Takahashi Ryosuke

2016 - 2018 Neuronal circuitry rewiring during the progression of Parkinson's disease

2016 - 2018 Drug screening for suppression of alpha-synulcein expression

2015 - 2018 Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations

2015 - 2018 Creation of ALS treatment seed by latest comprehensive neuroscience research for Kii ALS/PDC

2014 - 2018 Elucidating pathomechanism of ALS through the abnormality in astrocytes

2016 - 2017 脳内環境:恒常性維持機構とその破綻

2014 - 2016 Analyzing the pathogenesis of neurodegenerative diseases using medaka with multigene mutations.

2014 - 2016 Search and functional analysis of secreted microRNA associated with mitochondrial quality control

2012 - 2016 Investigation of pathomechanism and novel therapeutic strategy for ALS on the basis of optineurin dysfunction

2011 - 2016 Brain Environment

2011 - 2016 Disturbance of brain environment by impairment of proteolysis leading to neurodegeneration

2011 - 2016 Establishment of high-throughput screening of toxic chemical compounds.

2011 - 2016 Brain Environment

2010 - 2016 Comprehensive Brain Science Network

2011 - 2014 Identification of small molecules that down-regulate alpha-synuclein transcription

2010 - 2012 Research on the role of Omi/HtrA2 in the abnormal mitochondria in patients with Parkinson's disease

2011 - 2011 遺伝性パーキンソン病動物モデルに基づく選択的ドパミン神経変性のメカニズムの解明

2009 - 2011 The inhibitory mechanism of unfolded protein accumulation in the endoplasmic reticulum : Studies on anti-neurodegeneration drug discovery

2009 - 2011 Biochemical and neuropathological analysis of HtrA2 knockout mouse

2009 - 2011 Drug development for ALS using astrocytes derived from patient-specific iPSCs

2008 - 2010 The analysis of participation in the ubiquitin proteasome system for understanding the mechanisms of neurodegenerative diseases.

2008 - 2010 Optimization of the host brain environment for the cell replacement therapy using ES cells

2008 - 2009 パエル受容体のドーパミンニューロンの機能維持と変性における役割の解明

2008 - 2009 Identification of the novel phosphokinase for tau/alpha-synuclein and the mechanisms for protein accumulation in neurodegenerative diseases

2007 - 2009 Development of an immunotherapy against ALS model mice and analysis of the role of microglia in the pathogenesis of ALS

2007 - 2008 The inhibitory mechanism of novel proteins induced in the endoplasmic reticulum and of drugs on neurodegenerative diseases

2006 - 2007 パーキンソン病におけるパエル受容体の病態的役割の解明

2006 - 2007 Elucidation of the fumctional network among the genes for familial Parkinson disease

2005 - 2006 Production of sporadic ALS model mice by targeting the ADAR2 gene in motor neurons

2005 - 2006 Motor neuron-selective cytotoxicity caused by ALS-linked mutant SOD1 proteins

2003 - 2006 Studies on the Regulatory Mechanism of Neuronal Death: Isolation of Novel Factors and Title of Preparation of Model of Neurodegenerative Disease.

2005 - 2005 パーキンソン病におけるパエル受容体の病態生理的役割の解明

2004 - 2004 ALSマウスモデルの神経変性におけるプロテアソームの役割に関する研究

2002 - 2004 The molecular mechanisms underlying neurodegeneration

2003 - 2003 運動ニューロン特異的遺伝子過剰発現マウスを用いたALSの実験的治療の研究

2002 - 2002 運動ニューロン特異的遺伝子過剰発現マウスを用いたALSの実験的治療の研究

2001 - 2001 運動ニューロン特異的遺伝子発現・ノックアウトシステムの確立

2000 - 2000 運動ニューロン特異的遺伝子発現・ノックアウトシステムの確立

1999 - 2000 Molecular mechanism of action of X-linked inhibitor of apoptosis protein

1999 - 2000 FUNCTIONAL ANALYSIS OF PARKIN

1999 - 1999 アポトーシス阻害タンパク(IAP)によるカスペース阻害の分子機構の解明

1997 - 1997 コリン作動性神経分化に伴う遺伝子発現機構の解明

1996 - 1996 コリン作動性神経分化に伴う遺伝子発現制御機構の解明

1995 - 1995 ヒトの毛様体神経栄養因子に関する分子遺伝学的研究

1995 - 1995 コリン作動性神経分化に伴う遺伝子発現制御機構の解明

1994 - 1994 ヒトの運動ニューロン栄養因子に関する分子遺伝学的研究

1994 - 1994 ヒトにおける毛様体神経栄養因子(CNTF)の遺伝的欠損に関する分子遺伝学的研究

1993 - 1993 運動ニューロン栄養因子に関する分子生物学的研究

1993 - 1993 神経終末におけるアセチルコリンの生合成及び放出の分子生物学的研究