Rchr
J-GLOBAL ID：201201005193045877
Update date: Apr. 25, 2024
ARITAKE Kosuke
アリタケ コウスケ | ARITAKE Kosuke
Affiliation and department：
Homepage URL (1)：
http://www.daiichi-cps.ac.jp/kenkyu/lab08.html
Research field (1)：
Pharmacology
Research theme for competitive and other funds (14)：
- 2020 - 2023 糖尿病における創傷治癒遅延に対するプロスタグランジンD2の役割
- 2016 - 2020 Studies on the mechanism of cannabonids on sleep modulation
- 2015 - 2018 Does prostaglandin become the insect gwowth control factor?
- 2014 - 2017 Chronic Treatment of Hematopoietic PGD Synthase Inhibitor Improves Skeletal Muscle Function and Cardiac Function in DMD
- 2013 - 2017 Role of myeloid-derived suppressor cells in tumor microenvironment
- 2013 - 2015 Crocin, a carotenoid pigment, promotes non-rapid eye movement sleep
- 2012 - 2015 Effects of cannabinoids on sleep/wake regulation
- 2012 - 2015 Characterization of prostaglandin-producing enzyme aiming for insect sterilization
- 2013 - 2014 ドーパミンD2受容体による覚醒調節分子機構
- 2010 - 2012 Development of the new treatment of ischemic brain injury by regulating prostaglandin D2 synthesis
- 2009 - 2011 Molecular basis of the regulation of adipogenesis by lipid mediators
- 2008 - 2010 Exploration of biological marker of insomnia
- 2007 - 2008 Lipocalin-type Prostaglandin D synthase; transporter and scavenger for Prostaglandin D2
- 2005 - 2006 プロスタグランジンD_2産生調節による外傷性大脳皮質損傷の拡大防止と修復促進
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Papers (3)：
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Shigeru Shimamoto, Yusuke Nakagawa, Yuji Hidaka, Takahiro Maruno, Yuji Kobayashi, Kazuki Kawahara, Takuya Yoshida, Tadayasu Ohkubo, Kosuke Aritake, Mahesh K Kaushik, et al. Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase. Biochemical and biophysical research communications. 2021. 569. 66-71
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Daisuke Irikura, Kosuke Aritake, Nanae Nagata, Toshihiko Maruyama, Shigeru Shimamoto, Yoshihiro Urade. Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. The Journal of biological chemistry. 2009. 284. 12. 7623-30
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Shigeru Shimamoto, Takuya Yoshida, Takashi Inui, Keigo Gohda, Yuji Kobayashi, Ko Fujimori, Toshiharu Tsurumura, Kosuke Aritake, Yoshihiro Urade, Tadayasu Ohkubo. NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity. The Journal of biological chemistry. 2007. 282. 43. 31373-9
MISC (9)：
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Keisuke Asada, Shigeru Shimamoto, Tomohiro Oonoki, Takahiro Maruno, Yuji Kobayashi, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka. Molecular Recognition Mechanism of Hematopoietic Prostaglandin D Synthase with its Cofactor and Substrate. BIOPHYSICAL JOURNAL. 2017. 112. 3. 494A-494A
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Shigeru Shimamoto, Yusuke Nakagawa, Takahiro Maruno, Yuji Kobayashi, Kosuke Aritake, Urade Yoshihiro, Yuji Hidaka. Lipocalin-Type Prostaglandin D Synthase Possesses Two Binding Sites for its Product. BIOPHYSICAL JOURNAL. 2017. 112. 3. 494A-495A
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Shigeru Shimamoto, Yuta Nakahata, Yusuke Nakagawa, Yutaro Fukuda, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka. Structural Analysis of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J(2). BIOPHYSICAL JOURNAL. 2016. 110. 3. 379A-379A
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Yuta Nakahata, Shigeru Shimamoto, Tadayasu Ohkubo, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka. Structural Analysis of Lipocalin-Type Prostaglandin D Synthase Complexed with Prostaglandin J(2). BIOPHYSICAL JOURNAL. 2015. 108. 2. 510A-510A
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Shigeru Shimamoto, Yutaro Fukuda, Takahiro Maruno, Yuji Kobayashi, Tadayasu Ohkubo, Kosuke Aritake, Yoshihiro Urade, Yuji Hidaka. The Interaction between L-PGDS and its Substrates or Products, as Determined by Isothermal Titration Calorimetry and NMR. BIOPHYSICAL JOURNAL. 2015. 108. 2. 513A-513A
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Work history (1)：
- University of Tsukuba International Institute for Integrative Sleep Medicine Associate Professor
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