Kensuke Ikenaka

イケナカケンスケ | Kensuke Ikenaka

Affiliation and department：

Research field (1)： Neuroscience - general

Research keywords (5)： dynactin , axonal transport , amyotrophic lateral sclerosis , neurodegenerative disease , 包括脳ネットワーク

Research theme for competitive and other funds (6)：

2023 - 2027 Creation of a platform for the evaluation of signal toxicity, starting with the development of methods for the detection and diagnosis of brain function disruption.
2022 - 2026 αシヌクレインが引き起こす凝集構造多型と疾患多様性獲得機序の解明
2023 - 2025 Two Dimensions of Physiological and Pathological Activities of Synuclein Amyloid Fibrils
2022 - 2025 アルギニンジメチル化異常が与えるALS病態の解明と新規病態関連因子の同定
2021 - 2024 Elucidation of the pathogenesis and development of the treatment strategy of ALS/FTLD focusing on the local translation in neuronal axons

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Papers (80)：

Kensuke Ikenaka, Yuta Kajiyama, César Aguirre, Chi-Jing Choong, Seira Taniguchi, Junko Doi, Nan Wang, Takahiro Ajiki, Kotaro Ogawa, Keita Kakuda, et al. Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients. Pharmacology Research & Perspectives. 2024. 12. 1
Keita Kakuda, Kensuke Ikenaka, Akiko Kuma, Junko Doi, César Aguirre, Nan Wang, Takahiro Ajiki, Chi-Jing Choong, Yasuyoshi Kimura, Shaymaa Mohamed Mohamed Badawy, et al. Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles. Proceedings of the National Academy of Sciences. 2023. 121. 1
Yuto Hayashi, Tatsuhiko Ozono, Goichi Beck, Yuki Yonenobu, Rika Yamashita, Kensuke Ikenaka, Tatsusada Okuno, Shigeo Murayama, Hideki Mochizuki. Successful treatment of seronegative immune-mediated necrotizing myopathy developing during pregnancy: A case report and literature review. Neurology and Clinical Neuroscience. 2023
Naohito Ito, Mayumi Tsuji, Naoki Adachi, Shiro Nakamura, Avijite Kumer Sarkar, Kensuke Ikenaka, César Aguirre, Atsushi Michael Kimura, Yuji Kiuchi, Hideki Mochizuki, et al. Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane. NPJ Parkinson's disease. 2023. 9. 1. 139-139
Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura. Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 39. e2221553120

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MISC (23)：

古谷祥吾, 大薗達彦, 嶋津歩, 池中建介, 別宮豪一, 村山繁雄, 村山繁雄, 望月秀樹. COVID-19罹患後に四肢筋力低下を認めた一例. 臨床神経学(Web). 2023. 63. 6
Cesar Aguirre, 池中建介, 望月秀樹. シヌクレイノパチー線維の構造-Cryo-EM reveals polymorphisms of alpha-synuclein that imparts synucleinopaties-特集クライオ電顕が解き明かす神経変性疾患のメカニズム. 医学のあゆみ. 2022. 283. 13. 1121-1128
望月秀樹, 青木正志, 池中建介, 井上治久, 岩坪威, 宇川義一, 岡澤均, 小野賢二郎, 小野寺理, 北川一夫, et al. 脳神経疾患克服に向けた研究推進の提言2020、総論. 臨床神経学. 2021. 61. 11. 709-721
池中建介, AGUIRRE Cesar, 茶谷絵理, 後藤祐児, 望月秀樹. 超音波装置HANABIを用いたアミロイド関連疾患の超早期診断法の樹立. 日本アミロイドーシス学会学術集会プログラム・抄録集. 2021. 8th
野井健太郎, 池中建介, 望月秀樹, 後藤祐児, 荻博次. TIRFM-QCM測定によるアミロイド線維の動的解析. 日本生化学会大会(Web). 2021. 94th

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Books (1)：

Dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration.
[s.n.] 2013

Lectures and oral presentations (9)：

Asymmetric dimethylarginineas a novel prognostic marker for amyotrophic lateral sclerosis
(PACTALS 2021 2021)
Asymmetric dimethylarginine as a novel prognostic marker for amyotrophic lateral sclerosis
(PACTALS 2021 2021)
αシヌクレインの凝集構造多型に着目するパーキンソン病の病態解明
(日本神経病理学会 2021)
Alternative mitochondrial quality control mediated by extracellular release
(2021)
Characteristic features of FUS inclusions in spinal motor neurons of sporadic ALS
(日本神経病理学会 2020)

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Education (2)：

2009 - 名古屋大学大学院医学系研究科神経内科
2001 - 2007 Osaka University Faculty of Medicine Medical School

Professional career (1)：

医学 (名古屋大学)

Work history (3)：

2015/09 - 現在大阪大学大学院医学系研究科神経内科
2009/04 - Nagoya University Graduate School of Medicine
2003/07 - 2007/03 Osaka University Graduate School of Medicine

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