Semba Shingo

Research field (1)： Pharmacology

Research keywords (5)：血管平滑筋 , ミオシンホスファターゼ , シグナル伝達 , MYPT , 一酸化窒素

Research theme for competitive and other funds (6)：

2022 - 2025 唾液エキソソームによるリキッドバイオプシーを可能とするFRETセンサーの開発
2015 - 2018 Analysis of microenvironment and exploration of new biomarker for pulmonary arterial hypertention
2015 - 2018 多機能ゲルによる関節軟骨自然再生誘導法の最適化に関わる機序の解明と制御
2013 - 2016 Explore the molecular mechanism of cellular differentiation induced by PAMPS gels.
2011 - 2014 Clarification of signal transmission mechanism in mesenchymal cells during spontaneous cartilage regeneration induced by multi-functional synthetic gel

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Papers (18)：

Jun Suzuka, Masumi Tsuda, Lei Wang, Shinji Kohsaka, Karin Kishida, Shingo Semba, Hirokazu Sugino, Sachiyo Aburatani, Martin Frauenlob, Takayuki Kurokawa, et al. Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering. 2021. 5. 8. 914-925
Shingo Semba, Nobuto Kitamura, Masumi Tsuda, Keiko Goto, Sadamu Kurono, Yoshihiro Ohmiya, Takayuki Kurokawa, Jian Ping Gong, Kazunori Yasuda, Shinya Tanaka. Synthetic PAMPS Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function. Journal of Biomedical Materials Research Part A. 2020
Daiki Hashimoto, Shingo Semba, Masumi Tsuda, Takayuki Kurokawa, Nobuto Kitamura, Kazunori Yasuda, Jian Ping Gong, Shinya Tanaka. Integrin α4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiatio. Biochemical and Biophysical Research Communications. 2020. 528. 1. 120-126
Kazuhiko Yoshida, Masumi Tsuda, Ryuji Matsumoto, Shingo Semba, Lei Wang, Hirokazu Sugino, Mishie Tanino, Tsunenori Kondo, Kazunari Tanabe, Shinya Tanaka. Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer. Cancer science. 2019. 110. 7. 2119-2132
Ryuji Kiyama, Takayuki Nonoyama, Susumu Wada, Shingo Semba, Nobuto Kitamura, Tasuku Nakajima, Takayuki Kurokawa, Kazunori Yasuda, Shinya Tanaka, Jian Ping Gong. Micro Patterning of Hydroxyapatite by Soft Lithography on Hydrogels for Selective Osteoconduction. Acta Biomaterialia. 2018. 81. 60-69

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MISC (9)：

鈴鹿淳, 津田真寿美, 王磊, 仙葉愼吾, 油谷幸代, 黒川孝幸, 近江谷克裕, 安田和則, きょう剣萍, 田中伸哉. ハイドロゲルを用いた癌幹細胞新規誘導法の開発. 生命科学系学会合同年次大会. 2017. 2017年度. [1P-0964]
和田進, 北村信人, 野々山貴行, 木山竜二, 仙葉愼吾, 小野寺純, 横田正司, 後藤佳子, 比嘉浩太郎, 黒川孝幸, et al. ハイドロキシアパタイト複合化PAMPS/PDMAAmダブルネットワークゲル人工軟骨の関節内におけるin vivo骨接着性評価. 日本整形外科学会雑誌. 2016. 90. 8. S1598-S1598
和田進, 北村信人, 野々山貴行, 木山竜二, 仙葉愼吾, 比嘉浩太郎, 黒川孝幸, Gong Jian Ping, 安田和則. バイオミネラリゼーションにより複合化したハイドロキシアパタイトコーティングPAMPS/PDMAAmダブルネットワークゲルの骨接着性の評価. 日本整形外科学会雑誌. 2015. 89. 8. S1585-S1585
MA Yanju, 仙葉慎吾, RAFIQUL Islam, Khan Md, 暮地本宙己, 渡部剛, 藤谷幹浩, 高後裕, LIU Yunpeng, 谷口隆信. 腸上皮細胞が形成する細胞間接着におけるfocal adhesion kinaseの機能. 日本生化学会大会(Web). 2012. 85th. 3P-575 (WEB ONLY)-575
Shingo Semba, George J. Dimopoulos, Kazuyo Kitazawa, Masumi Eto, Toshio Kitazawa. CPI-17. plays a critical role in the agonist-induced rapid development of MLC phosphorylation and contraction in arterial smooth muscle. BIOPHYSICAL JOURNAL. 2007. 130A-130A

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Professional career (1)：

博士(理学) (北海道大学)

Work history (1)：

2010 - 2011 Asahikawa Medical University School of Medicine

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