Rchr
J-GLOBAL ID：201101099578890117   Update date: May. 16, 2024

Oikawa Hiroyuki

オイカワ ヒロユキ | Oikawa Hiroyuki
Affiliation and department：
MOLCURE Inc.

About MOLCURE Inc.


Job title： Senior researcher
Other affiliations (1)：
Research field  (3)： Biophysics ,  Basic physical chemistry ,  Bio-, chemical, and soft-matter physics
Research keywords  (1)： Single-molecule spectroscopy
Research theme for competitive and other funds  (6)：
  • 2019 - 2022 一分子分光による相分離した液滴中タンパク質の構造揺らぎ追跡
  • 2018 - 2020 Tracking of protein conformational changes in crowded environments by using single-molecule fluorescence spectroscopy
  • 2017 - 2019 Tracking of protein folding transition path by single-molecule fluorescence measurements
  • 2013 - 2018 Investigation on the dynamics of protein folding by single molecule fluorescence spectroscopy
  • 2009 - 2011 Investigation of the folding dynamics of proteins based on the advanced method of single molecule detection
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Papers (14)：
  • Yutaka Sano, Yuji Itoh, Supawich Kamonprasertsuk, Leo Suzuki, Atsuhito Fukasawa, Hiroyuki Oikawa, Satoshi Takahashi. Simple and Efficient Detection Scheme of Two-Color Fluorescence Correlation Spectroscopy for Protein Dynamics Investigation from Nanoseconds to Milliseconds. ACS Physical Chemistry Au. 2024
  • Yutaka Sano, Yuji Itoh, Supawich Kamonprasertsuk, Leo Suzuki, Atsuhito Fukasawa, Hiroyuki Oikawa, Satoshi Takahashi. Lossless photon recording of two-color fluorescence correlation spectroscopy for protein dynamics investigations from nanoseconds to milliseconds. 2023
  • Shrutarshi Mitra, Hiroyuki Oikawa, Divya Rajendran, Toshiyuki Kowada, Shin Mizukami, Athi N. Naganathan, Satoshi Takahashi. Flexible Target Recognition of the Intrinsically Disordered DNA-Binding Domain of CytR Monitored by Single-Molecule Fluorescence Spectroscopy. The Journal of Physical Chemistry B. 2022. 126. 33. 6136-6147
  • Divya Rajendran, Shrutarshi Mitra, Hiroyuki Oikawa, Kulkarni Madhurima, Ashok Sekhar, Satoshi Takahashi, Athi N. Naganathan. Quantification of Entropic Excluded Volume Effects Driving Crowding-Induced Collapse and Folding of a Disordered Protein. The Journal of Physical Chemistry Letters. 2022. 13. 13. 3112-3120
  • Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi, et al. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nature Communications. 2021. 12. 1. 3655-3655
ｍore...
MISC (8)：
  • Satoshi Takahashi, Aya Yoshida, Hiroyuki Oikawa. Hypothesis: structural heterogeneity of the unfolded proteins originating from the coupling of the local clusters and the long-range distance distribution. Biophysical Reviews. 2018. 10. 2. 363-373
  • Satoshi Takahashi, Kiyoto Kamagata, Hiroyuki Oikawa. Where the complex things are: single molecule and ensemble spectroscopic investigations of protein folding dynamics. CURRENT OPINION IN STRUCTURAL BIOLOGY. 2016. 36. 1-9
  • Takuhiro Otosu, Kunihiko Ishii, Hiroyuki Oikawa, Munehito Arai, Satoshi Takahashi, Tahei Tahara. Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy on the Folding Mechanism of B Domain of Protein A. BIOPHYSICAL JOURNAL. 2015. 108. 2. 501A-501A
  • Hiroyuki Oikawa, Kiyoto Kamagata, Munehito Arai, Atsuhito Fukasawa, Hiroaki Yokota, Toru Ide, Satoshi Takahashi. Development of the Line Confocal System for the Single Molecule Tracking of Fast Folding Dynamics of Proteins. BIOPHYSICAL JOURNAL. 2015. 108. 2. 50A-51A
  • OIKAWA Hiroyuki, SAITO Masataka, TAKAHASHI Satoshi. Microsecond Dynamics of a Protein by Single-Molecule Fluorescence Measurements. Seibutsu Butsuri. 2014. 54. 5. 276-279
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Books (2)：
  • 相分離生物学の全貌
    東京化学同人 2020 ISBN:9784807913466
  • 揺らぎ・ダイナミクスと生体機能 : 物理化学的視点から見た生体分子
    化学同人 2013 ISBN:9784759815108
Lectures and oral presentations  (51)：
  • Conformational properties of the intrinsically-disordered RGG domain of LAF-1 detected by single-molecule fluorescence spectroscopy
    (The 58th Annual Meeting of the Biophysical Society of Japan 2020)
  • Conformational properties of the intrinsically-disordered RGG domain of LAF-1 detected by single-molecule fluorescence spectroscopy
    (Online Student Symposium of Japan Society for Molecular Science 2020)
  • Microsecond-resolved observation of F1 -ATPase conformational changes by single molecular fluorescence spectroscopy
    (The 57th Annual Meeting of the Biophysical Society of Japan 2019)
  • Dynamics of the helix-coil transition of alanine-based polypeptides detected by nanosecond region fluorescence correlation spectroscopy
    (The 57th Annual Meeting of the Biophysical Society of Japan 2019)
  • Dynamics of the helix-coil transition of alanine-based polypeptides detected by nanosecond region fluorescence correlation spectroscopy
    (The 13th Annual Meeting of Japan Society of Molecular Science 2019)
ｍore...
Education (2)：
  • 2002 - 2008 Tokyo Institute of Technology Science of Engineering Condensed Matter Physics
  • 1999 - 2002 Tokyo Institute of Technology School of Science Dept. of Physics
Professional career (1)：
  • 博士 (理学) (東京工業大学)
Work history (7)：
  • 2024/05 - 現在 Tokyo Institute of Technology Earth-Life Science Institute Research Scientist
  • 2022/04 - 現在 MOLCURE Inc.
  • 2015/04 - 2022/03 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Assistant Professor
  • 2011/04 - 2015/03 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research
  • 2010/04 - 2011/03 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research
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