Saito Yasuyuki

サイトウヤスユキ | Saito Yasuyuki

Affiliation and department：
Job title： Lecturer

Research field (2)： Immunology , Hematology and oncology

Research theme for competitive and other funds (9)：

2022 - 2025 Molecular basis for the regulation of dendritic ell and mature T cell survival
2022 - 2024 自然免疫系細胞の制御による新規がん免疫療法の研究開発
2020 - 2022 Development of a novel lymphoma PDX model using humanized mice
2016 - 2022 貪食細胞-がん細胞相互作用を制御する新たながん免疫療法の開発
2018 - 2020 Regulation of dendritic cells and lymphoid tissues by CD47-SIRPalpha signaling

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Papers (95)：

Tomás A Martins, Deniz Kaymak, Nazanin Tatari, Fiona Gerster, Sabrina Hogan, Marie-Françoise Ritz, Valerio Sabatino, Ronja Wieboldt, Ewelina M Bartoszek, Marta McDaid, et al. Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker. Nature communications. 2024. 15. 1. 9718-9718
Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Takaji Matsutani, Kazuhiko Doi, Hironori Sakai, Tomoki Sasaki, Takahiro Kusakabe, Sakuya Matsumoto, Yasuyuki Saito, et al. Analysis of B-cell receptor repertoire to evaluate immunogenicity of monovalent Omicron XBB.1.5 mRNA vaccines. EJHaem. 2024. 5. 4. 661-668
Alexandre P A Theocharides, Gregor Hutter, Yasuyuki Saito. Editorial: The therapeutic inhibition of macrophage checkpoints. Frontiers in immunology. 2024. 15. 1418281-1418281
Yasuyuki Saito, Rie Iida-Norita, Tania Afroj, Alaa Refaat, Daisuke Hazama, Satomi Komori, Shinya Ohata, Tomoko Takai, Okechi S. Oduori, Takenori Kotani, et al. Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models. Frontiers in Immunology. 2023. 14
Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, et al. Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH. The Journal of experimental medicine. 2023. 220. 11

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MISC (96)：

小谷武徳, 村田陽二, 齊藤泰之, 的崎尚. 【新しいがん免疫療法研究の展開と臨床応用】自然免疫制御を介したがん免疫療法の進展 CD47-SIRPα経路の制御によるがん免疫療法. 腫瘍内科. 2023. 31. 3. 327-333
齊藤泰之, 村田陽二, 的崎尚. CD47および関連分子を標的としたがん治療の可能性. がん分子標的治療. 2021. 19. 1. 82-88
羽間大祐, 村田陽二, 田中大介, 岡本武士, 齊藤泰之, 小谷武徳, 西村善博, 的崎尚. CD47-SIRPαシグナル系を標的としたマクロファージによるがん細胞排除を促進する新規大環状ペプチドの開発(A novel macrocyclic peptide targets the CD47-SIRPalpha axis and enhances the macrophage-mediated tumor killing). 日本癌学会総会記事. 2019. 78回. P-2169
Jajar Setiawan, Takenori Kotani, Tasuku Konno, Yasuyuki Saito, Yoji Murata, Tetsuo Noda, Takashi Matozaki. Regulation of Small Intestinal Epithelial Homeostasis by Tsc2-mTORC1 Signaling. The Kobe journal of medical sciences. 2019. 64. 6. E200-E209
SAITO Yasuyuki, KOMORI Satomi, DATU Respatika, WASHIO Ken, NISHIMURA Taichi, KOTANI Takenori, MURATA Yoji, MATOZAKI Takashi. SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells in the adult spleen. 臨床血液. 2018. 59. 9. 1687

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Lectures and oral presentations (55)：

Dendritic cells regulate peripheral T cell survival through the CD47-SIRPα signaling
(2022)
SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen
(The 2nd International Joint Symposium -UW,UO,KU- 2018)
Regulation of intestinal epithelial cell turnover by intertinal contents
(The 2nd International Joint Symposium -UW,UO,KU- 2018)
Development of a novel cancer immunotherapy targeting the interaction between tumor cells and macrophages
(ConBio2017(The 90th Annual Meeting of the Japanese Biochemical Society, The 40th Annual Meeting of the Molecular Biology Society of Japan) 2017)
SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen
(The 46th Annual Meeting of The Japanese Society for Immunology 2017)

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Education (2)：

2004 - 2010 Gunma University Graduate School of Medicine Course of Medical Sciences
1993 - 1999 Yamanashi Medical Univerisity School of Medicine

Professional career (1)：

Work history (6)：

2022/04 - 現在神戸大学大学院医学研究科生化学・分子生物学講座生化学・シグナル統合学分野(シグナル統合学) 講師
2014/09 - 2022/03 Kobe University Graduate School of Medicine Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Signaling, Associate Professor
2011/01 - 2014/08 University Hospital Zurich Division of Haematology Postdoctoral researcher
2008/04 - 2010/12 Gunma University, Institute for Molecular and Cellular Regulation, Department of Molecular Medicine Laboratory of Biosignal Sciences Assistant Professor
2002/12 - 2004/05 群馬大学医学部附属病院血液内科医員

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Committee career (2)：

Association Membership(s) (3)：

日本癌学会 , 日本免疫学会 , 日本血液学会

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