Rchr
J-GLOBAL ID：201101045822602096
Update date: Apr. 03, 2024
Takizawa Hitoshi
Takizawa Hitoshi
Affiliation and department：
Job title：
Vice Director and Professor
Homepage URL (1)：
http://takizawalab.space/
Research field (2)：
Hematology and oncology
, Immunology
Research keywords (10)：
Toll-like receptor
, Innate Immunity
, Bone marrow transplantation
, humanized mice
, self-renewal
, cell division
, Cancer stem cell
, Aging
, Inflammation
, Hematopoietic stem cells
Research theme for competitive and other funds (18)：
- 2022 - 2025 Modulation of immune memory in blood stem cell toward effective host defense
- 2022 - 2024 Proteostasis crisis in erythropoiesis mediated by abnormal tRNA modification
- 2022 - 2024 Formation and maintenance of innate immune memory in hematopoietic stem cells
- 2021 - 2024 Modulation of immune memory in blood stem cell toward effective host defense
- 2021 - 2024 Inflammation-mediated hematopoietic regulation and its alternation
- 2021 - 2024 Formation of perinatal hematopoiesis in bone marrow
- 2022 - 2023 Priming Aged Hematopoietic Stem Cells by Imprinting Immune Competence
- 2020 - 2023 Improving haematopoietic reconstitution in blood stem cell transplantation procedures through the regulation of stem cells and their niches
- 2020 - 2023 Investigating the mechanisms of B cell lymphomagenesis driven by MYD88 and CD79B mutations
- 2018 - 2021 Role of inflammation in initiation and progression of clonal hematopoiesis
- 2018 - 2021 Understanding of hematopoietic stem cell trafficking across developmental hematopoietic organs
- 2018 - 2020 Inflammation induced emergence and evolution of clonal hematopoiesis
- 2017 - 2019 Mechanism of stem cell aging induced by inflammatory stress
- 2017 - 2018 Understanding of leukemic niche signal to establish niche-targeting thearpy
- 2015 - 2018 Understanding of normal and malignant niche using a novel bone marrow humanized mice
- 2016 - 2017 Generation of funtional artificial human bone marrow niche by regulating mesenchymal stromal cell division
- 2015 - 2017 Stem cell aging induced by inflammatory stress
- 2013 - 2017 Induction of self-renewal in single hematopoietic stem cells
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Papers (66)：
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Kotaro Miyako, Naoto Kajitani, Yusaku Koga, Hitoshi Takizawa, Shuken Boku, Minoru Takebayashi. Identification of the antidepressant effect of electroconvulsive stimulation-related genes in hippocampal astrocyte. Journal of Psychiatric Research. 2024. 170. 318-327
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Yusaku Koga, Naoto Kajitani, Kotaro Miyako, Hitoshi Takizawa, Shuken Boku, Minoru Takebayashi. TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice. Journal of Psychiatric Research. 2024. 170. 375-386
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Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Yuxin Wang, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa. Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells. Cancer Science. 2023. 115. 1. 197-210
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Yuxin Wang, Tatsuya Morishima, Maiko Sezaki, Ryo Sato, Gaku Nakato, Shinji Fukuda, Kouji Kobiyama, Ken J Ishii, Yuhua Li, Hitoshi Takizawa. Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals. EMBO reports. 2023
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Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, et al. GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis. Blood Advances. 2023
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MISC (7)：
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瀬崎 真衣子, 波江野 洋, 横溝 智雅, 小松 則夫, Nombela-Arrieta Cesar, 滝澤 仁. 成人造血形成における造血幹細胞の臓器間遊走(Cross-organ HSC trafficking during definitive hematopoiesis formation). 臨床血液. 2018. 59. 9. 1577-1577
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TAKIZAWA Hitoshi, TAKIZAWA Hitoshi, FRISCH Kristin, SAITO Yasuyuki, KOVTONYUK, Larisa V, MANZ Markus G. Direct sensing of lipopolysaccharide by TLR4-TRIF-ROS-p38 Pathways Limits Hematopoietic Stem Cell Fitness. 日本免疫学会総会・学術集会記録. 2015. 44. Proceedings. 147
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Anthony Rongvaux, Tim Willinger, Hitoshi Takizawa, Chozhavendan Rathinam, Elizabeth Eynon, Sean Stevens, Markus Manz, Richard Flavell. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. JOURNAL OF IMMUNOLOGY. 2011. 186
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Tim Willinger, Anthony Rongvaux, Hitoshi Takizawa, George Yancopoulos, David Valenzuela, Andrew Murphy, Wojtek Auerbach, Elizabeth Eynon, Sean Stevens, Markus Manz, et al. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. JOURNAL OF IMMUNOLOGY. 2011. 186
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Hitoshi Takizawa, Chandra S. Boddupalli, Roland R. Regoes, Sebastian Bonhoeffer, Markus G. Manz. Hematopoietic Stem Cell Cycling Dynamics In Steady State and Upon Hematopoietic Challenge. BLOOD. 2010. 116. 21. 253-253
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Books (9)：
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「炎症とクローン性造血」クローン性造血に関する知見と課題
臨床検査 2022
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マスサイトメトリーを用いたヒストン修飾・細胞内シグナル伝達の解析
羊土社 2021
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Innate immune signal-mediated hematopoietic regulation and alteration
2021
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”細菌感染はTLR4-TRIF自然免疫シグナルを介して造血幹細胞にストレスを与え、自己複製能を障害する”
実験医学 カレントトピック・羊土社 2017
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CFSEを用いた細胞分裂頻度の高感度解析
実験医学別冊 再版・羊土社 2016
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Lectures and oral presentations (27)：
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Mitochondrial Translation Drives Erythroid Differentiation via Iron Homeostasis
(Gordon Research Conferences frontiers of science, Salve Regina University, Newport, USA 2023)
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Erythroblast differentiation driven by mitochondrial translation
(Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium Feb 22-24 2023, Hawaii, USA 2023)
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Inflammatory signals in malignant stem cells
(The 6th International Workshop on Humanized Mice, Kyoto, Japan 2022)
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Innate Immune Signal-Regulated Hematopoiesis
(The 61st American Society of Hematology Annual Meeting, Orland, USA 2019)
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Inflammation-modulated early hematopoiesis
(The 81st Annual Meeting of Japanese Society of Hematology, Tokyo, Japan 2019)
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Professional career (1)：
- Ph.D. (The University of Tokyo)
Work history (9)：
- 2023/04 - 現在 Kumamoto University International Research Center for Medical Sciences Director and Professor
- 2017/01 - 2023/03 Kumamoto University International Research Center for Medical Sciences Vice Director and Professor
- 2015/01 - 2016/12 Kumamoto University International Research Center for Medical Sciences Associate Professor
- 2012/02 - 2014/12 University Hospital Zurich Division of Hematology Assistant Professor
- 2009/09 - 2012/01 University Hospital Zurich Division of Hematology Postdoctral Research Fellow
- 2009/04 - 2011/03 Japanese Science for the Promotion of Science
- 2007/04 - 2009/08 Hematopoiesis Laboratory, Institute for Research in Biomedicine Researcher
- 2006/04 - 2008/03 Japanese Science for the Promotion of Science Research Fellowship
- 2003/04 - 2007/03 Graduate School of Medical Science, The University of Tokyo
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Awards (7)：
- 2020 - The United States National Academy of Science Catalysis Award
- 2013/04 - 39th Annual meeting of the European Group For Blood and Marrow Transplantation 39th Annual meeting of the European Group For Blood and Marrow Transplantation
- 2013/03 - Basel Stem Cell Network Bruno Speck Award
- 2011/05 - International Society for Stem Cell Research Travel Award
- 2010/12 - American Society for Hematology Travel Award
- 2009/04 - 2nd International Workshop on Humanized Mice Young Investigator Award
- 2005/12 - Annual meeting of Japanese Society for Immunology Fritz Melcher’s travel award
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Association Membership(s) (6)：
The Japanese Society for Regenerative Medicine
, International Society for Experimental Hematology (ISEH)
, American Society of Hematology (ASH)
, The Molecular Biology Society of Japan (MBSJ)
, Japanese Society for Hematology (JSH)
, Japanese Society for Immunology(JSI)
