2019 - 2022 Study on the amino acid signaling via transporters and receptors for the pharmacologic control of cellular metabolism
2020 - 2021 虚血性網膜症の器官培養系解析モデルの確立と新規治療法の提唱
2018 - 2021 Amino acid signaling in the downstream of endothelially expressed amino acid transporter LAT1 that contributes to tumor angiogenesis
2019 - 2021 がん特異的アミノ酸輸送体を標的とした新規治療薬の研究開発
2018 - 2020 Study on the effects of amino acid availability on life span and the underlying molecular mechanisms
2015 - 2018 The function of a novel membrane protein in renal proximal tubules
2015 - 2018 Regulation of cellular metabolism and functions mediated by amino acid transporters and the mechanisms of action of their inhibitors
2015 - 2018 Molecular identification of amino acid sensor and its function in mTORC1 signaling pathway
2018 - Research and development of novel cancer therapeutics based on metabolic regulation targeting an amino acid transporter
2015 - 2017 Investigation of a novel lipase-like transmembrane protein for the discovery of drugs to regulate the epidermal barrier function
2014 - 2015 Identification of a Vesicle specific D-serine transporter in the brain.
2013 - 2015 Lipid metabolism in stratum corneum essential for the maintenace of intercellular ceramides mediated by a novel transmembrane lipase
2012 - 2015 Identification and the physiological role of a cystine transporter
2012 - 2015 Identification and characterization of a membrane protein TRAP involved in Fanconi syndrome like symptoms.
2012 - 2014 Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway
2011 - 2012 Function of a novel ER-localized transmembrane lipase-like protein in epidermal barrier formation
2009 - 2012 pH regulation of organelles and its physiological role and molecular mechanism
2010 - 2011 Signaling mechanisms of a novel-type transmembrane receptor 4F2hc
2009 - 2011 Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance
2005 - 2009 Organic solute transportsomes: their molecular assembly and functional significance
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Papers (43)：
Yumiao Liu, Ryuichi Ohgaki, Hiroki Okanishi, Minhui Xu, Yoshikatsu Kanai. Amino acid transporter LAT1 is expressed on cancer cell-derived exosomes with potential as a diagnostic and prognostic biomarker. Scientific Reports. 2024. 14. 28458
Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai. LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia. Scientific Reports. 2024. 14. 19635
Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai. Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells. Journal of Pharmacological Sciences. 2024. 155. 1. 14-20
Xingming Liu, Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Yoshikatsu Kanai. Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells. Journal of Pharmacological Sciences. 2024. 154. 4. 301-311
Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai. Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation. Journal of Pharmacological Sciences. 2024. 154. 3. 182-191
Ryuichi Ohgaki, Yoshikatsu Kanai. Amino acid transporter chaperons its fusogenic partner: an essential role in placenta, and its implications for physiological and pathological cell fusion. Atlas of Science (http://atlasofscience.org/). 2018
Mechanisms of the inhibition of cancer cell proliferation by LAT1 inhibitors revealed by the changes in the intracellular concentrations and function of individual amino acids
(2023)
Functional coupling with endogenous monocarboxylic acid transporter MCT1 influences on transport function of exogenously expressed organic anion transporter OAT10 in HEK293 cells: a warning on transporter assays
(2023)
Effects of the accumulation of hypoxia-inducible factors on the expression of L-type amino acid transporter LAT1 in colorectal cancer cells
(2023)
Structural basis for inhibition of human excitatory amino acid transporter EAAT2 by WAY-213613
(Strufcture, Function, and Dynamics International Conference (SFD Conference 2023))
2004 - 2007 Osaka University Graduate School of Science Department of Biological Science, PhD course
2002 - 2004 Osaka University Graduate School, Division of Natural Science Department of Biological Science, MS course
1998 - 2002 Osaka University Faculty of Science Department of Biological Science
Professional career (1)：
博士(理学) (大阪大学)
Work history (7)：
2021/03 - 現在 大阪大学大学院 医学系研究科 准教授
2020/09 - 現在 大阪大学先導的学際研究機構 生命医科学融合フロンティア研究部門(兼任)
2016/04 - 2021/02 大阪大学大学院 医学系研究科 学部内講師
2009/04 - 2021/02 大阪大学大学院 医学系研究科 助教
2009/03 - 2009/03 Osaka University Graduate School of Medicine Postdoctral fellow
2008/02 - 2009/02 Groningen University University Medical Center Groningen Visiting research felllow
2007/11 - 2009/02 Osaka University Graduate School of Science Postdoctral fellow
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Committee career (2)：
2024/03 - 現在 Discover Oncology, Editorial Borad Member
2016/04 - 現在 公益社団法人 日本薬理学会 学術評議員
Awards (4)：
2022/12 - 公益財団法人 日本膵臓病研究財団 令和4年度 膵臓病研究奨励賞
2012/09 - 第3回 分子腎臓フォーラム 優秀賞
2006/09 - Biological Science/Institute for Protein Research, Graduate School of Science, Osaka University The 21st COE Program Research Assistant Progress Report Best Poster Award
2002/03 - 大阪大学 楠本賞
Association Membership(s) (6)：
日本癌学会
, JAPANESE SOCIETY FOR AMINO ACID SCIENCES
, The Japanese Pharmacological Society
, The Japanese Society for Investigative Dermatology
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, The Japanese Biochemical Society
