Rchr
J-GLOBAL ID：201101098166322614   Update date: Nov. 12, 2024

Fukuhara Takeshi

Fukuhara Takeshi
Affiliation and department：
Otsuka Pharmaceutical Co., Ltd. Neuroimmunology Laboratory, Immunology Unit, Osaka Research Center for Drug Discovery

About Otsuka Pharmaceutical Co., Ltd. Neuroimmunology Laboratory, Immunology Unit, Osaka Research Center for Drug Discovery


Research field  (4)： Immunology ,  Neuroscience - general ,  Neuroscience - general ,  Medical biochemistry
Research keywords  (20)： CD321 ,  Tight Junction ,  Neurovascularture ,  Parkinson's disease ,  Functional Antibody ,  inflammation ,  complement receptor ,  cancer stem cell ,  neural progenitor cell ,  neurogenesis ,  targeting antibody ,  cancer ,  immunotoxin ,  エピジェネティクス ,  neuroinflammation ,  cell fate specification ,  microglia ,  neuroimmunology ,  neural progenitor/stem cell ,  包括脳ネットワーク
Research theme for competitive and other funds  (17)：
  • 2019 - 2023 High dimensional analysis of neurovasculature to reveal molecular mechanism of aged or neurodegenerative brain
  • 2018 - 2021 Effect of N-containing DLC on cell adhesion and intimal proliferation in in-vivo test
  • 2017 - 2020 Transomics analysis of neuroimmune interaction in Parkinson's disease
  • 2016 - 2019 Development of non-invasive retina-targeted siRNA delivery system for overcoming a blood-retina barrier
  • 2016 - 2019 Secretome analysis of tumor microenvironment for developing immunotherapeutics
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Papers (39)：
  • Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-Ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, et al. Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nature medicine. 2023. 29. 6. 1448-1455
  • Hiroyuki Satofuka, Yayan Wang, Kyotaro Yamazaki, Shusei Hamamichi, Takeshi Fukuhara, Abdur Rafique, Nana Osako, Iori Kanazawa, Takeshi Endo, Naomi Miyake, et al. Characterization of human anti-EpCAM antibodies for developing an antibody-drug conjugate. Scientific Reports. 2023. 13. 1
  • 福原 武志, Yin Yi, 濱道 修生, 服部 信孝. マイクログリアを標的としたイムノリポソームアッセイの開発と抗体の性状解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3P-288
  • Shogo Moriya, Michiko Hanazono, Takeshi Fukuhara, Katsuro Iwase, Nobutaka Hattori, Masaki Takiguchi. A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons. Cellular and molecular life sciences : CMLS. 2022. 79. 5. 234-234
  • Enzhi Yin, Takeshi Fukuhara, Kazuyoshi Takeda, Yuko Kojima, Kyoko Fukuhara, Kenichi Ikejima, Hisashi Bashuda, Jiro Kitaura, Hideo Yagita, Ko Okumura, et al. Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury. Scientific reports. 2021. 11. 1. 6312-6312
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MISC (52)：
  • 北洞涼雅, 中川颯太, 笠松謙一, 福原武志, 平栗健二, 大越康晴. Development of a device with multiple diamond-like carbon to evaluate of cellular functions. LIFE講演概要集(CD-ROM). 2022. 2022
  • WANG Yayan, WANG Yayan, 里深博幸, 山崎匡太郎, 三宅直美, 福原武志, 押村光雄, XU Gao, 香月康宏, 香月康宏. Comparison of screening methods suitable for fully human antibody-drug conjugate development. 日本がん転移学会学術集会・総会プログラム抄録集. 2021. 30th
  • 江口広晃, 金杉和弥, 馬目佳信, 福原武志, ALANAZI Ali, 大越康晴, 平栗健二. Effect on cell growth by the thickness of DLC film. 応用物理学会秋季学術講演会講演予稿集(CD-ROM). 2021. 82nd
  • 福原 武志, 濱道 修生, Wu Winghui, 服部 信孝. 抗血管内皮抗体の探索とイムノリポソームの開発. 日本生化学会大会プログラム・講演要旨集. 2020. 93rd. [P-768]
  • 武内詩織, 武内詩織, 福原武志, 穎川博芸, 穎川博芸, 伊藤恭彦, 小橋丹青, 水谷奈津子, 水谷奈津子, 松岡周二. Establishment of a therapeutic antibody against NL lymphomas. 日本癌学会学術総会抄録集(Web). 2020. 79th. OJ12-1
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Patents (9)：
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Lectures and oral presentations  (50)：
  • 抗血管内皮抗体の探索とイムノリポソームの開発
    (日本生化学会大会プログラム 2020)
  • CD321 mAb (90G4) protects liver via inhibiting neutrophil infiltration in murine hepatic ischemia reperfusion model
    (The 48th Annual Meeting of the Japanese Society for Immunology 2019)
  • Screening technology and application of functional antibody for brain diseases
    (13th International Symposium o Nanomedicine (ISNM2019) 2019)
  • High dimensional FACS analysis revealed vascular aging as a change of subpopulation upon stress or inflammatory stimuli.
    (The 42nd Annual Meeting of the Japan Neuroscience Society, NEURO2019 2019)
  • Study of alpha synuclein dissemination for the development of therapeutic strategy
    (13th Conference of Movement Disorder Society Japan 2019)
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Education (4)：
  • 2006 - 2006 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
  • 1999 - 2002 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology
  • 1997 - 1999 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology
  • 1993 - 1997 Tokyo Institute of Technology School of Bioscience and Biotechnology
Work history (15)：
  • 2022/04 - 2022/11 Tokyo Denki University Visiting professor
  • 2020/10 - 2022/11 Juntendo University Department of Neurology Adjunct lecturer
  • 2020/10 - 2022/11 RIKEN Center for Brain Science, Neurodegenerative Disorders Collaborative Laboratory (Hattori Group) Scientist
  • 2018/04 - 2022/11 Tokyo Denki University Adjunct lecturer
  • 2021/11 - 2021/11 Chiba University Faculty of Pharmaceutical Sciences Adjunct lecturer
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Association Membership(s) (11)：
The Japanese vascular biology and medicine organization ,  The Society of symposium on Toxin ,  Japan Bio-Venture Development Association ,  JAPAN CYTOMETRY SOCIETY ,  The Antibody society ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE SOCIETY FOR BIOTECHNOLOGY, JAPAN ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  JAPAN RADIOISOTOPE ASSOCIATION ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  Japan Bioindustry Association
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