Matsui Takeshi

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/90528605.ja.html

Research keywords (3)： Neural regeneration , 人工多能性幹細胞 , 実験動物

Research theme for competitive and other funds (7)：

2021 - 2024 Human organoid-based research on the regulation of neural development by vascular systems
2020 - 2023 ヒト脳オルガノイドを用いた色素性乾皮症A群患者の進行性神経障害の機構解析
2019 - 2022 Pathophysiological analysis of repeat disease causing neurodegenerative disease using human brain organoids.
2019 - 2021 The research in the human brain development by the use of microglia-containing human brain organoids
2013 - 2014 成体ヒト線維芽細胞を用いて迅速かつ高効率に神経幹細胞を誘導する直接誘導法の確立

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Papers (22)：

Koichi Hasegawa, Takeshi K Matsui, Junpei Kondo, Ken-Ichiro Kuwako. N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo. Development (Cambridge, England). 2022. 149. 23
Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi. Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 32
Takeshi K Matsui, Yuichiro Tsuru, Koichi Hasegawa, Ken-Ichiro Kuwako. Vascularization of human brain organoids. Stem cells (Dayton, Ohio). 2021. 39. 8. 1017-1024
Naoki Iwasa, Takeshi K Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M Sakaguchi, Tomo Shiota, Shinko Kobashigawa, Mari Nakanishi, Masaya Matsubayashi, et al. Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation. Frontiers in cellular neuroscience. 2021. 15. 605030-605030
Masaya Matsubayashi, Yoshihiko M Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi, Arvand Asghari, Linh Bui, Shinko Kobashigawa, Mari Nakanishi, Riko Nagata, et al. 27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021. 35. 1. e21262

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MISC (9)：

江浦信之, 松井健, 森英一朗, 杉江和馬. ヒト多能性幹細胞を用いたドパミン作動性神経を有する脳幹オルガノイドの開発. パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2021. 14回. 108-108
杉江和馬, 小牧宏文, 倉重毅志, 大熊彩, 江浦信之, 塩田智, 井口直彦, 松井健, 阿部達哉, 形岡博史, et al. 過剰自己貪食を伴うX連鎖性ミオパチー(XMEA)の全国実態調査. 臨床神経学. 2020. 60. Suppl. S317-S317
稲冨慎一郎, 形岡博史, 澤田保彦, 下里直隆, 尾崎麻希, 西森裕佳子, 井口直彦, 田中聡人, 七浦仁紀, 小原啓弥, et al. パーキンソン病におけるレボドパ/カルビドパ配合経腸用液療法の効果と今後の課題. 臨床神経学. 2020. 60. Suppl. S320-S320
尾崎麻希, 形岡博史, 澤田保彦, 下里直隆, 稲冨慎一郎, 西森裕佳子, 井口直彦, 田中聡人, 江浦信之, 松井健, et al. パーキンソン病におけるレボドパ持続経腸療法(LCIG)の頸部姿勢異常への効果. 臨床神経学. 2020. 60. Suppl. S403-S403
西森裕佳子, 形岡博史, 桐山敬生, 七浦仁紀, 井口直彦, 尾崎麻希, 塩田智, 田中聡人, 江浦信之, 岩佐直毅, et al. 進行性核上性麻痺の各臨床病型における上小脳脚MRI高信号の検討. 臨床神経学. 2019. 59. Suppl. S270-S270

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Books (1)：

The establishment of induced pluripotent stem cells with multipotency. New English Journal Seminar: Molecular biology in 21st century.
講談社 2013 ISBN:9784061538924

Lectures and oral presentations (18)：

核膜複合体LINCによる軸索起始部の可塑性制御
(第100回日本生理学大会 2023)
核膜複合体LINCは軸索起始部の可塑性を制御する
(第99回日本生理学大会 2022)
神経の極性と可塑性に関連する軸索起始部における核-細胞骨格結合タンパク質Nesprin-1の解析
(第44回日本神経科学大会 2021)
Current and expected approaches to model blood brain barrier by human brain organoids
(3rd Mini-Symposium on The Blood-Brain Barrier from Basic to Clinical Research 2021)
Human cerebral organoids recapitulate brain formation and genetic developmental disorders
(Annual meeting of the Japanese society of neurology 2019)

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Work history (2)：

2007/04 - 2008/03 Hachinohe City Hospital
2005/04 - 2007/03 Iwai Hospital

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