PET imaging system for analysis of adult neurogenesis
2018 - 2022 Molecular biological approaches in the treatment of ASIC1a locomotive syndrome.
2017 - 2021 Creation of preventive / delayed medical technology for the onset of schizophrenia targeting ADAM10

2016 - 2019 Development of analytical technology of pathological protease activity based on MRI, and its application for the prevention of schizophrenia

2015 - 2018 Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange

2015 - 2018 Development of in vivo molecular imaging system to analyze microglial behavior in the brain, and its application for early diagnosis of schizophrenia

2013 - 2018 neuroanatomical analysis of neuron-glia correlation in neuronal circuit maturation

2013 - 2018 Glial assembly:a new regulatory machinery of brain function and disorders

2014 - 2017 Development of in vivo imaging of protective and detrimental microglial activities for treating mental disorders

2014 - 2017 In vivo imaging study for the timing of neurogenesis and neuroinflammation altered in Alzheimer's disease

2013 - 2016 Latent neuroinflamation hypothesis on schizoprenia

2011 - 2014 Functional analysis of microglia as a therapeutic target of schizophrenia

2011 - 2014 In vivo imaging of the activity of ganma-secretase for amyloid production in Alzheimer's disease

2011 - 2013 Development of a monitoring system of in vivo cell dynamics for therapeutic evaluation of psychiatric disorders

2010 - 2012 Frontal lobe abnormalities in alcoholics: a multimodal molecular imaging study

2009 - 2011 Development of PET imaging system to visualize adult neurogenesis

2009 - 2010 iPS細胞技術を応用した統合失調症の疾患特異的幹細胞の作出とその機能解析

2008 - 2010 Neuronal stem cell imaging and analysis of non-human primates brain

2001 - 2002 アストロサイトにおけるギャップ結合の透過性調節の分子機構の解明

2000 - 2002 Reevaluation of neuronal cell death mechanisms in ischemic model animals

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Papers (47)：

Shinnosuke Koketsu, Kohki Matsubara, Yoshino Ueki, Yoshiaki Shinohara, Koichi Inoue, Satona Murakami, Takatoshi Ueki. The defects of the hippocampal ripples and theta rhythm in depression, and the effects of physical exercise on their amelioration. Heliyon. 2024. 10. 1
Tomoyasu Yamanaka, Takatoshi Ueki, Mitsuhito Mase, Koichi Inoue. Arbitrary Ca2+ regulation for endothelial nitric oxide, NFAT and NF-κB activities by an optogenetic approach. Frontiers in Pharmacology. 2023. 13
Hiromu Monai, Shinnosuke Koketsu, Yoshiaki Shinohara, Takatoshi Ueki, Peter Kusk, Natalie L. Hauglund, Andrew J. Samson, Maiken Nedergaard, Hajime Hirase. Author Correction: Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization. Scientific Reports. 2022. 12. 1. 4741
Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T. Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, et al. Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro. Communications Biology. 2022. 5. 1. 358
Ryota Hikiami, Toshifumi Morimura, Takashi Ayaki, Tomoyuki Tsukiyama, Naoko Morimura, Makiko Kusui, Hideki Wada, Sumio Minamiyama, Akemi Shodai, Megumi Asada-Utsugi, et al. Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates. Scientific Reports. 2022. 12. 1. 16030-16030

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MISC (12)：

纐纈真之介, 纐纈真之介, 纐纈真之介, 松原弘記, 植木美乃, 篠原良章, 井上浩一, 村上里奈, 植木孝俊. 運動が海馬活動障害とうつ病態を改善する神経基盤の解明. 日本脳科学会プログラム・講演抄録集. 2023. 50th
植木孝俊, 加賀城進. インタビュー・ルーム(1027)献体活用で手術トレーニング植木孝俊さん(51) 名古屋市立大学病院先端医療技術イノベーションセンター長. 厚生福祉. 2017. 6309. 13-13
植木孝俊, 尾内康臣, 間賀田泰寛, 小川美香子, 岡戸晴生. A-15 成体脳神経新生のin vivo 動態解析技術の創出. 霊長類研究所年報. 2014. 44. 44. 83-83
Takatoshi Ueki, Hiromu Furukawa, Gandhervin Kesavamoorthy, Kohji Sato, Yasuomi Ouchi. Development of molecular imaging system to visualize the processing of CD44 in NG2 cell, and its application to stem cell therapy for multiple sclerosis. NEUROSCIENCE RESEARCH. 2011. 71. E196-E196
尾内康臣, 横倉正倫, 八木俊輔, 菊知充, 吉川悦次, 二ツ橋昌実, 大星有美, 坂本政信, 植木孝俊. アルツハイマー病におけるミクログリア活性とアミロイド沈着の変化について(Alterations in microglial activation and amyloid deposits in Alzheimer's disease). 神経化学. 2010. 49. 2-3. 666-666

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Professional career (1)：

医学博士

Work history (1)：

2009 - 2013 Hamamatsu University School of Medicine Department of Anatomy and Neuroscience Associate Professor

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