YOKOO Tomotaka

ヨコオトモタカ | YOKOO Tomotaka

Affiliation and department：
Job title： Associate Professor
Research theme for competitive and other funds (12)：

2023 - 2026 消化管由来ペプチドBetageninのシグナル伝達の解明と糖尿病治療への応用
2023 - 2026 消化管ペプチドBetageninを標的とした膵島移植による糖尿病治療へ向けた検討
2022 - 2025 アルツハイマー病:アポリポ蛋白Eを標的とした革新的ペプチド療法の確立
2018 - 2021 Identification of receptor for novel intestinal secretory protein, Betagenin, and application to diabetes treatment.
2014 - 2016 Elucidation of pancreatic beta-cell proliferation and differentiation mechanism by novel intestinal secretory protein IBCAP (betagenin).

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Papers (4)：

Nagahiro Ochiai, Yutaka Nakachi, Tomotaka Yokoo, Takahiro Ichihara, Tore Eriksson, Yuki Yonemoto, Takehiko Kato, Hitoshi Ogata, Natsuko Fujimoto, Yasuhiro Kobayashi, et al. Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment. Communications biology. 2019. 2. 86-86
Hui Zhao, Takashi Matsuzaka, Yuta Nakano, Kaori Motomura, Nie Tang, Tomotaka Yokoo, Yuka Okajima, Song-iee Han, Yoshinori Takeuchi, Yuichi Aita, et al. Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding beta-Cell Mass and Increasing Insulin Secretory Capacity. DIABETES. 2017. 66. 7. 1833-1846
Yutaka Nakachi, Mioko Iseki, Tomotaka Yokoo, Yosuke Mizuno, Yasushi Okazaki. Gene Expression Profile of the Neonatal Female Mouse Brain After Administration of Testosterone Propionate. JOURNAL OF SEXUAL MEDICINE. 2015. 12. 4. 887-896
Nie Tang, Takashi Matsuzaka, Marii Suzuki, Yuta Nakano, Hui Zao, Tomotaka Yokoo, Noriko Suzuki-Kemuriyama, Motoko Kuba, Yuka Okajima, Yoshinori Takeuchi, et al. Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014. 450. 1. 318-323

Lectures and oral presentations (33)：

消化管ペプチドBetageninはヒト膵島のアポトーシスを抑制し、増殖とインスリン分泌を促進する
(第61回日本糖尿病学会年次学術集会 2018)
消化管ペプチドBetageninはヒトβ細胞のアポトーシスを抑制し、増殖とインスリン分泌を促進する
(第91回日本内分泌学会学術総会 2018)
ヒトゲノム解析とマウストランスクリプトーム解析の統合による性別違和(性同一性障害)関連遺伝子の探索
(第15回 RCGMフロンティアシンポジウム 2017)
Search for Gender Dysphoria (Gender Identity Disorder) related genes: Approach with Mouse transcriptome analysis and human exome analysis
(BMB2015 Biochemistry and Molecular Biology 2015)
性別違和(性同一性障害)関連遺伝子の探索:マウス発現解析とヒトエクソーム解析によるアプローチ
(BMB2015 2015)

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Professional career (1)：

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