Rchr
J-GLOBAL ID:201101050539417057
Update date: Aug. 25, 2024
Katsuno Masahisa
カツノ マサヒサ | Katsuno Masahisa
Affiliation and department:
Other affiliations (2):
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Nagoya University Graduate School of Medicine
Department of Clinical Research Education
Professor
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iGCORE
Professor
Research field (1):
Neurology
Research keywords (5):
clinical trial
, translational research
, spinal and bulbar muscular atrrophy
, polyglutamine disease
, neurodegenerative disease
Research theme for competitive and other funds (53):
- 2024 - 2027 臨床研究のDXに即応した球脊髄性筋萎縮症レジストリの構築と病態マーカーの同定
- 2024 - 2027 孤発性ALS病態を反映した動物モデル作成とTDP-43凝集抑制療法の開発
- 2023 - 2026 Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases
- 2023 - 2026 Investigation of mechanistic links between tauopathies and TDP-43 proteinopathies
- 2023 - 2026 球脊髄性筋萎縮症における超早期バイオマーカーの開発
- 2022 - 2025 Development of neuronal aggregates-targeted therapeutics
- 2022 - 2025 Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosis
- 2022 - 2024 遠位型遺伝性運動ニューロパチー7型の病態解明と病態抑止療法の開発
- 2022 - 2024 運動ニューロン疾患の初期軸索病態の解明
- 2021 - 2024 球脊髄性筋萎縮症レジストリデータを用いた病態進行に関わる因子の同定
- 2021 - 2023 Wide-field Ca imaging and trans-omics for mouse model of Lewy body disease
- 2020 - 2023 非全身性血管炎性ニューロパチーの病態解明と新規治療法の開発
- 2020 - 2023 超早期ライフステージに着目した神経変性疾患の時空間特異性の解明
- 2020 - 2023 免疫介在性ニューロパチーの疾患活動性を反映する新規バイオマーカーの開発
- 2020 - 2023 孤発性ALSにおける凝集型TDP-43の生体内伝播メカニズムの解明
- 2019 - 2023 異常タンパク分解系を標的とした運動ニューロン疾患治療薬の開発
- 2019 - 2022 Elucidation of the progression of multiple system atrophy by head MRI
- 2019 - 2022 Understanding of defective developmental gene regulation responsible for motor neuron degeneration
- 2019 - 2022 候補遺伝子アプローチによる筋萎縮性側索硬化症病態関連遺伝子の探索
- 2018 - 2021 Long-term effect of leuprorelin acetate on the patients with spinal and bulbar muscular atrophy
- 2018 - 2021 球脊髄性筋萎縮症の適正治療に関するエビデンス構築のための臨床研究
- 2018 - 2020 Understanding of intrinsic readthrough mechanisms of nonsense mutations for its therapeutic applications
- 2018 - 2020 球脊髄性筋萎縮症に対する骨格筋トランスポーターを標的とした治療法開発
- 2017 - 2020 Elucidation of defective neural communication in motor neuron diseases
- 2017 - 2020 Therapeutic development based on factors affecting progression and prognosis of amyotrophic lateral sclerosis
- 2017 - 2020 Discovery of novel target and disease modifying therapy for ALS/FTLD using neuro-specific transcriptome analysis
- 2017 - 2020 Deciphering the mechanism of neuropathy and development of novel therapies in familial amyloid polyneuropathy
- 2017 - 2020 運動ニューロン疾患における神経・筋システム変性の分子病態解明と治療法開発
- 2017 - 2020 球脊髄性筋萎縮症の神経筋システム変性を標的とした革新的治療法開発
- 2017 - 2019 Analysis of genes affecting cognitive function in sporadic ALS
- 2016 - 2019 Elucidation of the axonal degenerative mechanism focusing on the paranodal molecules in immune-mediated neuropathy
- 2016 - 2019 Development of biomarkers of sleep disturbance in Parkinson's disease using salivary melatonin
- 2015 - 2018 Biomarker study in the early phase patients with spinal and bulbar muscular atrophy
- 2016 - 2017 Elucidation of dysregulation of exocytosis in sporadic amyotrophic lateral sclerosis
- 2016 - 2017 多系統萎縮症の正確な病期診断法の開発
- 2014 - 2017 Elucidation of pathogenesis of sporadic ALS using motor neuron specific-dynactin-1 knockout mice
- 2014 - 2017 Dissection of the pathomechanisms of motor neuron disease using antisense therapeutics
- 2014 - 2017 運動ニューロン疾患における神経・筋システム変性の分子病態解明と治療法開発
- 2015 - 2016 Development of biomarker and therapy for amyotrophic lateral sclerosis targeting cystatin C
- 2014 - 2016 A drug screening system for ALS by automated, quantitative motility analysis of C. elegans ALS model
- 2013 - 2015 統合的脳MRIネットワーク解析によるALSの運動機能-前頭葉機能間関連性の解明
- 2014 - 2015 球脊髄性筋萎縮症におけるクレアチニン代謝異常の病態解明と探索的臨床試験
- 2010 - 2015 運動ニューロン疾患におけるニューロサーキット変性の病態解明と治療法開発
- 2013 - 2014 Therapeutic strategy of neurodegenerative disease using microRNA
- 2011 - 2014 Development of therapy targeting dysregulation of cell cycle and JNK pathway in polyglutamine diseases
- 2009 - 2014 Development of Molecular Targeted Disease Modifying Therapy for Polyglutamine Diseases
- 2012 - 2014 球脊髄性筋萎縮症における活動依存性シナプス病態の解明と治療法の開発
- 2010 - 2012 Elucidation of pathogenesis and therapy development of sporadic ALS by disease model
- 2009 - 2010 Elucidation of cellular signaling defect and mechanism of cell-specific degeneration in polyglutamine diseases
- 2008 - 2010 Therapeutic strategy for polyglutamine-mediated motor neuron disease via molecular chaperone-ubiquitin proteasome system
- 2005 - 2009 Development of pathogenesis-based therapy for polyglutamine diseases
- 2007 - 2008 Development of animal model for sporadic ALS
- 2007 - 2008 Pathogenesis-based therapy development for polyglutamine diseases
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Papers (1,042):
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Yuto Takemoto, Daisuke Ito, Shota Komori, Yoshiyuki Kishimoto, Shinichiro Yamada, Atsushi Hashizume, Masahisa Katsuno, Masahiro Nakatochi. Comparing preprocessing strategies for 3D-Gene microarray data of extracellular vesicle-derived miRNAs. BMC bioinformatics. 2024. 25. 1. 221-221
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Naoki Suzuki, Madoka Mori-Yoshimura, Masahisa Katsuno, Masanori P Takahashi, Satoshi Yamashita, Yasushi Oya, Atsushi Hashizume, Shinichiro Yamada, Masayuki Nakamori, Rumiko Izumi, et al. Safety and efficacy of aceneuramic acid in GNE myopathy: open-label extension study. Journal of neurology, neurosurgery, and psychiatry. 2024
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Hiroshi Nishiwaki, Jun Ueyama, Mikako Ito, Tomonari Hamaguchi, Keiichi Takimoto, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Hiroshi Mori, Ken Kurokawa, et al. Meta-analysis of shotgun sequencing of gut microbiota in Parkinson's disease. NPJ Parkinson's disease. 2024. 10. 1. 106-106
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山田 晋一郎, 勝野 雅央. 【重篤な遺伝性疾患の着床前診断-患者ニーズと診断・治療の現状】疾患各論 成人期に発症する神経疾患. 臨床婦人科産科. 2024. 78. 2. 193-197
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森田 萌丹, 平野 聡子, 村上 あゆ香, 野田 成哉, 山田 晋一郎, 井口 洋平, 勝野 雅央. 心筋障害が先行し体幹筋優位の筋萎縮を認めた抗ミトコンドリアM2抗体陽性ミオパチーの2例. 臨床神経学. 2024. 64. 3. 202-202
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MISC (407):
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小野寺一成, 小野寺一成, 下門大祐, 石原康晴, 太田明伸, IRFANUR Rashid Muhammad, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, et al. 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の早期病態解明と治療開発. 日本再生医療学会総会(Web). 2023. 22nd
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伊藤卓治, ラシッドムハンマド イルファヌール, 小野寺一成, 小野寺一成, 岡田梨奈, 下門大祐, 下門大祐, 田中智史, 田中智史, 勝野雅央, et al. 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の神経・筋病態の解明. 日本再生医療学会総会(Web). 2023. 22nd
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岸本祥之, 橋詰淳, 山田晋一郎, 伊藤大輔, 小森祥太, 阿部友和, 戸田莉恵, 安永好宏, 勝野雅央, 勝野雅央. 脊髄小脳変性症患者に対する遠隔モニタリングを利用した在宅運動療法. 日本神経学会学術大会プログラム・抄録集. 2023. 64th
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前田 憲多郎, 辻河 高陽, 平野 聡子, 野田 成哉, 勝野 雅央. 呼吸障害の改善を得た骨格筋線維内に脂質蓄積を伴う成人発症ミオパチーの1例の治療経験. 神経治療学. 2022. 39. 6. S289-S289
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辻河高陽, 濱中耕平, 陸雄一, 陸雄一, 服部祐季, 井口洋平, 小林憲太, 池内健, 宮田卓樹, 松本直通, et al. アクチン結合蛋白フィラミンAはタウ凝集を促進し,進行性核上性麻痺の病理に関連する. 日本神経化学会大会抄録集(Web). 2022. 65th
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Professional career (1):
- Doctor of Medicine (Nagoya University)
Work history (11):
- 2021/04 - 現在 Nagoya University Graduate School of Medicine Department of Clinical Research Education Professor
- 2021/04 - 現在 iGCORE Professor
- 2015/07/01 - 現在 Nagoya University Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Professor
- 2012/12/01 - 2015/06/30 Nagoya University Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Associate professor
- 2011/04/01 - 2012/11/30 Nagoya University Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division Designated associate professor
- 2006/11/01 - 2011/03/31 Nagoya University Institute for Advanced Research Designated lecturer
- 2005/10 - 2006/10 Research Resident, Japan Foundation for Aging and Health
- 2004/04 - 2005/03 Reserch Resident, Japan Foundation for Aging and Health
- 2004/04 - 2004/09 Research Fellow, Nagoya University School of Medicine, Nagoya, Japan
- 1997/04 - 2000/03 Department of Neurology, Nagoya Daini Red Cross Hospital
- 1995/04 - 1997/05 Resident, Nagoya Daini Red Cross Hospital
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Awards (3):
- 2020/04/07 - MEXT, Japan Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
- 2014/05 - 日本神経学会 日本神経学会賞
- 2009/03/09 - 日本学術振興会 日本学術振興会賞
Association Membership(s) (10):
日本認知症学会
, 日本神経科学会
, 日本末梢神経学会
, 日本自律神経学会
, 日本健診医学会
, Society for Neuroscience
, 日本内科学会
, 日本神経学会
, 日本臨床薬理学会
, 日本神経治療学会
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