Machida Takeshi

マチダタケシ | Machida Takeshi

Affiliation and department：
Job title： Associate Professor

Research field (5)： Plants: molecular biology and physiology , Food sciences , Molecular biology , Allergies and connective tissue disease , Immunology

Research theme for competitive and other funds (11)：

2021 - 2024 Identification of the protease that activates the complement protease MASP-3 in the circulation
2018 - 2021 The role for splenic marginal zone-B cells in autoantibody production in systemic lupus erythematosus
2017 - 2018 SLEモデルマウスの自己抗体産生および腎炎病態における脾臓辺縁帯B細胞の役割
2016 - 2017 SLEモデルマウスの脾臓辺縁帯B細胞が自己抗体産生に果たす役割
2015 - 2016 SLEの自己抗体産生には辺縁帯B細胞に対するIFN-γ刺激の増強が重要である

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Papers (37)：

Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, et al. Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease. Scientific Reports. 2021. 11. 1. 8464
Yutaka Kato, Yasuharu Oguchi, Tomoko Omori, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, et al. Complement activation products and cytokines in pachychoroid neovasculopathy and neovascular age-related macular degeneration. Investigative Ophthalmology & Visual Science. 2020. 61. 39
Yasuharu Oguchi, Tetsuju Sekiryu, Tomoko Omori, Yutaka Kato, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine. Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities. Experimental Eye Research. 2020. 195. 108025
Mika Takasumi, Tomoko Omori, Takeshi Machida, Yumi Ishida, Manabu Hayashi, Toshiyuki Suzuki, Yoshimi Homma, Yuichi Endo, Minoru Takahashi, Hiromasa Ohira, et al. A novel complement inhibitor sMAP-FH targeting both the lectin and alternative complement pathways. The FASEB Journal. 2020. 34. 6598-6612
Tomoko Omori, Yasuharu Oguchi, Takeshi Machida, Yutaka Kato, Yumi Ishida, Akira Ojima, Kanako Itagaki, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, et al. Evidence for activation of lectin and classical pathway complement components in aqueous humor of neovascular age-related macular degeneration. Ophthalmic Research. 2020. 63. 252-258

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Books (1)：

The 5th International Joint Symposium between Japan and Korea. The Recent Status and Perspective of Food System, Agricultural Environment and Biology
その他の出版機関 2008

Lectures and oral presentations (89)：

The significance of the complex formation of mannose-binding lectin-associated serine protease-3 (MASP-3) with pattern recognition molecules of the lectin complement pathway in the activation of MASP-3 and the long-term retention of proenzyme MASP-3 in the circulation
(2021)
The significance of complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway in the long-term retention of MASP-3 in the circulation
(28th International Complement Virtual Workshop 2021)
MASP-3の活性化に対するレクチン経路の認識分子の役割
(第57回日本補体学会学術集会 2021)
加齢黄斑変性の病態におけるレクチン経路の関与の可能性
(第56回日本補体学会学術集会 2019)
MASP-1 and MASP-3 play independent roles in activation of the lectin and alternative complement pathways
(27th International Complement Workshop 2018)

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Education (1)：

2006 - 2009 Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioscience and Biotechnology

Professional career (2)：

農学博士 (九州大学)
Ph.D. (Kyushu University)

Work history (4)：

2018/07/01 - 現在 Fukushima Medical University School of Medicine, School of Medicine
2016/04/01 - 2018/06/30 Fukushima Medical University School of Medicine, School of Medicine
2010/04/01 - 2016/03/31 Fukushima Medical University School of Medicine, School of Medicine
2009/04/01 - 2010/03/31 九州大学大学院学術特定研究者 (日本学術振興会特別研究員PD)

Awards (3)：

2016/08 - Novo Nordisk International Travel Award for the 16th International Congress of Immunology
2015/07/09 - BioLegend Japan株式会社 BioLegend/Tomy Digital Biology Travel Award 2015 IFN-γ-receptor-1 is required for recruitment of CD19+CD1dhi marginal zone-B cells into the splenic germinal centers in lupus-prone MRL+/+ mice
2013/06/25 - 特定非営利活動法人日本免疫学会第15回国際免疫学会議Bursary Aged IRF-4-deficient lupus-prone MRL/lpr mice show peripheral B-cell deficiency with elevated serum IFN-γ levels and increased expression of IFN-γ-receptor-1 on B cells

Association Membership(s) (1)：

その他

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