Sato Takashi

サトウタカシ | Sato Takashi

Affiliation and department：
Job title： Specially appointed professor
Other affiliations (2)：

富士電機株式会社半導体事業本部松本工場健康管理センター所長
Yokohama City University Department of Pulmonology, School of Medicine

Homepage URL (1)： https://www.ingentaconnect.com/content/sil/impact/2019/00002019/00000003/art00022

Research field (1)： Respiratory medicine

Research keywords (3)：ナノ粒子 , 免疫調節性DNA , 免疫制御

Research theme for competitive and other funds (11)：

2022 - 2025 Development of genetically modified lactococcus lactis-based mucosal vaccines/drugs for COVID-19
2020 - 2024 経口用乳酸菌オリゴDNA微粒子の最適化と腸管上皮を起点とする免疫制御機構の解明
2019 - 2024 Innovative therapy for lung cancer: prophylaxis and therapy by intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment
2020 - 2022 Development of smart lactic acid bacteria
2017 - 2021 Study on the immune mechanism using oral nanocapsule with oligodeoxynucleotides from lactic acid bacteria

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Papers (83)：

Aito Murakami, Haruka Yamaguchi, Fu Namai, Takashi Sato, Maki Yamazaki, Hiroshi Uehara, Tadashi Fujii, Takumi Tochio, Kunihiro Shiomi, Takeshi Shimosato. Ad libitum feeding of silkworm larvae powder-containing diets specifically influences metabolism-related and short-chain fatty acid-producing gut bacteria in mice. Frontiers in cellular and infection microbiology. 2024. 14. 1383774-1383774
Aito Murakami, Koharu Toyomoto, Fu Namai, Takashi Sato, Tadashi Fujii, Takumi Tochio, Takeshi Shimosato. Oral administration of Brevibacterium linens from washed cheese increases the proportions of short-chain fatty acid-producing bacteria and lactobacilli in the gut microbiota of mice. Animal Science Journal. 2023. 94. 1
Taishi Onodera, Nicolas Sax, Takashi Sato, Yu Adachi, Ryutaro Kotaki, Takeshi Inoue, Ryo Shinnakasu, Takayuki Nakagawa, Shuetsu Fukushi, Tommy Terooatea, et al. CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes. Science Advances. 2023. 9. 24
Masahiro Shinoda, Shinichiro Ota, Yuto Yoshida, Takatomo Hirouchi, Kanako Shinada, Takashi Sato, Miwa Morikawa, Naoki Ishii, Masaharu Shinkai. High Fever, Wide Distribution of Viral Pneumonia, and Pleural Effusion are More Critical Findings at the First Visit in Predicting the Prognosis of COVID-19: A Single Center, retrospective, Propensity Score-Matched Case-Control Study. International Journal of General Medicine. 2023. Volume 16. 2337-2348
Suzuka Oshima, Fu Namai, Takashi Sato, Takeshi Shimosato. Development of a Single-Chain Fragment Variable that Binds to the SARS-CoV-2 Spike Protein Produced by Genetically Modified Lactic Acid Bacteria. Molecular Biotechnology. 2023

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MISC (13)：

K. Suzuki, F. Namai, N. Nomura, Y. Sato, A. Kotsugai, T. Shimosato, T. Sato. Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis. D29. TRANSLATIONAL RESEARCH IN IPF. 2023. 207. A6476
N. Nomura, F. Namai, T. Sato, T. Shimosato. Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice. C70. COPD (AND LUNG CANCER) CLINICAL AND TRANSLATIONAL STUDIES. 2023. 207. A5754
Kentaro Nakashima, Yu Hara, Takashi Sato, Masaharu Shinkai, Takeshi Kaneko. A Case of Adenocarcinoma of the Lung With EGFR T790 Mutation Presenting With Chylous Ascites. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2018. 13. 8. 1227-1228
T. Sato, K. Nakashima, Y. Shibata, H. Sasaki, M. Ikeda, A. Nagashima, H. Watanabe, K. Nagai, H. Nagakura, N. Horita, et al. Toll-Like Receptor 9, A Key To Attenuate Disease Progression In A Murine Model Of COPD. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017. 195
Y. Shibata, T. Sato, M. Ikeda, H. Sasaki, A. Nagashima, R. Ushio, K. Nakashima, H. Watanabe, K. Nagai, K. Tashiro, et al. Serum Cxcl16 As A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017. 195

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Patents (4)：

PHARMACEUTICAL COMPOSITION
Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer
Use of CpG oligodeoxynucleotides to induce epithelial cell growth
Method of treating pneumoconiosis with oligodeoxy- nucleotides

Books (7)：

Innovative therapy for lung cancer - intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment -
2024
Development of microbial therapeutics for the prevention/suppression of cancer and beyond
2024
Innovative therapy for lung cancer - intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment -
BIO Clinica 2023;38(7):638-42 2023
Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
IntechOpen 2022 ISBN:9781803567679
Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents
Science Impact Ltd 2019

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Lectures and oral presentations (5)：

Intratracheal therapy using oligodeoxynucleotides and/or genetically modified lactic acid bacteria-derived biological molecules
(The Korean Society of Toxicology/The Korean Environmental Mutagen Society 2022 KSOT/KEMS Spring International Symposium 2022)
Innovative therapy for lung cancer ~Intratracheal delivery of nanomicroparticles-incorporated immune checkpoint-blocking single-chain variable fragment~
(NIH/NCI Symposium on Innate Immunity & Modulation of the Host Immune Response in Honor of the Career of Dr. Dennis Klinman 2019)
吸入治療イノベーション~吸入薬で肺癌の制御を目指す研究開発の取り組み~
(横浜市立大学先端医科学研究センター第54回市民講座 2018)
Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect of long-term immune responses on murine lung cancer
(THE 14TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS 2017)
Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect on murine lung cancer
(THE 13TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS 2015)

Education (3)：

2002 - 2006 Yokohama City University Graduate School of Medicine Department of Internal Medicine and Clinical Immunology
1994 - 2000 Yokohama City University School of Medicine
1990 - 1994 Tokyo Instutute of Technology School of Engineering Department of Mechano-Aerospace Engineering

Professional career (2)：

博士(医学) (横浜市立大学)
Bachelor of Engineering (Tokyo Institute of Technology)

Work history (12)：

2024/04 - 現在富士電機株式会社半導体事業本部松本工場健康管理センター所長
2022/04 - 現在富士電機株式会社半導体事業本部松本工場専属産業医
2020/04 - 現在 Yokohama City University Department of Pulmonology, School of Medicine
2019/08 - 現在 Shinshu University Interdisciplinary Cluster for Cutting Edge Research
2020/04 - 2022/03 Tokyo Shinagawa Hospital Head of Medical Oncology Department/Director of Research Center

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Committee career (3)：

2017/04 - 2020/04 日本呼吸器学会国際委員会委員
2012/04 - 2015/05 米国胸部疾患学会(American Thoracic Society) プログラム委員
2008/04 - 2010/05 米国胸部疾患学会(American Thoracic Society) プログラム委員

Awards (6)：

2013/11 - National Institute of Health Fellows Award for Research Excellence (FARE) 2014
2013/04 - 米国国立衛生研究所 Appreciation Award
2009/01 - 横浜市立大学第一内科同門会賞
2008/10 - 神奈川難病財団研究奨励賞
2007/05 - The Oak Ridge Institute for Science and Education (ORISE) Research Award

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