kubota hiroshi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ipc.akita-u.ac.jp/~hkubota

Research field (1)： Cell biology

Research keywords (25)：品質管理 , EDEM , コラーゲン , 小胞体マンノシダーゼI , HSP47 , 小胞体関連分解 , ポリグルタミン病 , βシート , 神経変成疾患 , チューブリン , 蛍光相関分光法 , 蛋白質凝集 , アクチン , 凝集体 , 基質特異性 , 神経変性疾患 , HSP60ファミリー , タンパク質凝集 , 蛍光エネルギー共鳴 , CCT , RNAi , フォールディング , 分子シャペロン , 統合脳・病態脳 , 包括脳ネットワーク

Research theme for competitive and other funds (13)：

2015 - 2018 Development of a new theraphy for keloids with inhibition of HtrA1 and a new keloid organ culture system
2014 - 2015 異常タンパク質の分別輸送を介した細胞内分解機構
2011 - 2013 Regulation of cellular functions by highly evolved two chaperonins
2010 - 2011 凝集性異常タンパク質の脱凝集を介した分解機構
2008 - 2009 Dynamic functions of chaperonins in the cell

Show all

Papers (36)：

Satoko Yamawaki, Motoko Naitoh, Hiroshi Kubota, Rino Aya, Yasuhiro Katayama, Toshihiro Ishiko, Taku Tamura, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Mika Ikeda, et al. HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development. International journal of molecular sciences. 2018. 19. 5
Ishida R, Okamoto T, Motojima F, Kubota H, Takahashi H, Tanabe M, Oka T, Kitamura A, Kinjo M, Yoshida M, et al. Physicochemical Properties of the Mammalian Molecular Chaperone HSP60. International journal of molecular sciences. 2018. 19. 2
Kitamura A, Ishida Y, Kubota H, Pack CG, Homma T, Ito S, Araki K, Kinjo M, Nagata K. Detection of substrate binding of a collagen-specific molecular chaperone HSP47 in solution using fluorescence correlation spectroscopy. Biochemical and biophysical research communications. 2018. 497. 1. 279-284
Aya R, Ishiko T, Noda K, Yamawaki S, Sakamoto Y, Tomihata K, Katayama Y, Yoshikawa K, Kubota H, Nakamura T, et al. Regeneration of elastic fibers by three-dimensional culture on a collagen scaffold and the addition of latent TGF-β binding protein 4 to improve elastic matrix deposition. Biomaterials. 2015. 72. 29-37
Kitamura A, Inada N, Kubota H, Matsumoto G, Kinjo M, Morimoto RI, Nagata K. Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1. Genes to cells : devoted to molecular & cellular mechanisms. 2014. 19. 3. 209-224

ｍore...

MISC (8)：

Hiroshi Kubota, Akira Kitamura, Hideaki Itoh, Masataka Kinjo, Kazuhiro Nagata. Fluorescently labeled proteins as a tool for analyzing the dynamics of protein quality control in living cells. International Journal of the Society of Material Engineering for Resources. 2010. 17. 1. 1-4
Hiroshi Kubota, Yuji Yamazaki, Akira Kitamura, Yukako Oda, Shoshiro Hirayama, Kazuhiro Nagata. Mckusick-Kaufman syndrome gene product is a chaperonin-like molecule abundant in the centrosome and degraded upon disease-causing mutations. CELL STRUCTURE AND FUNCTION. 2005. 30. 45-45
黒田貴雄, 多田政子, 久保田広志, 木村博信, 秦野慎矢, 末盛博文, 中辻憲夫, 多田高. 未分化性維持因子 Nanog の転写制御機構. Genes & genetic systems. 2004. 79. 5
久保田広志, 永田和宏. タンパク質のフォールディング監視機構 (特集蛋白質の品質管理と神経疾患). 神経研究の進歩. 2004. 48. 1. 5-15
Kubota Hiroshi. Cytosolic Chaperonin CCT and Cell Growth. Ikagaku Shinpojumu. 2003. 32. 2. 139-146

ｍore...

Education (4)：

- 1992 Osaka University
- 1992 Osaka University Graduate School, Division of Medicine
- 1985 Shizuoka University Faculty of Science
- 1985 Shizuoka University Faculty of Science

Professional career (1)：

博士(医学)、修士(理学)

Work history (8)：

2016/04 - 現在秋田大学大学院理工学研究科生命科学専攻
2010 - 秋田大学工学資源学研究科教授
2008 - Akita University Faculty of Engineering and Resource Science
2007 - 京都大学京都大学再生医科学研究所助教
2000 - Japan Science and Technology Agency

Show all

Association Membership(s) (5)：

日本蛋白質科学会 , 日本分子生物学会 , 日本細胞生物学会 , 日本生化学会 , 臨床ストレス応答学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page