Rchr
J-GLOBAL ID：201101037230271477
Update date: Sep. 26, 2024
Mayeda Akila
マエダ アキラ | Mayeda Akila
Affiliation and department：
Other affiliations (1)：
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Fujita Health University
Oncology Innovastion Center
Visitiing Professor
Homepage URL (2)：
http://www.fujita-hu.ac.jp/~mayeda/
,
http://www.fujita-hu.ac.jp/~mayeda/index-e.html
Research field (6)：
Tumor diagnostics and therapeutics
, Systems genomics
, Genomics
, Functional biochemistry
, Molecular biochemistry
, Molecular biology
Research keywords (10)：
HMGA proteins
, Splicing silencer
, Splicing enhancer
, hnRNP proteins
, SR proteins
, Alternative splicing
, Post-transcriptional regulation
, pre-mRNA splicing
, RNA processing
, Gene expression regulation
Research theme for competitive and other funds (21)：
- 2024 - 2027 The discovery of new essential splicing factors restructure a set of human introns
- 2023 - 2025 Understanding of unknown mechanism of anti-cancer
- 2021 - 2024 Understanding the mechanism underlying splicing termination with mRNA re-splicing repressor
- 2016 - 2020 癌特異的mRNA再スプライシング現象から探る遺伝子発現系の秩序維持と大規模破綻
- 2017 - 2019 癌に関わるコーディング・エクソン内のスプライシング「エキシトロン」の全貌に迫る
- 2016 - 2018 コーディングRNAから捨てられたノンコーディングRNAが生かされる仕組み
- 2013 - 2016 ゲノム変異に依存しないプロテオーム異常をスプライシング制御破綻から探る
- 2012 - 2016 Global splicing defects induced by the oncogene product HMAG1
- 2013 - 2015 Search for the rationale of aberrant protein generation in cancer cells
- 2011 - 2013 Re-splicing of mature mRNA: toward a better understanding of the mRNA quality control
- 2011 - 2012 Search for the rationale of aberrant protein generation in cancer cells
- 2008 - 2011 Expression mechanism of huge genes in human genome: proof of ‘nested splicing hypothesis’
- 2008 - 2009 Pre-mRNA splicing mechanism of human Dystrophin gene
- 2008 - 2009 Evolutional analysis of intron-length and splicing-type using global genomic databases
- 2007 - 2007 HMGA1 proteins as novel RNA-binding factors causing aberrant splicing
- 2005 - 2007 HMGA1 as a potential aberrant splicing modulator in breast cancer related genes
- 2003 - 2004 Role of HMGA1 protein in the aberrant splicing of cancer-related genes
- 2001 - 2004 Mechanisms of Dystrophin Pre-mRNA Splicing
- 2001 - 2004 Regulation of Constitutive and Alternative Pre-mRNA Splicing of Human Genes
- 2001 - 2002 Regulation of pre-mRNA Splicing by Splicing Activator RNPS1
- 1989 - 1990 mRNA前駆体スプライシング機構の研究
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Papers (84)：
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Ken-Ichi Fujita, Tomohiro Yamazaki, Akila Mayeda, Seiji Masuda. Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export. Biochemical and Biophysical Research Communications. 2024. 703. 149682-149682
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Ken-Ichi Fujita, Misa Ito, Midori Irie, Kotaro Harada, Naoko Fujiwara, Yuya Ikeda, Hanae Yoshioka, Tomohiro Yamazaki, Masaki Kojima, Bunzo Mikami, Akila Mayeda, Seiji Masuda. Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes. Nature Communications. 2024. 15. 1
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Kazuhiro Fukumura, Luca Sperotto, Stefanie Seuß, Hyun-Seo Kang, Rei Yoshimoto, Michael Sattler, Akila Mayeda. SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns. Cell Reports. 2023. 42. 12. 113534-113534
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Hiroaki Nagamine, Masakazu Yashiro, Naoki Yoshimoto, Motohiro Izumi, Akira Sugimoto, Kenji Nakahama, Koichi Ogawa, Yoshiya Matsumoto, Kenji Sawa, Yoko Tani, Hiroyasu Kaneda, Shigeki Mitsuoka, Kazuhiro Yamada, Tetsuya Watanabe, Kazuhisa Aasai, Kazuhiro Fukumura, Akila Mayeda, Tomoya Kawaguchi. RBM17 expression Is associated with the efficacy of ICI monotherapy in NSCLC with low PD-L1 expression. Anticancer Research. 2023. 43. 10. 4663-4672
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K. Fukumura, J.P. Venables, A. Mayeda. SPF45/RBM17-dependent splicing implicated in multidrug resistance in cancer chemotherapy. Mol. Cell. Oncol. 2021. ,in press
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MISC (15)：
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福村和宏, 前田明. スプライシングと抗がん剤耐性. 細胞. 2021. 53. 900-901
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Naoyuki Kataoka, Akila Mayeda, Kinji Ohno. Editorial: RNA Diseases in Humans-From Fundamental Research to Therapeutic Applications. Frontiers in molecular biosciences. 2019. 6. 53-53
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安部 明弘, 山本 幸也, 岡本 晃直, 入山 智沙子, 徳田 倍将, 稲熊 容子, 蟹江 匡治, 冨田 章裕, 赤塚 美樹, 岡本 昌隆, et al. ETV6の再構成による異所性遺伝子発現を認めた急性骨髄性白血病の二症例(Two cases of AML with ectopic gene expression resulting from the ETV6 rearrangements). 臨床血液. 2018. 59. 9. 1642-1642
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Akila Mayeda. coding RNAルネッサンス mRNA前駆体スプライシング: 分子機構とその破綻による疾患まで。. 実験医学. 2016. 34. 19. 3108-3115
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福村和宏, 前田明. coding RNAルネッサンス mRNA前駆体スプライシングの精度を保つ未知の機構を探る。. 実験医学. 2016. 34. 19. 3116-3121
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Books (4)：
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実験医学 2016年12月号 Vol.34 No.19 coding RNAルネッサンス〜RNA暗号を読み、スプライシング機構を知り、疾患治療に迫る!
羊土社 2016 ISBN:4758101582
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ノンコーディングRNA: RNA分子の全体像を俯瞰する (DOJIN BIOSCIENCE SERIES)
化学同人 2016 ISBN:4759817255
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Alternative pre-mRNA Splicing
Wiley-VCH 2012 ISBN:3527326065
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RNAがわかる-多彩な生命現象を司るRNAの機能からRNAi,創薬への応用まで (わかる実験医学シリーズ-基本&トピックス)
羊土社 2003 ISBN:4897069971
Lectures and oral presentations (191)：
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Amazing senses in nonsense RNAs
(2021)
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短いイントロンのスプライシング必須因子SPF45がどうして抗癌多剤耐性に関わるのだろうか?
(大阪市立大学大学院医学研究科・癌分子病態制御学講座(招待セミナー) 2021)
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Subsets of short introns are spliced out by distinct general splicing factors: U2AF-dependent introns, SPF45-dependent introns, and what else?
(Academia Sinica and National Taiwan University (Invited Online Seminar) 2021)
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生命現象を支える蛋白質が正しく作られる仕組み: 多種多様かつ正確無比なスプライシングの謎を解く
(第4回法医分子病理研究会(オンライン開催) 2021)
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The exon junction complex core represses cancer-specific mature mRNA re-splicing: A potential key role in terminating splicing.
(The 26th Annual Meeting of the RNA Society (online meeting) 2021)
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Professional career (1)：
- Ph.D. (Doctor of Medical Science)
Work history (3)：
- 2024/05 - 現在 xFOREST Therapuetics Co., Ltd. Special Fellow
- 2024/04 - 現在 Fujita Health University Oncology Innovation Center Visiting Professor (Professor Emeritus)
- 2007/04 - 2024/03 Fujita Health University, Institute for Comprehensive Medical Science Division of Gene Expression Mechanism Professor
Association Membership(s) (4)：
The American Society for Microbiology
, The RNA Society
, The RNA Society of Japan
, The Molecular Biology Society of Japan
