Makino Toshiaki

Affiliation and department：
Job title：教授
Homepage URL (1)： http://www.phar.nagoya-cu.ac.jp/hp/syg/

Research field (3)： Internal medicine - General , Pharmaceuticals - chemistry and drug development , Clinical pharmacy

Research keywords (10)：漢方薬 , 生薬 , 臨床生薬学 , 中医学 , 漢方医学 , Medicinal history , 医薬品情報学 , Standardization , 薬物相互作用 , トランスポーター

Research theme for competitive and other funds (15)：

2023 - 2026 バンコマイシン耐性腸球菌感染に対する補中益気湯による薬剤感受性回復治療の提案
2022 - 2025 大黄の修治による血流改善メカニズムの解明および漢方処方への応用
2021 - 2024 Development of analytical kit for causative agent to cause licorice-induced pseudoaldosteronism
2019 - 2022 Development of goshajinkigan products for the prevention of sarcopenia
2019 - 2022 Trial of combined use of Kampo medicine for pneumococcal vaccine therapy-Proposal of a new treatment aiming at enhancement of antibody titer

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Papers (253)：

Ryota Sakoda, Kan'ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe, Toshiaki Makino. 3-epi-18β-glycyrrhetinic acid or its glucuronide, the metabolites of glycyrrhizinic acid with individual differences, correlated with diagnostic maker for licorice-induced pseudoaldosteronism in humans. Drug Metabolism and Disposition. 2024
Xiaohang Zhou, Hui Sun, Junling Ren, Guangli Yan, Le Yang, Honglian Zhang, Haitao Lu, Xinghua Li, Toshiaki Makino, Fengting Yin, Jing Li, Xijun Wang. Mineral crude drugmirabilite (Mangxiao) inhibits the occurrence of colorectal cancer by regulating the Lactobacillus-bile acid-intestinal farnesoid X receptor axis based onmultiomics integration analysis. 2024. 5. e556
Madoka Niiya, Yota Shimato, Takamasa Ohno, Toshiaki Makino. Effects of Hovenia dulcis fruit and peduncle extract on alcohol metabolism. Journal of Ethnopharmacology. 2024. 321. 117541
Muneshige Tokugawa, Yasumichi Inoue, Hiromasa Aoki, Chiharu Miyajima, Kan'ichiro Ishiuchi, Kento Tsurumi, Chisane Kujirai, Daisuke Morishita, Michiyo Matsuno, Hajime Mizukami, et al. Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation, and proteasomal degradation. Journal of Biochemistry. 2024. 175. 3. 253-263
Misato Ota, Yuki Oiwa, Yasuhito Maki, Ichiro Utaka, Sachie Arima, Yoichi Matsuo, Toshiaki Makino, Shunsuke Nojiri. Safety evaluation of continuous administration of a high dose of Valeriana fauriei root extract in mice and in humans through an open-label study. Traditional & Kampo Medicine. 2023. 10. 269-277

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MISC (57)：

牧野利明, 関根麻理子, 嶋田沙織, 田中耕一郎, 地野充時, 田原英一, 鍋島茂樹. 漢方診療における漢方製剤の多剤併用(ポリファーマシー)の問題医療安全委員会報告. 日本東洋医学雑誌. 2024. 75. 2. 144-151
牧野利明, 南正明. 辛夷清肺湯の基礎・臨床研究に関する最近の動向. 漢方と最新治療. 2024. 33. 1. 39-48
牧野利明. 生薬ハンゲの修治に関する薬史学的研究. 日本医史学雑誌. 2023. 69. 3. 344-345
松岡尚則, 永塚憲治, 別府正志, 牧野利明. モグサの起原植物・植物名についての一考察. 藤門医林. 2023. 35. 40-43
笛木司, 田中耕一郎, 並木隆雄, 牧野利明. ハンゲのイガイガについての最近の知見生姜で本当にイガイガは治るのか. 漢方の臨床. 2023. 70. 6. 589-600

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Books (6)：

Textbook of Pharmacognosy
2021 ISBN:9784524403899
新訂生薬学(改訂第8版増補)
南江堂 2018 ISBN:4524403620
新訂生薬学(改訂第8版)
南江堂 2017 ISBN:4524403418
現代医療における漢方薬
南江堂 2016 ISBN:9784524403141
いまさら聞けない生薬・漢方薬
医薬経済社 2015 ISBN:4902968533

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Education (2)：

1995 - 2000 Kyoto University Graduate School of pharmaceutical Science
1991 - 1995 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (京都大学)

Work history (6)：

2014/04 - 現在 Graduate school of Pharmaceutical Sciences, Nagoya City University Professor
2007/04 - 2014/03 Graduate School of Pharmaceutical Sciences, Nagoya City University Associate professor
2005/04 - 2007/03 Graduate School of Pharmaceutical Sciences, Nagoya City University Lecturer
2004/04 - 2005/03 Hokkaido Pharmaceutical University School of Pharmacy Lecture
2003/10 - 2004/09 Natural Product Research Center, University of Mississippi Visiting scholar

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Committee career (27)：

2022/04 - 現在 Japanese Liaison of Oriental Medicine Chair of Committee 3
2021/05 - 現在 Frontiers in Pharmacology Editor
2019/07 - 現在 Molecules Editor
2019/05 - 現在 Scientific Reports Associate Editor
2018/04 - 現在 Evidence for Complementary and Alternative Medicine Editor

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Awards (13)：

2024/09 - Japanese Society of Pharmacognosy Best Paper Award 2024
2024/04 - Japanese Society of Medicinal History 2024 Encouragement Award
2023/09 - Japanese Society of Pharmacognosy Best Paper Award 2023
2021/09 - Japanese Society of Pharmacognosy Best Paper Award 2021 The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract
2020/09 - Japanese Society of Pharmacognosy Academic Contribution Award Exploration for the causal compounds of licorice-induced pseudoaldosteronism

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Association Membership(s) (11)：

Japanese Society of Pharmacology , Japanese Society of Food Chemistry , 日本薬物動態学会 , 日本医療薬学会 , 国際東洋医学会 , 日本社会薬学会 , 日本薬史学会 , 日本東洋医学会 , 和漢医薬学会 , 日本生薬学会 , 日本薬学会

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