araki toshiyuki

Affiliation and department：
Other affiliations (1)：

Tokyo University of Agriculture and Technology Faculty of Engineering, Department of Biotechnology and Life Science

Homepage URL (1)： http://www.ncnp.go.jp/nin/guide/r5/index.html

Research field (7)： Neuroscience - general , Pathobiochemistry , Cell biology , Molecular biology , Neurology , Orthopedics , Neuroanatomy and physiology

Research keywords (31)：統合脳・分子脳科学 , 包括脳ネットワーク , 神経科学 , 接着因子 , SOD1 , 末梢神経 , シュワン細胞 , ALS , 神経再生 , 異常タンパク仮説 , プロテオーム , 神経変性疾患 , 脳神経疾患 , RINGフィンガー , 虚血 , スプライシング , ユビキチンリガーゼ , 細胞接着 , 脱分化 , 蛋白発現調節 , ERストレス , E3 , 膜蛋白 , グルタミン合成酵素 , 髄鞘 , ユビキチン化 , ビタミンB3 , プロテアソーム , Schwann細胞 , ninjurin , 酸化ストレス

Research theme for competitive and other funds (12)：

2024 - 2027 Neuroinflammatory and degenerative pathogenesis mediated by new T cell subsets
2018 - 2024 脳科学研究の統合的推進と国際対応に関する事業開発(倫理相談窓口の設置と運用)
2018 - 2024 Study of microbiota-mediated modulation of neuroinflammastion, neurodegeneration, and neural development
2020 - 2023 神経軸索保護剤による神経傷害性疼痛治療法開発研究
2020 - 2021 Researches for Drug Development of Muscular Diseases

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Papers (107)：

Daiki Takewaki, Yuya Kiguchi, Hiroaki Masuoka, Mallahalli S. Manu, Ben J.E. Raveney, Seiko Narushima, Rina Kurokawa, Yusuke Ogata, Yukio Kimura, Noriko Sato, et al. Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis. Cell Reports. 2024. 114785-114785
Wing-Hong Jonathan Ho, Maria B Marinova, Dave R Listijono, Michael J Bertoldo, Dulama Richani, Lynn-Jee Kim, Amelia Brown, Angelique H Riepsamen, Safaa Cabot, Emily R Frost, et al. Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome. EMBO Molecular Medicine. 2024
Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki. Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation. Neuroscience Research. 2024. 205. 40-46
Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Shuji Wakatsuki, Toshiyuki Araki. Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules. Neurology International. 2024. 16. 3. 653-662
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. 2024. 12. RP89376

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MISC (42)：

大野萌馨, 若月修二, 高尾啓三, 荒木敏之. ユビキチン・プロテアソームシステム依存的タンパク質分解の破綻による神経疾患の発症機序の解明. 日本応用酵素協会誌. 2024. 58. 1-8
柳下聡介, 柴田恵, 古野暁子, 小澤裕介, 橋本翔子, 斉藤貴志, 西道隆臣, 若月修二, 荒木敏之. バンコマイシン投与による腸内細菌叢の攪乱は,脳内のAβ量を増加させる. Dementia Japan. 2023. 37. 4. 705-705
若月修二, 荒木敏之. 神経系におけるMAPKシグナルの新しい制御機構と神経発達障害との関連. Clinical Neuroscience. 2023. 41. 1. 10-11
荒木敏之. ALSにおける軸索輸送障害. Clinical Neuroscience. 2021. 39. 5. 524-525
Toshiyuki Araki. Mechanism of axonal degeneration: from molecular signaling to the development of therapeutic applications. Folia Pharmacologica Japonica. 2021. 156. 2. 66-70

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Patents (5)：

神経保護剤
神経保護剤
TDP-43プロテイノパチー治療用組成物
Ninjurin
Methods and compositions for treating neuropathies

Books (9)：

Amyotrophic lateral sclerosis
Exon publication 2021 ISBN:9780645001778
Myelin Advances in Experimental Medicine and Biology, vol 1190.
Springer 2019 ISBN:9789813296350
神経軸索変性メカニズムの研究と神経保護的疾患治療法の開発
2019
Myotonic Dystrophy~Disease Mechanism, Current Management and Therapeutic Development
Springer 2018 ISBN:9789811305078
Update on Amyotrophic Lateral Sclerosis
2016 ISBN:9789535126010

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Lectures and oral presentations (62)：

Neuroprotective therapy against neurological diseases by intervention in the NAD metabolic pathway
(47th Annual Meeting of the Molecular Biology Society of Japan 2024)
In vitro myelination model using co-culture of sensory neurons and Schwann cells both derived from human iPS cells
(EMBO workshop "Axonal Degeneration and Regeneration" 2024)
Axonal integrity evaluation system using SVM-based classifier in R
(EMBO workshop "Axonal Degeneration and Regeneration" 2024)
Hypoxia-inducible factor 1α promotes Schwann cell peripheral nerve myelination
(Society for Neuroscience meeting 2024 2024)
Axonal integrity evaluation system using SVM-based classifier in R
(8th International Axon Degeneration Conference 2024)

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Education (2)：

1990 - 1994 Osaka University Graduate School of Medicine
1983 - 1989 Osaka University Faculty of Medicine

Professional career (1)：

医学博士

Work history (2)：

2005 - 2010 国立精神・神経センター神経研究所疾病研究第5部部長
2010 - (独)国立精神・神経医療研究センター神経研究所疾病研究第5部部長

Committee career (2)：

2017/01 - 2025/12 Japan Neuroscience Society Neuroscience Research Editorial Board Member
2021/03 - 2025/03 日本神経化学会理事

Awards (1)：

2015 - 公益財団法人テルモ科学技術振興財団第3回テルモ財団賞

Association Membership(s) (9)：

THE JAPANESE BIOCHEMICAL SOCIETY , 北米神経科学学会(Society for Neuroscience) , 日本ミトコンドリア学会 , 日本分子生物学会 , 日本神経化学会 , 日本神経科学学会 , 日本ミエリン研究会 , 腸内細菌学会 , 日本再生医療学会

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